| Sequence 1: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_034376.1 | Gene: | Fzd9 / 14371 | MGIID: | 1313278 | Length: | 592 | Species: | Mus musculus |
| Alignment Length: | 579 | Identity: | 134/579 - (23%) |
|---|---|---|---|
| Similarity: | 240/579 - (41%) | Gaps: | 98/579 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 100 CFGSKLP------YELSSLDLTDFHTEK-ELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKC-E 156
Fly 157 KINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRC------------------NETLFPTKC 203
Fly 204 TNG-----------------ARGMKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDE 251
Fly 252 HRQIHKLIGWA---GSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSG 313
Fly 314 SREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDR 375
Fly 376 IDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGY 440
Fly 441 FITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEW 503
Fly 504 -AQSFRQFIICKISSVFEEKSSCRIE--NRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKR 565
Fly 566 --YIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGR--------LSITLYNTHTDP 614 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 33/163 (20%) |
| Frizzled | 246..568 | CDD:279827 | 87/334 (26%) | ||
| Fzd9 | NP_034376.1 | CRD_FZ9 | 36..162 | CDD:143572 | 24/123 (20%) |
| Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 | 59..173 | 24/115 (21%) | |||
| 7tmF_FZD9 | 222..543 | CDD:320164 | 86/330 (26%) | ||
| TM helix 1 | 231..256 | CDD:320164 | 7/24 (29%) | ||
| TM helix 2 | 265..286 | CDD:320164 | 2/20 (10%) | ||
| TM helix 3 | 315..341 | CDD:320164 | 11/25 (44%) | ||
| TM helix 4 | 358..374 | CDD:320164 | 9/15 (60%) | ||
| TM helix 5 | 396..426 | CDD:320164 | 8/29 (28%) | ||
| TM helix 6 | 445..472 | CDD:320164 | 8/26 (31%) | ||
| TM helix 7 | 504..529 | CDD:320164 | 6/24 (25%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 533..538 | 0/4 (0%) | |||
| Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 | 555..592 | 8/45 (18%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D509772at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.820 | |||||