DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and Fzd7

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_032083.3 Gene:Fzd7 / 14369 MGIID:108570 Length:572 Species:Mus musculus


Alignment Length:525 Identity:132/525 - (25%)
Similarity:225/525 - (42%) Gaps:109/525 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   |....|...:|....:.|..
Mouse    73 HTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL---DQAIPPCRSLCERARQGCEA 133

  Fly   182 LYNTTFF--PKFLRCNETLFPT----------KCTNGARGMKFNGTGQCLSPLVPTDTSASYYP- 233
            |.|...|  |:.|||..  ||.          ..::|:.|...:.|....:|.:|.....:..| 
Mouse   134 LMNKFGFQWPERLRCEN--FPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPS 196

  Fly   234 ---------------------------GIEGCGVRCKDP------LYTDDEHRQIHKLIGWAG-- 263
                                       |...||..| :|      :|..:|.|:..:|  |.|  
Mouse   197 DGRGRLSFPFSCPRQLKVPPYLGYRFLGERDCGAPC-EPGRANGLMYFKEEERRFARL--WVGVW 258

  Fly   264 -SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACV----GWLLQFTSGSREDIVC--- 320
             .:|..|.||.|.|:.:|.:..: ||...:.:::.|:.:..|    |:||:      :..||   
Mouse   259 SVLCCASTLFTVLTYLVDMRRFS-YPERPIIFLSGCYFMVAVAHVAGFLLE------DRAVCVER 316

  Fly   321 -RKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGS 381
             ..||....::.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....
Mouse   317 FSDDGYRTVAQGTKKE--GCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGH--EAIEANSQ 377

  Fly   382 YFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGM 446
            ||||.||::|.|.|||.:|..:|||:.:.|:|:||..:.....|.:|.||...:.||..|:..|.
Mouse   378 YFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGF 442

  Fly   447 VMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSF 507
            |.||.    :||      ..:.:.|:..:::|:||.::|..|...:.:||:..|....:.|.   
Mouse   443 VSLFRIRTIMKH------DGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE--- 498

  Fly   508 RQFII--CKISSV------FEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWK 564
            |.:::  ||..:|      |...|       |...|..:..|.....||....|.|:..::::|:
Mouse   499 RTWLLQTCKSYAVPCPPGHFSPMS-------PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWR 556

  Fly   565 RYIRK 569
            |:..:
Mouse   557 RFYHR 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 28/115 (24%)
7tmF_SMO_homolog 245..568 CDD:320158 97/354 (27%)
TM helix 1 254..279 CDD:320158 9/27 (33%)
TM helix 2 289..310 CDD:320158 5/24 (21%)
TM helix 3 340..366 CDD:320158 8/25 (32%)
TM helix 4 382..398 CDD:320158 10/15 (67%)
TM helix 5 420..449 CDD:320158 9/28 (32%)
TM helix 6 471..498 CDD:320158 8/26 (31%)
TM helix 7 529..554 CDD:320158 5/24 (21%)
Fzd7NP_032083.3 CRD_FZ7 45..169 CDD:143575 25/101 (25%)
7tmF_FZD7 241..571 CDD:320374 96/350 (27%)
TM helix 1 250..275 CDD:320374 9/26 (35%)
TM helix 2 284..305 CDD:320374 2/20 (10%)
TM helix 3 335..361 CDD:320374 8/25 (32%)
TM helix 4 378..394 CDD:320374 10/15 (67%)
TM helix 5 416..445 CDD:320374 9/28 (32%)
TM helix 6 465..492 CDD:320374 8/26 (31%)
TM helix 7 521..546 CDD:320374 6/31 (19%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 550..555 0/4 (0%)
PDZ-binding 570..572
Blue background indicates that the domain is not in the aligned region.

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