DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smo and Fzd6

DIOPT Version :9

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_001155966.1 Gene:Fzd6 / 14368 MGIID:108474 Length:709 Species:Mus musculus


Alignment Length:679 Identity:157/679 - (23%)
Similarity:260/679 - (38%) Gaps:153/679 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 KCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCN---- 195
            :|...|:.|||..|.|.| |:|:    |.||..::|...:..|:.|.:|  ..:|:.|.||    
Mouse    68 ECSPNIEMFLCQAFIPTCTEQIH----VVLPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPH 128

  Fly   196 -------------ETLFPTK------------C-----TNGARGMKFNGTGQCLSPLVPTDTSAS 230
                         |...|.|            |     |:|.:|.:|.|..||..|         
Mouse   129 CDDTVPVTSHPHTELSGPQKKSDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPP--------- 184

  Fly   231 YYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYI 295
                       |.:..:..||.......||.....||.:.||...||.||.:.. :||...:.|.
Mouse   185 -----------CPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYY 237

  Fly   296 NLCFLIACVGWLLQFTSGSREDIVCRK-DGTLRHSEPT--AGENLSCIVIFVLVYYFLTAGMVWF 357
            ::|:.|..:.:.:.|..|:  ...|.| |..|...:..  ..:|.:|.|:|:.:|:|..||.||:
Mouse   238 SVCYSIVSLMYFVGFLLGN--STACNKADEKLELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWW 300

  Fly   358 VFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVG 416
            |.||..|      .|..     :.|::|..:||.|||..|..||:..:|.::|:|::|.|:||||
Mouse   301 VILTITWFLAAGRKWSC-----EAIEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVG 360

  Fly   417 YINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSAS-NKIHLIIMRMGVCAL 480
            ..:.......:|.|||..:.:|...:..|::   .|.|....|:....: .|:...::|:||.:.
Mouse   361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGII---SLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422

  Fly   481 LTLVFILVAIACHVTEFRHADEWAQSF-----RQFIICKISSVFEEKSSCRIENRPSVGVLQLHL 540
            |.||.::..:.|:|.|..:...|..::     .|:   :|...::.....    ||.:.:..:..
Mouse   423 LYLVPLVTLLGCYVYELVNRITWEMTWFSDHCHQY---RIPCPYQANPKA----RPELALFMIKY 480

  Fly   541 LCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSI 605
            |.....||....|..:..:...|..:.::...::.:.|    ..:|:.::.    :|..|....:
Mouse   481 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISE----SRRVLQESC----EFFLKHNSKV 537

  Fly   606 TLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPR------ 664
            .....|..|.                         |..:|......|.:||.:::||..      
Mouse   538 KHKKKHGAPG-------------------------PHRLKVISKSMGTSTGATTNHGTSAMAIAD 577

  Fly   665 KNSLDSEISVSVRHVSVESRRNSVDSQVSVK--IAEMKTKVASRSR--GKHGGSSS------NRR 719
            .:.|..|.|..| |.|.|:         |||  .|:.....:::.|  |:..|.||      |.|
Mouse   578 HDYLGQETSTEV-HTSPEA---------SVKEGRADRANTPSAKDRDCGESAGPSSKLSGNRNGR 632

  Fly   720 TQRRRDYIAAATGKSSRRRESSTSVESQV 748
            ..|.......:.|......|...|.:|.|
Mouse   633 ESRAGGLKERSNGSEGAPSEGRVSPKSSV 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 32/119 (27%)
Frizzled 246..568 CDD:279827 86/336 (26%)
Fzd6NP_001155966.1 CRD_FZ6 20..146 CDD:143559 22/81 (27%)
7tmF_FZD6 188..508 CDD:320160 86/337 (26%)
TM helix 1 198..222 CDD:320160 8/23 (35%)
TM helix 2 231..252 CDD:320160 3/20 (15%)
TM helix 3 283..305 CDD:320160 10/21 (48%)
TM helix 4 326..342 CDD:320160 8/15 (53%)
TM helix 5 364..387 CDD:320160 5/22 (23%)
TM helix 6 418..440 CDD:320160 8/21 (38%)
TM helix 7 469..494 CDD:320160 5/28 (18%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 498..503 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 583..709 23/89 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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