Protein Alignment smo and Fzd6

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_032082.3
• Gene: Fzd6 / 14368
• MGIID: 108474
• Length: 709
• Species: Mus musculus
• Alignment Length: 679
• Identity: 157/679 - (23%)
• Similarity: 260/679 - (38%)
• Gaps: 153/679 - (22%)

  Fly   138 KCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCN---- 195
            :|...|:.|||..|.|.| |:|:    |.||..::|...:..|:.|.:|  ..:|:.|.||
Mouse    68 ECSPNIEMFLCQAFIPTCTEQIH----VVLPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPH 128

  Fly   196 -------------ETLFPTK------------C-----TNGARGMKFNGTGQCLSPLVPTDTSAS 230
                         |...|.|            |     |:|.:|.:|.|..||..|
Mouse   129 CDDTVPVTSHPHTELSGPQKKSDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPP--------- 184

  Fly   231 YYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYI 295
                       |.:..:..||.......||.....||.:.||...||.||.:.. :||...:.|.
Mouse   185 -----------CPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYY 237

  Fly   296 NLCFLIACVGWLLQFTSGSREDIVCRK-DGTLRHSEPT--AGENLSCIVIFVLVYYFLTAGMVWF 357
            ::|:.|..:.:.:.|..|:  ...|.| |..|...:..  ..:|.:|.|:|:.:|:|..||.||:
Mouse   238 SVCYSIVSLMYFVGFLLGN--STACNKADEKLELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWW 300

  Fly   358 VFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVG 416
            |.||..|      .|..     :.|::|..:||.|||..|..||:..:|.::|:|::|.|:||||
Mouse   301 VILTITWFLAAGRKWSC-----EAIEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVG 360

  Fly   417 YINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSAS-NKIHLIIMRMGVCAL 480
            ..:.......:|.|||..:.:|...:..|::   .|.|....|:....: .|:...::|:||.:.
Mouse   361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGII---SLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422

  Fly   481 LTLVFILVAIACHVTEFRHADEWAQSF-----RQFIICKISSVFEEKSSCRIENRPSVGVLQLHL 540
            |.||.::..:.|:|.|..:...|..::     .|:   :|...::.....    ||.:.:..:..
Mouse   423 LYLVPLVTLLGCYVYELVNRITWEMTWFSDHCHQY---RIPCPYQANPKA----RPELALFMIKY 480

  Fly   541 LCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSI 605
            |.....||....|..:..:...|..:.::...::.:.|    ..:|:.::.    :|..|....:
Mouse   481 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISE----SRRVLQESC----EFFLKHNSKV 537

  Fly   606 TLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPR------ 664
            .....|..|.                         |..:|......|.:||.:::||..
Mouse   538 KHKKKHGAPG-------------------------PHRLKVISKSMGTSTGATTNHGTSAMAIAD 577

  Fly   665 KNSLDSEISVSVRHVSVESRRNSVDSQVSVK--IAEMKTKVASRSR--GKHGGSSS------NRR 719
            .:.|..|.|..| |.|.|:         |||  .|:.....:::.|  |:..|.||      |.|
Mouse   578 HDYLGQETSTEV-HTSPEA---------SVKEGRADRANTPSAKDRDCGESAGPSSKLSGNRNGR 632

  Fly   720 TQRRRDYIAAATGKSSRRRESSTSVESQV 748
            ..|.......:.|......|...|.:|.|
Mouse   633 ESRAGGLKERSNGSEGAPSEGRVSPKSSV 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	32/119 (27%)
		7tmF_SMO_homolog	245..568	CDD:320158	86/337 (26%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	12/31 (39%)
		TM helix 4	382..398	CDD:320158	8/15 (53%)
		TM helix 5	420..449	CDD:320158	6/28 (21%)
		TM helix 6	471..498	CDD:320158	9/26 (35%)
		TM helix 7	529..554	CDD:320158	5/24 (21%)
Fzd6	NP_032082.3	CRD_FZ6	20..146	CDD:143559	22/81 (27%)
		7tmF_FZD6	188..508	CDD:320160	86/337 (26%)
		TM helix 1	197..222	CDD:320160	8/24 (33%)
		TM helix 2	231..252	CDD:320160	3/20 (15%)
		TM helix 3	283..309	CDD:320160	12/25 (48%)
		TM helix 4	326..342	CDD:320160	8/15 (53%)
		TM helix 5	364..393	CDD:320160	6/31 (19%)
		TM helix 6	413..440	CDD:320160	9/26 (35%)
		TM helix 7	469..494	CDD:320160	5/28 (18%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503		0/4 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..709		23/89 (26%)