DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and Fzd5

DIOPT Version :9

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_001036124.1 Gene:Fzd5 / 14367 MGIID:108571 Length:585 Species:Mus musculus


Alignment Length:545 Identity:143/545 - (26%)
Similarity:230/545 - (42%) Gaps:120/545 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 CFGSKLPYELSSLDLTDFH-TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDM 163
            |.|  :.|.|:.:.....| |:.|...:::.::.|..: .|...::.|||:::.|.|        
Mouse    41 CRG--IGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEI-HCSPDLRFFLCSMYTPIC-------- 94

  Fly   164 VYLPSYEMCRITMEPCRIL-----------------------------------------YN--- 184
              ||.|..   .:.|||.:                                         ||   
Mouse    95 --LPDYHK---PLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSE 154

  Fly   185 -TTFFPKFLRCNETLFPTKCT-NGARGMKFNGTGQCLS----------PLVP-TDTSASYYPGIE 236
             ||..||       .||.|.| .|..|...:| |:|.|          |.|| ...|...|..:.
Mouse   155 ATTASPK-------SFPAKPTLPGPPGAPSSG-GECPSGGPSVCTCREPFVPILKESHPLYNKVR 211

  Fly   237 -----GCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYIN 296
                 .|.|.|..|.::.||.......||....:|.:|....|:||.||.:.. :||...:.:::
Mouse   212 TGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERF-RYPERPIIFLS 275

  Fly   297 LCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLT 361
            .|:|...:|:|::...| ...:.|.::.:..|.| |.|..| |.|:|:|||:|..|..:|:|.|:
Mouse   276 ACYLCVSLGFLVRLVVG-HASVACSREHSHIHYE-TTGPAL-CTVVFLLVYFFGMASSIWWVILS 337

  Fly   362 YAWHWRA-MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAG 425
            ..|...| |....:.|.....||||.||.:|.|.:||.:|.|.|||:.:.|||:||..|.:...|
Mouse   338 LTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRG 402

  Fly   426 LLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAI 490
            .:||||...:|:|..|:..|.|.||.::....  :..:.::|:..:::|:|:..||..|...:.:
Mouse   403 FVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIK--QGGTKTDKLEKLMIRIGIFTLLYTVPASIVV 465

  Fly   491 ACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIEN--------RPSVGVLQL-HLLCLFSS 546
            ||::.|..:.:.|                |...:|....        :|...||.| :.:||. .
Mouse   466 ACYLYEQHYRESW----------------EAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLV-V 513

  Fly   547 GIVMSTWCWTPSSIETWKRYIRKKC 571
            ||....|.|:..::|:|:|:..:.|
Mouse   514 GITSGVWIWSGKTLESWRRFTSRCC 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 36/177 (20%)
Frizzled 246..568 CDD:279827 97/331 (29%)
Fzd5NP_001036124.1 CRD_FZ5 29..156 CDD:143569 22/130 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..182 12/33 (36%)
7tm_GPCRs 225..535 CDD:333717 98/332 (30%)
TM helix 1 235..259 CDD:320095 7/23 (30%)
TM helix 2 268..289 CDD:320095 4/20 (20%)
TM helix 3 316..338 CDD:320095 10/21 (48%)
TM helix 4 359..375 CDD:320095 9/15 (60%)
TM helix 5 397..420 CDD:320095 8/22 (36%)
TM helix 6 448..473 CDD:320095 8/24 (33%)
TM helix 7 496..521 CDD:320095 8/25 (32%)
PDZ-binding. /evidence=ECO:0000250 582..584
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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