DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and Fzd5

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_073558.2 Gene:Fzd5 / 14367 MGIID:108571 Length:585 Species:Mus musculus


Alignment Length:545 Identity:143/545 - (26%)
Similarity:230/545 - (42%) Gaps:120/545 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 CFGSKLPYELSSLDLTDFH-TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDM 163
            |.|  :.|.|:.:.....| |:.|...:::.::.|..: .|...::.|||:::.|.|        
Mouse    41 CRG--IGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEI-HCSPDLRFFLCSMYTPIC-------- 94

  Fly   164 VYLPSYEMCRITMEPCRIL-----------------------------------------YN--- 184
              ||.|..   .:.|||.:                                         ||   
Mouse    95 --LPDYHK---PLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSE 154

  Fly   185 -TTFFPKFLRCNETLFPTKCT-NGARGMKFNGTGQCLS----------PLVP-TDTSASYYPGIE 236
             ||..||       .||.|.| .|..|...:| |:|.|          |.|| ...|...|..:.
Mouse   155 ATTASPK-------SFPAKPTLPGPPGAPSSG-GECPSGGPSVCTCREPFVPILKESHPLYNKVR 211

  Fly   237 -----GCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYIN 296
                 .|.|.|..|.::.||.......||....:|.:|....|:||.||.:.. :||...:.:::
Mouse   212 TGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERF-RYPERPIIFLS 275

  Fly   297 LCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLT 361
            .|:|...:|:|::...| ...:.|.::.:..|.| |.|..| |.|:|:|||:|..|..:|:|.|:
Mouse   276 ACYLCVSLGFLVRLVVG-HASVACSREHSHIHYE-TTGPAL-CTVVFLLVYFFGMASSIWWVILS 337

  Fly   362 YAWHWRA-MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAG 425
            ..|...| |....:.|.....||||.||.:|.|.:||.:|.|.|||:.:.|||:||..|.:...|
Mouse   338 LTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRG 402

  Fly   426 LLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAI 490
            .:||||...:|:|..|:..|.|.||.::....  :..:.::|:..:::|:|:..||..|...:.:
Mouse   403 FVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIK--QGGTKTDKLEKLMIRIGIFTLLYTVPASIVV 465

  Fly   491 ACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIEN--------RPSVGVLQL-HLLCLFSS 546
            ||::.|..:.:.|                |...:|....        :|...||.| :.:||. .
Mouse   466 ACYLYEQHYRESW----------------EAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLV-V 513

  Fly   547 GIVMSTWCWTPSSIETWKRYIRKKC 571
            ||....|.|:..::|:|:|:..:.|
Mouse   514 GITSGVWIWSGKTLESWRRFTSRCC 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 36/177 (20%)
7tmF_SMO_homolog 245..568 CDD:320158 98/332 (30%)
TM helix 1 254..279 CDD:320158 7/24 (29%)
TM helix 2 289..310 CDD:320158 4/20 (20%)
TM helix 3 340..366 CDD:320158 11/25 (44%)
TM helix 4 382..398 CDD:320158 9/15 (60%)
TM helix 5 420..449 CDD:320158 10/28 (36%)
TM helix 6 471..498 CDD:320158 8/26 (31%)
TM helix 7 529..554 CDD:320158 8/33 (24%)
Fzd5NP_073558.2 CRD_FZ5 29..156 CDD:143569 22/130 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..182 12/33 (36%)
7tm_GPCRs 225..535 CDD:475119 98/332 (30%)
TM helix 1 235..259 CDD:320377 7/23 (30%)
TM helix 2 268..289 CDD:320377 4/20 (20%)
TM helix 3 316..338 CDD:320377 10/21 (48%)
TM helix 4 359..375 CDD:320377 9/15 (60%)
TM helix 5 397..420 CDD:320377 8/22 (36%)
TM helix 6 451..473 CDD:320377 7/21 (33%)
TM helix 7 496..521 CDD:320377 8/25 (32%)
PDZ-binding. /evidence=ECO:0000250 582..584
Blue background indicates that the domain is not in the aligned region.

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