Protein Alignment smo and Fzd4

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_032081.3
• Gene: Fzd4 / 14366
• MGIID: 108520
• Length: 537
• Species: Mus musculus
• Alignment Length: 563
• Identity: 155/563 - (27%)
• Similarity: 242/563 - (42%)
• Gaps: 114/563 - (20%)

  Fly    74 FDGLDSRHIQCVRRARCYPTS-NATNTCFGSKLP----YEL---SSLDLTDFHTEKELNDKLNDY 130
            |...:.|....:|.|.|.... |.|      |:|    :||   :.|.||.|       ..|..|
Mouse    37 FGDEEERRCDPIRIAMCQNLGYNVT------KMPNLVGHELQTDAELQLTTF-------TPLIQY 88

  Fly   131 YALKHVPKCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCR-ILYNTTF-FPKFL 192
                   .|.:.:|.|||:|:.|.| ||||   :...|...||......|. :|....| :|..|
Mouse    89 -------GCSSQLQFFLCSVYVPMCTEKIN---IPIGPCGGMCLSVKRRCEPVLREFGFAWPDTL 143

  Fly   193 RCNETLFPTKCTNGARGMKFNGTGQCLSPLVPTDTSASYYPGIE------------------GCG 239
            .|::  ||.:  |....|...|.|   ...||........||.|                  .|.
Mouse   144 NCSK--FPPQ--NDHNHMCMEGPG---DEEVPLPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCV 201

  Fly   240 VRC--KDPLYTDD--EHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFL 300
            ::|  ...||:..  |...|...: || |:|.:|..|.|.||.|| .:...||...:.::::|:.
Mouse   202 LKCGYDAGLYSRSAKEFTDIWMAV-WA-SLCFISTTFTVLTFLID-SSRFSYPERPIIFLSMCYN 263

  Fly   301 IACVGWLLQFTSGSREDIVCRKDGTLRHSEPT----AGENLSCIVIFVLVYYFLTAGMVWFVFLT 361
            |..:.::::.|.| ||.|.|..:   ..:||.    ..:|..|.:||:|:|:|..|..:|:|.||
Mouse   264 IYSIAYIVRLTVG-RERISCDFE---EAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILT 324

  Fly   362 YAWHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMR 423
            ..|...|   .||  :.|:...||||:.||::|.|.||..:....||.:.:.|:|:||..|....
Mouse   325 LTWFLAAGLKWGH--EAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDAL 387

  Fly   424 AGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILV 488
            .|.::.||...::||..||..|:|.||.::  :|..|..:.::|:..:::::||.::|..|....
Mouse   388 TGFVVAPLFTYLVIGTLFIAAGLVALFKIR--SNLQKDGTKTDKLERLMVKIGVFSVLYTVPATC 450

  Fly   489 AIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVM 550
            .|||:   |.....||       :.:.|:   :.|:..:|           :|.:|.|   ||..
Mouse   451 VIACY---FYEISNWA-------LFRYSA---DDSNMAVE-----------MLKIFMSLLVGITS 491

  Fly   551 STWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAK 593
            ..|.|:..::.||     :||...:|...|:.:.| ....|.|
Mouse   492 GMWIWSAKTLHTW-----QKCSNRLVNSGKVKREK-RGNGWVK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	42/145 (29%)
		Frizzled	246..568	CDD:279827	97/333 (29%)
Fzd4	NP_032081.3	CRD_FZ4	42..167	CDD:143557	43/154 (28%)
		Frizzled	210..509	CDD:279827	99/338 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	499..504		0/4 (0%)
		PDZ-binding	535..537

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820