DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and Fzd3

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_067433.1	Gene:	Fzd3 / 14365	MGIID:	108476	Length:	666	Species:	Mus musculus

Alignment Length:	754	Identity:	164/754 - (21%)
Similarity:	284/754 - (37%)	Gaps:	180/754 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NTCFGSKL----PYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKI 158
            ||.|...|    ..:.::|.:..||....|:              |....:|||||::.|.|.:.
Mouse    42 NTTFMPNLLNHYDQQTAALAMEPFHPMVNLD--------------CSRDFRPFLCALYAPICMEY 92

  Fly   159 NGEDMVYLPSYEMCRITMEPCRILYNTTFFP--------KFLRCNETLFPTKC--------TNGA 207
            .   .|.||...:|:.....|..|......|        :|..|:|. :|...        |.||
Mouse    93 G---RVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEP-YPRLVDLNLVGDPTEGA 153

  Fly   208 RGMKFNGTGQCLSPLVPTDTSASY-YPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNL 271
            ........|......:..|....| :..:..|...|.:..:..:|.......||....|||.:.|
Mouse   154 PVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATL 218

  Fly   272 FVVSTFFIDWKNANKYPAVIVFYINLCF----LIACVGWLLQFTSGSREDIVCRKDGTLRHSEPT 332
            |...||.|| ....:||...:.:..:|:    ||..:|:||:      :.:.|......::...|
Mouse   219 FTFLTFLID-VTRFRYPERPIIFYAVCYMMVSLIFFIGFLLE------DRVACNASSPAQYKAST 276

  Fly   333 ---AGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAM---GHVQDRIDKKGSYFHLVAWSLP 391
               ...|.:|.::|:::|:|..||.||:|.||..|...|:   |  .:.|:||...||..||.:|
Mouse   277 VTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWG--SEAIEKKALLFHASAWGIP 339

  Fly   392 LVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFA 456
            ..|||..:|.::::|::|.|:||||..:.......:|.|||..:::|...:..|::.|
Mouse   340 GTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISL------- 397

  Fly   457 NDIK-----STSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKIS 516
            |.::     .....:|:...::|:||.::|.||.:||.|.|:..|..:...|..::.| ..|:
Mouse   398 NRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQ-ERCR-- 459

  Fly   517 SVFEEKSSCRIE----NRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVE 577
               |....|..:    :||.:.:..:..|.....||....|..:..:...|..:...:..||:|.
Mouse   460 ---EYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVN 521

  Fly   578 EVKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQ 642
            |    ..:|:.:.                                |...|...|.::      |.
Mouse   522 E----SRQVLQEP--------------------------------DFAQSLLRDPNT------PI 544

  Fly   643 CVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSVDSQVSVKIAEMKTKVAS-- 705
            ..|.|    |.:|..:|:|           :.|.:...|:.:|:        |...:.:||:|
Mouse   545 IRKSR----GTSTQGTSTH-----------ASSTQLAMVDDQRS--------KAGSVHSKVSSYH 586

  Fly   706 ----RSRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESSTSVESQVIALKKTTYPNASHKVGVF 766
                |||.......|.|..:.|..:     |..||..:.|..              ::||::...
Mouse   587 GSLHRSRDGRYTPCSYRGMEERLPH-----GSMSRLTDHSRH--------------SSSHRLNEQ 632

  Fly   767 AHHSSKK--QHNYTSSMKRRTANAGLDPSILNEFLQKNG 803
            :.|||.:  .:|..:.:...|:        :|..::::|
Mouse   633 SRHSSIRDLSNNPMTHITHGTS--------MNRVIEEDG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	31/142 (22%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	88/340 (26%)
Fzd3	NP_067433.1	CRD_FZ3	24..150	CDD:143558	27/125 (22%)
		Frizzled	193..512	CDD:279827	88/340 (26%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666		34/182 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810