| Sequence 1: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_067432.2 | Gene: | Fzd1 / 14362 | MGIID: | 1196625 | Length: | 642 | Species: | Mus musculus |
| Alignment Length: | 647 | Identity: | 156/647 - (24%) |
|---|---|---|---|
| Similarity: | 259/647 - (40%) | Gaps: | 142/647 - (21%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 12 IMMFLEVAILCLWVVADASASSAKFG--STTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWF 74
Fly 75 DGLDSRHIQCVRRARCYPTS--NATNTCFGSKLPYELSSLDLTDFHTEKE-LNDKLNDYYALKHV 136
Fly 137 PKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFF--PKFLRCNE--- 196
Fly 197 --------------------TLFPTKCTN-------GARGMKFNGTG-------QCLSPL-VPTD 226
Fly 227 TSASYYPGIEGCGVRCKDP------LYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNAN 285
Fly 286 KYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR----KDGTLRHSEPTAGENLSCIVIFVLV 346
Fly 347 YYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNS 408
Fly 409 IVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFG----LKHFANDIKSTSASNKIH 469
Fly 470 LIIMRMGVCALLTLVFILVAIACHVTEFRHADEW-----AQSFRQFIICKISSVFEEKSSC-RIE 528
Fly 529 N----------RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRK----KCGKEVV 576 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 36/176 (20%) |
| Frizzled | 246..568 | CDD:279827 | 94/348 (27%) | ||
| Fzd1 | NP_067432.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 26..45 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 76..99 | 5/25 (20%) | |||
| CRD_FZ1 | 107..233 | CDD:143574 | 27/135 (20%) | ||
| 7tmF_FZD1 | 294..641 | CDD:320375 | 97/370 (26%) | ||
| TM helix 1 | 313..338 | CDD:320375 | 8/24 (33%) | ||
| TM helix 2 | 347..368 | CDD:320375 | 2/20 (10%) | ||
| TM helix 3 | 398..424 | CDD:320375 | 8/25 (32%) | ||
| TM helix 4 | 441..457 | CDD:320375 | 9/15 (60%) | ||
| TM helix 5 | 479..508 | CDD:320375 | 9/28 (32%) | ||
| TM helix 6 | 528..555 | CDD:320375 | 9/26 (35%) | ||
| TM helix 7 | 591..616 | CDD:320375 | 5/24 (21%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 620..625 | 0/4 (0%) | |||
| PDZ-binding | 640..642 | 0/1 (0%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||