Protein Alignment smo and fz4

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: XP_319612.2
• Gene: fz4 / 1279837
• VectorBaseID: AGAMI1_009142
• Length: 616
• Species: Anopheles gambiae
• Alignment Length: 542
• Identity: 124/542 - (22%)
• Similarity: 189/542 - (34%)
• Gaps: 148/542 - (27%)

  Fly    96 ATNTCFGSK-------------LPYELSSL-DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPF 146
            ||||.|.::             :.|..:|| ::.....:.:.|..|..::.|... .|...::.|
Mosquito    23 ATNTDFSTQRTCEPIRIELCRGIGYNETSLPNIVGHELQSDANFTLQTFFPLIQF-GCSKQLKFF 86

  Fly   147 LCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTF-------------FPKFLRCNETL 198
            |||.:.|.|          .|...|   .:.|||.|.||..             :|..|.||.
Mosquito    87 LCATYVPMC----------TPKVSM---PIGPCRSLCNTVKNRCHPILQGFGFPWPSALDCNR-- 136

  Fly   199 FPTKCTNGARGMKFNGTGQCLSPLVPT--DTSASYYPGIEG---------------CGVRCKDPL 246
            ||.:  |....|...|.|:      |.  :...|..|..:|               |...|:..:
Mosquito   137 FPEE--NNHEHMCMQGPGE------PAEGEVLVSDRPSCQGLQRSNLYVQLNRSGRCAPLCEADI 193

  Fly   247 YTDDEHRQIHK--LIGWAGSICLLSNLFVVS-TFFIDWKNANKYPAVIVFYINLCFLIACVGWLL 308
            ..:...:...:  |..|  |:..|....|.: ...:..|..:|  :::...|:.|  :..|||.:
Mosquito   194 MFEQNEKHFAEVWLTSW--SVAALGTAIVATLCLILSTKRWDK--SLMPLVISHC--LVTVGWAV 252

  Fly   309 QFTSGSREDIVCRKDGTLRHSEPTAGENLS---CIVIFVLVYYFLTAGMVWFVFLTYAWH---WR 367
            ::.:| |....|..|..|........:.||   |...|:|.|||..:..||:..|...|.   .|
Mosquito   253 RWLAG-RNATACGYDPQLPGVALLLTDGLSTAPCAATFLLRYYFGLSAAVWWAILCLRWSKSVRR 316

  Fly   368 AMG---------HVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMR 423
            .:|         |.:.......:.|.|.||.:|.|||:..:....||.:.:.|.||:|  |.|.:
Mosquito   317 LLGTDLTSPADLHAEKPNSSHDTLFQLAAWGIPAVLTVIVLVARLVDADELFGSCFIG--NQSDK 379

  Fly   424 AGL--LLGPLCGVILIG-GYFITRGMVMLFGLKHFANDIKSTSASNKIH------------LIIM 473
            |.|  ::.||....:|| ||..|            |...|.::|...:|            |.|.
Mosquito   380 ALLTFVIVPLLSSWVIGSGYLFT------------AYLRKRSAAPPLVHNLPVHIHGMGKFLFIY 432

  Fly   474 RMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQL 538
            .:...|||.|:|.               |:|        |:.:.:.....|......||...|..
Mosquito   433 AVPSAALLMLMFY---------------EYA--------CRENWLHLPHPSLDSPLHPSRAPLWP 474

  Fly   539 HLLCLFSS---GIVMSTWCWTP 557
            .||..|..   |::.|.|...|
Mosquito   475 FLLRAFIELLVGVLASAWAVGP 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	36/151 (24%)
		7tmF_SMO_homolog	245..568	CDD:320158	82/349 (23%)
		TM helix 1	254..279	CDD:320158	5/27 (19%)
		TM helix 2	289..310	CDD:320158	5/20 (25%)
		TM helix 3	340..366	CDD:320158	9/28 (32%)
		TM helix 4	382..398	CDD:320158	8/15 (53%)
		TM helix 5	420..449	CDD:320158	10/31 (32%)
		TM helix 6	471..498	CDD:320158	6/26 (23%)
		TM helix 7	529..554	CDD:320158	8/27 (30%)
fz4	XP_319612.2	None