Protein Alignment smo and fz

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: XP_061510687.1
• Gene: fz / 1278320
• VectorBaseID: AGAMI1_008736
• Length: 620
• Species: Anopheles gambiae
• Alignment Length: 673
• Identity: 165/673 - (24%)
• Similarity: 270/673 - (40%)
• Gaps: 172/673 - (25%)

  Fly    13 MMFLEVAILCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGL 77
            |..|.||.| ||.|.....:|        .:.||...:.|.|         ...|.:.:....|.
Mosquito     1 MAALRVAAL-LWCVLLLPLAS--------TAIQQQLQQQETI---------VAHGGETETGSAGE 47

  Fly    78 DSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEK-ELNDKLNDYYALKHVPKCWA 141
            :.:|     ..||.|.:  ...|.|  :||..:.:.....||:: |...:::.|..|..: .|..
Mosquito    48 EFQH-----HNRCEPIT--IPFCIG--IPYNRTIMPNRFGHTKQDEAALEVHQYVPLVKI-DCSP 102

  Fly   142 AIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNT---------TF---FPKFLRC 194
            .::.|||.::.|.|        ..||      ..:.|||.|..:         ||   :|:.|.|
Mosquito   103 DLKFFLCLLYAPVC--------TILP------FPIPPCRSLCESARACESIMKTFNFPWPENLEC 153

  Fly   195 NE--------------------TLFPTKCTN---GARGMKFNGTGQ-----CLSPLVPT------ 225
            ::                    |..||....   |:.|....|.|.     ..:|.||.
Mosquito   154 SQFPEYGGEELCVSKHNASETPTPIPTSPAGVGAGSAGAGSAGGGYPMKTVAAAPYVPPHRKTSG 218

  Fly   226 -----DTSASYYPG----------------------------------IEGCGVRCKDPLYTDDE 251
                 ..||...||                                  .:.||..|....::::|
Mosquito   219 VVAGGGVSAGGPPGSGLVGTHRDLGFICPVQLKAPTLMGYQLTIGGKVTKDCGAPCNSMFFSENE 283

  Fly   252 HRQIHKLIG-WAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSR 315
            ...:...:| || ::|:.|.||.|.||.|| .:..:||...:.::.:|:||  ||.......|:.
Mosquito   284 RTVLKYWVGSWA-AVCVASCLFTVLTFLID-SSRFRYPERPIVFLAICYLI--VGCAYVAGLGAG 344

  Fly   316 EDIVCR-------KDGTLRH-SEPTAG--ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-- 368
            :.:.||       |.|.::. |..|.|  ::.||.|:|:.:|:...|...|:..|..||...|
Mosquito   345 DSVACREPFQSHIKIGRMQMLSTITQGHRQSTSCTVLFMALYFCCMAAFAWWACLALAWFLAAGL 409

  Fly   369 -MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLC 432
             .||  :.|:.:...||||||::|.|.||..:|..:|:|:.:.|:||||.::....|..||.||.
Mosquito   410 KWGH--EAIESRSHLFHLVAWAIPAVQTIFVLALGKVEGDVLSGVCFVGQLDTHSLAMFLLIPLV 472

  Fly   433 GVILIGGYFITRGMVMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACH 493
            ..:.|||.|:..|.|.||.    :||      ..:.::|:..:::|:|..:.|.::..|..:||.
Mosquito   473 IYLSIGGIFLLAGFVSLFRIRTVMKH------DGTRTDKLERLMLRIGFFSGLFILPSLGYLACL 531

  Fly   494 VTEFRHADEW-AQSFRQFIICKISSVFEEKSSCRI------ENRPSVGVLQLHLLCLFSSGIVMS 551
            ..|:.|.|:| .|..||  :|||.|:     .|..      :.:|...:..:..:|....|:..|
Mosquito   532 FYEYYHFDDWMIQWNRQ--MCKIFSI-----PCPAARHGPPDPKPIFHIYMVKYVCSMLVGVTSS 589

  Fly   552 TWCWTPSSIETWKRYIRKKCGKE 574
            .|.|:..::.:|:::..:..||:
Mosquito   590 VWLWSGKTVVSWRQFAERLQGKD 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	36/175 (21%)
		7tmF_SMO_homolog	245..568	CDD:320158	101/347 (29%)
		TM helix 1	254..279	CDD:320158	10/25 (40%)
		TM helix 2	289..310	CDD:320158	5/20 (25%)
		TM helix 3	340..366	CDD:320158	8/25 (32%)
		TM helix 4	382..398	CDD:320158	10/15 (67%)
		TM helix 5	420..449	CDD:320158	11/28 (39%)
		TM helix 6	471..498	CDD:320158	7/26 (27%)
		TM helix 7	529..554	CDD:320158	4/24 (17%)
fz	XP_061510687.1	None