| Sequence 1: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_009128.1 | Gene: | FZD10 / 11211 | HGNCID: | 4039 | Length: | 581 | Species: | Homo sapiens |
| Alignment Length: | 651 | Identity: | 148/651 - (22%) |
|---|---|---|---|
| Similarity: | 263/651 - (40%) | Gaps: | 164/651 - (25%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 23 LWVVADASASSAKFGS---TTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGLDSRHIQC 84
Fly 85 VRRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCA 149
Fly 150 VFKPKC-EKINGEDMVYLPSYEMCRITMEPCR-----ILYNTTF-FPKFLRCNETLFPTK----- 202
Fly 203 ----CTNGARGMKFNGTGQCLSPLVPTDT--SASYY------PGIEGC-----------GVRCKD 244
Fly 245 PLYT---------DDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFL 300
Fly 301 IACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH 365
Fly 366 WRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLL 427
Fly 428 LGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAI 490
Fly 491 ACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENR------------PSVGVLQLHLLCL 543
Fly 544 FSSGIVMSTWCWTPSSIETWK----RYIRKKCGKE---------VVEEVKMP------KHKVIAQ 589
Fly 590 T 590 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 27/150 (18%) |
| Frizzled | 246..568 | CDD:279827 | 95/351 (27%) | ||
| FZD10 | NP_009128.1 | CRD_FZ10 | 30..156 | CDD:143571 | 28/182 (15%) |
| 7tmF_FZD10 | 217..535 | CDD:320165 | 92/339 (27%) | ||
| TM helix 1 | 226..251 | CDD:320165 | 9/25 (36%) | ||
| TM helix 2 | 260..281 | CDD:320165 | 4/20 (20%) | ||
| TM helix 3 | 310..336 | CDD:320165 | 10/25 (40%) | ||
| TM helix 4 | 353..369 | CDD:320165 | 10/15 (67%) | ||
| TM helix 5 | 391..420 | CDD:320165 | 10/28 (36%) | ||
| TM helix 6 | 440..467 | CDD:320165 | 8/26 (31%) | ||
| TM helix 7 | 497..522 | CDD:320165 | 5/24 (21%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 526..531 | 0/4 (0%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 560..581 | 4/18 (22%) | |||
| PDZ-binding | 579..581 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D509772at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.820 | |||||