Protein Alignment smo and fzd4

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: XP_002936589.1
• Gene: fzd4 / 100497693
• XenbaseID: XB-GENE-478210
• Length: 523
• Species: Xenopus tropicalis
• Alignment Length: 550
• Identity: 153/550 - (27%)
• Similarity: 244/550 - (44%)
• Gaps: 110/550 - (20%)

  Fly    89 RCYP--TSNATNTCFG-SKLP----YEL---SSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAI 143
            ||.|  .|...|..:. :|:|    :||   :.|.||.|       ..|..|       .|.:.:
 Frog    30 RCDPIRISMCQNLGYNVTKMPNLVGHELQADAELQLTTF-------TPLIQY-------GCSSQL 80

  Fly   144 QPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCR-ILYNTTF-FPKFLRCNETLFPTKCTN 205
            |.|||:|:.|.| ||||   :...|...||......|. :|....| :|:.|.|::  ||.:  |
 Frog    81 QFFLCSVYVPMCTEKIN---IPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSK--FPPQ--N 138

  Fly   206 GARGMKFNGTG------QCLSPLVPTDTSASYYPGIE---------GCGVRC--KDPLYT--DDE 251
            ....|...|.|      ...:|::|.:...|:.|..:         .|.::|  ...||:  ..|
 Frog   139 DHNHMCMEGPGDDEVPVHSKTPVLPGEDCNSFGPNSDQYTWVKRSMNCVLKCGYDSGLYSRLSKE 203

  Fly   252 HRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSRE 316
            ...|...: || |:|.:|..|.|.||.|| .:...||...:.::::|:.|..:.::::.|.| ||
 Frog   204 FTDIWMAV-WA-SLCFISTAFTVLTFLID-SSRFCYPERPIIFLSMCYNIYSIAYIVRLTVG-RE 264

  Fly   317 DIVCRKDGTLRHSEPT----AGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQD 374
            .|.|..:   ..:||.    ..:|..|.:||:|:|:|..|..:|:|.||..|...|   .||  :
 Frog   265 RISCDFE---EAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGH--E 324

  Fly   375 RIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGG 439
            .|:...||||:.||::|.|.||..:....||.:.:.|:|:||..|.....|.::.||...::||.
 Frog   325 AIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNIDALTGFVVAPLFTYLVIGT 389

  Fly   440 YFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWA 504
            .||..|:|.||.::  :|..|..:.::|:..:::::||.::|..|.....|||:   |.....|
 Frog   390 LFIAAGLVALFKIR--SNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACY---FYEISNW- 448

  Fly   505 QSFRQFIICKISSVFE---EKSSCRIENRPSVGVLQLHLLCLFSS---GIVMSTWCWTPSSIETW 563
                        :||.   :.|:..:|           :|.:|.|   ||....|.|:..::.||
 Frog   449 ------------NVFRYTADDSNMAVE-----------MLNIFMSLLVGITSGMWIWSAKTLHTW 490

  Fly   564 KRYIRKKCGKEVVEEVKMPKHKVIAQTWAK 593
                 :||...:|...|: |.|.....|.|
 Frog   491 -----QKCTNRLVNSGKV-KRKKRVDGWVK 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	42/150 (28%)
		Frizzled	246..568	CDD:279827	97/336 (29%)
fzd4	XP_002936589.1	CRD_FZ4	28..153	CDD:143557	42/143 (29%)
		7tmF_FZD4	195..495	CDD:320166	99/342 (29%)
		TM helix 1	204..229	CDD:320166	10/26 (38%)
		TM helix 2	238..259	CDD:320166	2/20 (10%)
		TM helix 3	289..315	CDD:320166	11/25 (44%)
		TM helix 4	332..348	CDD:320166	9/15 (60%)
		TM helix 5	370..399	CDD:320166	9/28 (32%)
		TM helix 6	419..446	CDD:320166	8/29 (28%)
		TM helix 7	456..481	CDD:320166	7/35 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920