DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and smo

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	XP_002931911.2	Gene:	smo / 100491644	XenbaseID:	XB-GENE-487420	Length:	815	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	283/808 - (35%)
Similarity:	448/808 - (55%)	Gaps:	113/808 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QCVRRARCYPTSNATNTCFGSKLPYELSSLDLT-DFHTEKELNDKLNDYYALKHVPKCWAAIQPF 146
            :|.:...|.|..  .|.|.||.|||.|:|..|. |..|::|::|||..:..|::.|:||.||:|.
Frog    36 KCKKTTTCEPLK--YNVCLGSVLPYALTSTVLAEDSSTQEEIHDKLLLWSGLRNAPRCWDAIRPL 98

  Fly   147 LCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFPTKCTNGARGMK 211
            ||||:.||||  .|:  |.|||..:|:.|..||.|:.....:|.||:|....||..|:|..:.:|
Frog    99 LCAVYMPKCE--GGK--VELPSQSLCQTTRVPCAIVARERGWPDFLKCTTDHFPDGCSNEIQTVK 159

  Fly   212 FNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVST 276
            ||.:|||.:|||.||...|:|..:||||::|::||:|..|||::|..|....|:.:....|.::|
Frog   160 FNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTKKEHREMHVYIAIFSSVTIFCTFFTLAT 224

  Fly   277 FFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIV 341
            |..||||:|:|||||:||:|.||.:..:|||.||..|:|::||||.|||:|..|||:.|.|||::
Frog   225 FLSDWKNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARDEIVCRGDGTMRLGEPTSNETLSCVI 289

  Fly   342 IFVLVYYFLTAGMVWFVFLTYAWH--WRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEV 404
            |||:|||.:.:|::|||.||||||  ::|:|.....:..|.|||||:.||:|.|||:..:|.::|
Frog   290 IFVIVYYAMMSGVIWFVMLTYAWHTSFKALGTTHQPLSGKTSYFHLITWSIPFVLTVAILAVAQV 354

  Fly   405 DGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIH 469
            ||:|:.|||||||.|:..|||.:|.|:..|:::||||:.||::.||.:|.....:.|..|::||:
Frog   355 DGDSVSGICFVGYKNYHYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKIN 419

  Fly   470 LIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSS-----CRIEN 529
            ..::|:|:...|...|:|:...||..:|.:..||.:|||::::|:.:....|:::     |.|:|
Frog   420 ETMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAEQTNKPIPECEIKN 484

  Fly   530 RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKR 594
            |||:.|.:::|..:|.:||.||||.||.::|..|||...:..|:...|..::.|.|:||:.::||
Frog   485 RPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKRAWCRILGRSDDEPKRIKKSKMIAKAFSKR 549

  Fly   595 KDF--EDKGRLSITLYN-THTDPV-GLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAAT 655
            |:.  ..:..||.:|:. :|..|| |||||:|:.::    |:||.||.::.:.|.||.|:
Frog   550 KELLNNPEKELSFSLHTVSHEGPVAGLNFDINEPSA----DMSSAWAQHVTKMVARRGAI----- 605

  Fly   656 GNSSSHGPRKNSLDSEISVS------------------------VRHVSVESRR----------- 685
                        |..::||:                        |:.:|.:.||
Frog   606 ------------LPQDVSVTPVATPVPPEEREQWLIEGDLPQGMVKKMSKKKRRRKKKEIQPLEE 658

  Fly   686 ----NSVDSQVSVKIAE-----MKTKVASRSRGKH-------GGSSSNRRTQRRRDY---IAAAT 731
                :...|:.:..:..     :||.:.:||:...       |.....:|...|::.   :.:..
Frog   659 NTGMDHFHSRANTAVPRLPKLPLKTGLVTRSKDPQEIDETLPGSYREFKRLPNRQEKLYPVESVN 723

  Fly   732 GKSSRRRESSTSVESQVIALKK---------TTYPNASHKVGVFAHHSSKKQHNY---TS-SMKR 783
            ......|...:::.|...|..|         |.:|...|. |||.:.:|....|:   || |.:.
Frog   724 NNLGYTRYPQSNMMSHPFAADKMPHTDQSRVTYFPVPKHD-GVFQYSNSNSYSNHMDLTSYSGRT 787

  Fly   784 RTANAGLDP-----SILN-EFLQKNGDF 805
            :...||:.|     :::: |.:..:.||
Frog   788 QARRAGIPPMHSRANLMDAELMDTDSDF 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	57/135 (42%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	146/328 (45%)
smo	XP_002931911.2	CRD_SMO	39..169	CDD:143560	54/130 (42%)
		7tmF_SMO_homolog	193..523	CDD:320158	148/336 (44%)
		TM helix 1	202..227	CDD:320158	7/24 (29%)
		TM helix 2	237..258	CDD:320158	11/20 (55%)
		TM helix 3	288..314	CDD:320158	14/25 (56%)
		TM helix 4	332..348	CDD:320158	10/15 (67%)
		TM helix 5	370..399	CDD:320158	13/28 (46%)
		TM helix 6	421..448	CDD:320158	8/26 (31%)
		TM helix 7	484..509	CDD:320158	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	333	1.000	Domainoid score	I1147
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4115
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1289
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114070at33208
OrthoFinder	1	1.000	-	-		FOG0008402
OrthoInspector	1	1.000	-	-		oto102757
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160