DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and fzd5

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	XP_004917802.1	Gene:	fzd5 / 100488110	XenbaseID:	XB-GENE-479707	Length:	559	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	133/507 - (26%)
Similarity:	223/507 - (43%)	Gaps:	99/507 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCR--- 180
            |:.|...:::.::.|. |.:|...::.|||:::.|.|          ||.|   |..:.|||
Frog    59 TQDEAGMEVHQFWPLV-VIQCSLDLKFFLCSMYTPIC----------LPDY---RKPLPPCRSVC 109

  Fly   181 ---------ILYNTTF-FPKFLRCNETLFP------TKCTNGARGMKFN---------------- 213
                     ::....| :|:.:.|:.  .|      |.|      |.:|
Frog   110 ERAKAGCSPLMRKYGFAWPERMNCDR--LPEHGDPDTLC------MDYNWTETTTTPPPTHPPKV 166

  Fly   214 --------GTGQCLSPLVP-TDTSASYYPGIE-----GCGVRCKDPLYTDDEHRQIHKLIGWAGS 264
                    |..:|..|.:. |..|...|..|:     .|.:.|..|.:|.||.......||....
Frog   167 KTPSSDCDGVCKCREPFLSITRESHPLYNRIKTGQVPNCAMPCFQPYFTQDEKTFATFWIGLWSI 231

  Fly   265 ICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHS 329
            :|.:|....|:||.||.:.. :||...:.:::.|:|...:|::::...| .|::.|.||..  |.
Frog   232 LCFISTFTTVATFLIDMERF-RYPERPIIFLSACYLFVSIGYIVRLIVG-HENVACNKDHI--HY 292

  Fly   330 EPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRIDKKGSYFHLVAWSLPLV 393
            | |.|..| |.|:|:|:|:|..|..:|:|.||:.|...| |....:.|.....|||:.||.:|.|
Frog   293 E-TTGPAL-CTVVFLLIYFFGMASSIWWVILTFTWFLAAGMKWGNEAIASYSQYFHMAAWLIPSV 355

  Fly   394 LTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFAND 458
            .:|..:|.|.|||:.:.||||||..|.....|.:|.||...:..|..|:..|.|.||.::....
Frog   356 KSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRSVIK- 419

  Fly   459 IKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKS 523
             :..:.::|:..:::|:|:.::|..|...:.:||::.|..:.:.|.::              ...
Frog   420 -QGGTKTDKLEKLMIRIGIFSVLYTVPATIVVACYIYEQHYREHWEKA--------------HNC 469

  Fly   524 SC---RIENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKC 571
            ||   :...||...|..| :.:||. .||....|.|:..::|:|||:..:.|
Frog   470 SCPGDKKRYRPDYAVFMLKYFMCLV-VGITSGVWIWSGKTLESWKRFTGRCC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	27/144 (19%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	97/326 (30%)
fzd5	XP_004917802.1	CRD_FZ5	29..153	CDD:143569	25/115 (22%)
		7tmF_FZD5	212..517	CDD:320377	98/327 (30%)
		TM helix 1	221..246	CDD:320377	7/24 (29%)
		TM helix 2	255..276	CDD:320377	3/20 (15%)
		TM helix 3	301..327	CDD:320377	11/25 (44%)
		TM helix 4	344..360	CDD:320377	8/15 (53%)
		TM helix 5	382..411	CDD:320377	8/28 (29%)
		TM helix 6	431..458	CDD:320377	7/26 (27%)
		TM helix 7	478..503	CDD:320377	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920