Protein Alignment smo and fzd9

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: XP_004911821.1
• Gene: fzd9 / 100487936
• XenbaseID: XB-GENE-478317
• Length: 587
• Species: Xenopus tropicalis
• Alignment Length: 603
• Identity: 142/603 - (23%)
• Similarity: 251/603 - (41%)
• Gaps: 131/603 - (21%)

  Fly    86 RRARCYPTSNATNTCFGSKLPYELSSL-DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCA 149
            |.|:|.|..  ...|.|  :.|.::.: :.....:::|...||.::..|... .|...::.|||:
 Frog    34 REAKCEPIQ--IPMCQG--IGYNMTRMPNYVGHESQEEAAAKLQEFAPLVEY-GCHIHLRFFLCS 93

  Fly   150 VFKPKC-EKINGEDMVYLPSYE-MCRITMEPCRILYNT--TFFPKFLRCNETLFPTK-------- 202
            ::.|.| |:::    ..:|:.: ||....:.|..:..:  ..:|:.|.|:.  .|:|
 Frog    94 LYAPMCTEQVS----TSIPACKPMCEAARQKCAPIMESFQYVWPESLDCDR--LPSKNDPHALCM 152

  Fly   203 -----CTNGARGMKFNGTGQCLSPLVPTDTSASYYPGIEGCGV--RCKDP---LYTD-------- 249
                 .|||  ....||.|  :.|:.|....    |...|.|:  ||.:|   :|.:
 Frog   153 EAPENATNG--DPPTNGHG--MLPVAPRPPR----PSGSGIGISSRCANPDKFMYVERSGVCAPR 209

  Fly   250 ------------DEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIA 302
                        |:...:..:..|:| :|.:|..|.|.||.:. ....:||...:.::::|:.:.
 Frog   210 CIPGVDVYWSSGDKDFALVWMAAWSG-LCFISTAFTVFTFLLH-PQRFQYPEKPIIFLSMCYNVY 272

  Fly   303 CVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWR 367
            ...:|::..:|: ..|.|.::|...:......|:..|.::|:::|||..|..:|:|.||..|...
 Frog   273 STAFLIRAAAGA-PSIACDREGGAPYLIREGLESSGCTLVFLILYYFGMASSLWWVVLTLTWFLA 336

  Fly   368 A---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLG 429
            |   .||  :.|:..||||||.||.:|.:.||..:...:|.|:.:.|:|:||..:.|...|.:|.
 Frog   337 ASKKWGH--EAIESHGSYFHLAAWGIPAIKTIIILTMRKVGGDELTGLCYVGGSDPSALTGFVLV 399

  Fly   430 PLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIAC 492
            ||...::.|..|:..|.|.||.::.    :..|..:|  |:..:::::||.::|..|.....|.|
 Frog   400 PLSCYLVTGTSFLLTGFVALFHIRR----VMKTGGTNTEKLEKLMVKIGVFSILYTVPATCIIVC 460

  Fly   493 HVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRI------------ENRPSVGVLQLHLLCLFS 545
            ...|..:...|....|:             .|||.            .:.|||.|..|.:....:
 Frog   461 CFYERLNLAHWDSRARE-------------ESCRTVPGSARPDCNLPHSIPSVAVFMLKIFMSLA 512

  Fly   546 SGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLS------ 604
            .||....|.|:..:::.|:..:   |.:.:||        |.|:|..|     .:|.|.
 Frog   513 VGITSGVWVWSSKTLQAWQGIL---CQRRLVE--------VGARTRGK-----PQGGLGVPCSLG 561

  Fly   605 --------ITLYNTHTDP 614
                    :||....|||
 Frog   562 SCPYKPPPVTLQVAKTDP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	33/152 (22%)
		Frizzled	246..568	CDD:279827	87/358 (24%)
fzd9	XP_004911821.1	CRD_FZ	34..159	CDD:382974	27/135 (20%)
		7tmF_FZD9	216..535	CDD:320164	86/343 (25%)
		TM helix 1	225..250	CDD:320164	8/25 (32%)
		TM helix 2	259..280	CDD:320164	2/20 (10%)
		TM helix 3	309..335	CDD:320164	10/25 (40%)
		TM helix 4	352..368	CDD:320164	9/15 (60%)
		TM helix 5	390..420	CDD:320164	9/29 (31%)
		TM helix 6	439..466	CDD:320164	7/26 (27%)
		TM helix 7	496..521	CDD:320164	7/24 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920