DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and Fzd7

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_001258114.1	Gene:	Fzd7 / 100360552	RGDID:	2321905	Length:	572	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	132/525 - (25%)
Similarity:	225/525 - (42%)	Gaps:	109/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   |....|...:|....:.|..
  Rat    73 HTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL---DQAIPPCRSLCERARQGCEA 133

  Fly   182 LYNTTFF--PKFLRCNETLFPT----------KCTNGARGMKFNGTGQCLSPLVPTDTSASYYP- 233
            |.|...|  |:.|||..  ||.          ..::|:.|...:.|....:|.:|.....:..|
  Rat   134 LMNKFGFQWPERLRCEN--FPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPS 196

  Fly   234 ---------------------------GIEGCGVRCKDP------LYTDDEHRQIHKLIGWAG-- 263
                                       |...||..| :|      :|..:|.|:..:|  |.|
  Rat   197 DGRGRWSFPFSCPRQLKVPPYLGYRFLGERDCGAPC-EPGRANGLMYFKEEERRFARL--WVGVW 258

  Fly   264 -SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACV----GWLLQFTSGSREDIVC--- 320
             .:|..|.||.|.|:.:|.:..: ||...:.:::.|:.:..|    |:||:      :..||
  Rat   259 SVLCCASTLFTVLTYLVDMRRFS-YPERPIIFLSGCYFMVAVAHVAGFLLE------DRAVCVER 316

  Fly   321 -RKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGS 381
             ..||....::.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....
  Rat   317 FSDDGYRTVAQGTKKE--GCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGH--EAIEANSQ 377

  Fly   382 YFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGM 446
            ||||.||::|.|.|||.:|..:|||:.:.|:|:||..:.....|.:|.||...:.||..|:..|.
  Rat   378 YFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGF 442

  Fly   447 VMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSF 507
            |.||.    :||      ..:.:.|:..:::|:||.::|..|...:.:||:..|....:.|.
  Rat   443 VSLFRIRTIMKH------DGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE--- 498

  Fly   508 RQFII--CKISSV------FEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWK 564
            |.:::  ||..:|      |...|       |...|..:..|.....||....|.|:..::::|:
  Rat   499 RTWLLQTCKSYAVPCPPGHFSPMS-------PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWR 556

  Fly   565 RYIRK 569
            |:..:
  Rat   557 RFYHR 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	28/115 (24%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	96/347 (28%)
Fzd7	NP_001258114.1	CRD_FZ7	45..169	CDD:143575	25/101 (25%)
		7tmF_FZD7	241..571	CDD:320374	96/350 (27%)
		TM helix 1	251..275	CDD:320374	9/25 (36%)
		TM helix 2	284..305	CDD:320374	2/20 (10%)
		TM helix 3	335..357	CDD:320374	7/21 (33%)
		TM helix 4	378..394	CDD:320374	10/15 (67%)
		TM helix 5	416..439	CDD:320374	7/22 (32%)
		TM helix 6	470..492	CDD:320374	7/21 (33%)
		TM helix 7	521..546	CDD:320374	6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810