DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3345 and Fsip2

DIOPT Version :9

Sequence 1:	NP_608509.1	Gene:	CG3345 / 33192	FlyBaseID:	FBgn0031240	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_038962371.1	Gene:	Fsip2 / 680315	RGDID:	1593013	Length:	6958	Species:	Rattus norvegicus

Alignment Length:	863	Identity:	172/863 - (19%)
Similarity:	299/863 - (34%)	Gaps:	314/863 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SYKTGLPINSLPGWEL--IPLNCKLPMLKCPGNQVIFSKNKIGQDFKSGKQEFE-----CSVTEH 81
            ::||  ||..:...:|  :||..||||:  ||...::....|.:........|.     |.:.|
  Rat    35 AHKT--PIPGVGAAQLLDLPLGVKLPMI--PGTDTVYFTTNISEKLFRPSYGFNLTDPYCRLLE- 94

  Fly    82 IPEYNPLHDSNLKTFYSNERNLKRLRENGEITQDNDVICNLKDFNQHRQELHKSQLYYILQAYKR 146
             .:|..|||.:|:|:|..:..|:||::.|.||.:|.::|:|::.|::||.|...:|.: .:.|.|
  Rat    95 -TQYKSLHDPHLRTYYKRKDILRRLKKGGYITSNNKIVCSLRELNKYRQYLTSLKLDF-ERNYLR 157

  Fly   147 RE---SEQYDRM----LIANAESITKKDHQNLAARHQCTEEVLARKKLQEQERHERKVHLLNITY 204
            .:   |:|..|:    .:.:...:|:..:..|....||         :::|||..|..:|..|:.
  Rat   158 EQQLISKQLHRLQETSQLPHCSDVTRFQNWLLQDNSQC---------IKDQERLLRHRYLDMISK 213

  Fly   205 EKFKRLENLATMQNMLLEHRKMLTNMRVAAHISMCQDLMRKLLIKQKKLFQFKKDRFNKNMRILR 269
            | .::||..|..|.:|...|:.......|         .:||.:::|...::|    .|.|.:|.
  Rat   214 E-LEQLERTAEEQRLLRMDREERRQREYA---------RKKLSLRRKIEEEWK----TKEMMLLT 264

  Fly   270 KQRLVKNTEHQIQSWRKRLDERIANQRRIEYLLQEVEKEREAFIDRHKAHYREKWQ--RIQDEIK 332
            |          |....|| ::|:..|||..  .:|.:::::|.:::..|::.:|.|  .::|::.
  Rat   265 K----------IGEDVKR-EQRVEEQRRRS--REESDRKKQAMLEKKMAYHLQKMQDTGLKDDMG 316

  Fly   333 ----ERAQKAITARQPKRKRRKKKKSTLQERKPSFCDEYQATFEG-------------------- 373
                |...:.:....|     ||||..|.:.|..:.|..|..::|
  Rat   317 RSGFEYKGQTMFESSP-----KKKKRPLDDIKVVYPDSDQKAYKGASGQVSSTVNQSQSSSKNVT 376

  Fly   374 -LLDSDLCY------------------------------------------ALNAAIAMEGQTAL 395
             :..|.:.|                                          ..||.::   ||:|
  Rat   377 KVSGSSVAYPADVQNSSSEQKRNGITKKLSDERVPGTTSTRDSVISAQESPTKNARLS---QTSL 438

  Fly   396 -----------------------------SFAP-----DDPIYKAAQYILDYIISGLNDDLSEDE 426
                                         |.||     ..|:|...|..|.:.   |.:.::.:|
  Rat   439 IHHKEEKMQSDWNGRPSKKSSYVGEPGSQSCAPPPNIFSSPVYSNMQQNLQHC---LKEKVTSEE 500

  Fly   427 CALQVLISRIKDFVCDAKKYVHYKA------------YQII------------------GFA-RD 460
              |..:|..|..:|......:.|.|            ||:.                  ||. |.
  Rat   501 --LNSIIQNIMTWVVATVTSILYPAITKYEERVQSNTYQVSDDSDLSSDSSSFCSTCSEGFTYRS 563

  Fly   461 HKA---------------MEVPPSMAKQPKNHSR---------------ASHVSFSGVA-----S 490
            :.|               ::.|||..|.|..|..               ||.|:|:..:     .
  Rat   564 YTAKTFQADPCAFATDVPLKKPPSPVKTPSAHVEKTVIDQTYEKKGQDIASQVNFNKTSLDYPFP 628

  Fly   491 TIGVGSYEIHPFVDVRPCSERRATPAGSLASLVVSQIGEQVIQDKVRLPHLNRNQIVFIEHYLVK 555
            .||....:.|....:..|::..........||                      :|.|:  |..|
  Rat   629 KIGSSKSDSHLLTSLETCTKTSKDATTETESL----------------------EIPFL--YDKK 669

  Fly   556 FK-RDLLVGLDKLVFAAIQCHFENRMMEVREELLLLDRNYLFEQIARGILSYAVNPLNYQSVL-- 617
            .| .|.:..| |.||...:||.:.      |..|:|:.  :|::|... ||.|:..|:  ||.
  Rat   670 AKAMDEMKNL-KNVFVNFKCHLKG------ETQLILES--IFQEIMSD-LSQAIPSLS--SVTAE 722

  Fly   618 -----------KLAVSVQSCEIIWELQQTML------------------------KPGIDPRGQN 647
                       :...:|..|.:..|:.:.||                        ||.:...|:
  Rat   723 VFVDQTDAEREEFLSNVDICSVASEIVENMLEKLECAVERKYVQIFSQEDLSVEIKPSLSTSGE- 786

  Fly   648 HPVSCGTEQERETLALCI 665
            :..|..|:...:||:..:
  Rat   787 YFSSIETKPSEDTLSFTL 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3345	NP_608509.1	None
Fsip2	XP_038962371.1	DUF5401	<135..>335	CDD:375164	52/241 (22%)
		FSIP2	4040..>4582	CDD:406266
		FSIP2	4450..>4917	CDD:406266
		FSIP2	5961..6827	CDD:406266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44529
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000