DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3345 and FSIP2

DIOPT Version :9

Sequence 1:	NP_608509.1	Gene:	CG3345 / 33192	FlyBaseID:	FBgn0031240	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_775922.3	Gene:	FSIP2 / 401024	HGNCID:	21675	Length:	6907	Species:	Homo sapiens

Alignment Length:	762	Identity:	142/762 - (18%)
Similarity:	267/762 - (35%)	Gaps:	247/762 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLNCKLPMLKCPGNQVIFSKNKIGQDFKSGKQEFE-----CSVTEHIPEYNPLHDSNLKTFYSN 99
            :||..|||::  ||:..:|.....|:........|.     |.:.|:  :|..|||.:||.:|..
Human    51 LPLGVKLPVI--PGSNAVFYTTNFGEKLFRPSYGFNLTDPYCRLLEN--QYKSLHDPHLKAYYKR 111

  Fly   100 ERNLKRLRENGEITQDNDVICNLKDFNQHRQELHKSQLYYILQAYKRRESEQYDRMLIANAESIT 164
            :..||||::.|.||.:|.|:|.|::.|::||.|...:|             .::|..|.....:.
Human   112 KDILKRLKKGGYITSNNKVVCTLRELNKYRQYLTSLKL-------------DFERNYIKEQRILA 163

  Fly   165 KKDH----QNLAARHQCTEEVL------ARKKLQEQERHERKVHLLNITYEKFKRLENLATMQNM 219
            |:.|    .|...:|....:|.      ..:.:::|||..|. ..|::...|.::||..|..|.:
Human   164 KQLHNIPENNQIPQHCDVAQVQNWLLKEGTESIKDQERLMRH-RYLDMISRKLEQLERTAEEQRL 227

  Fly   220 LL---EHRKMLTNMRVAAHISMCQDLMRKLLIKQKKLFQFKKDRFNKNMRILRKQRLVKNTEHQI 281
            .|   |.|:...:.|            |||.:::|...::|    .|.|.:|  .|:.::.:.:
Human   228 FLMDREERRQREHTR------------RKLTLRRKIEEEWK----TKEMLLL--TRMAEDVKRE- 273

  Fly   282 QSWRKRLDERIANQRRIEYLLQEVEKEREAFIDRHKAHYREKWQRI--------QDEIKERAQKA 338
                :|::|:....|      :|.:::::..:::..|::.:|.|..        ::..|.|.|..
Human   274 ----ERIEEQQHRNR------EESDRKKQDLLEKKMAYHLQKMQDTGFNGEDIGKNTFKYRGQDG 328

  Fly   339 ITARQPKRKRRKKK----------KSTLQE--------------------RKPSFCDEYQATF-- 371
             |...||.|::..:          ::|.:|                    :|.|....|||..
Human   329 -THASPKNKKKTSEDIMLVYPAGDQNTYKETHGHTANAAHQRQNSSNNFTKKNSASVVYQADVQD 392

  Fly   372 -------EGLLD-SDLCYALNAAIAMEGQTALSFAPDDP---IYKAAQYILD------------- 412
                   :|::. :...:.....|.:.||.::..|...|   ..:.:|..||
Human   393 NGINQKRDGMVSKNSSIFDDRGGINISGQGSIISAQVSPTRNFSRVSQAFLDPSKEEKETNADWD 457

  Fly   413 --------YII-SG---------------------------LNDDLSEDECALQVLISRIKDFVC 441
                    |:. ||                           |.:.::.:|  |.::|..:..:|.
Human   458 GRPTKRSSYLCESGPQAHATDPGIFSSPVYTNMQQNLLQNCLQEKVTSEE--LNIIIQNVMTWVV 520

  Fly   442 DAKKYVHYKAYQIIGFARDHKAMEVPPSMAKQPKNHSRASH------------VSFSGVAS---- 490
            .....:.|                  |::.|..|.....::            .||....|
Human   521 ATVTSILY------------------PAITKYEKRLQNNTYPVSDDSILSSDSSSFCSTCSEDFT 567

  Fly   491 -----TIGVGSYEIHPFVDVRPCSERRAT-----PAGSLASLVVSQI----GEQVIQDKVRLPHL 541
                 :....:::..|...|...|.||.|     |...:...||.:.    |:.:|...    ..
Human   568 YRSYTSATTKTFQAEPCAFVVDTSVRRPTTPIKPPPAHVEKTVVGKTCHIKGQSIISKH----KY 628

  Fly   542 NRNQIVFI----------EHYLVKFK------RDLLVGLDKLVFAAIQCHFENRMMEVREELLLL 590
            |:..:::.          .|.|..|:      :|.....|.| .:::.|....:.|:..:.|..:
Human   629 NKTNLLYSYPKLRSCKSDSHLLASFETGTKKSKDATTETDSL-GSSLHCDKTAKAMDEMKNLKNV 692

  Fly   591 DRNY----------LFEQIARGILSYAVNPLNYQSVLKLAVSVQSCE 627
            ..|:          :.|.|.|.|:|.....:...|.:...|.|:.||
Human   693 FVNFKCYLKGETEVILESILREIMSDLTQAIPSLSSVTAEVFVEQCE 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3345	NP_608509.1	None
FSIP2	NP_775922.3	MAP7	<213..307	CDD:283355	24/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..292		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..472		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1573
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3202..3257
		FSIP2	4043..>4581	CDD:292411
		FSIP2	4686..>5231	CDD:292411
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5650..5672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5725..5781
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5850..5880
		FSIP2	5901..6774	CDD:292411
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6852..6874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto88526
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030