DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3345 and Fsip2

DIOPT Version :9

Sequence 1:	NP_608509.1	Gene:	CG3345 / 33192	FlyBaseID:	FBgn0031240	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001357195.1	Gene:	Fsip2 / 241516	MGIID:	2664111	Length:	6993	Species:	Mus musculus

Alignment Length:	867	Identity:	163/867 - (18%)
Similarity:	295/867 - (34%)	Gaps:	327/867 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YKTGLPINSLPGWEL--IPLNCKLPMLKCPGNQVIFSKNKIGQDFKSGKQEFE-----CSVTEHI 82
            :||  ||..:...:|  :||..||||:  ||...::....|.:........|.     |.:.|
Mouse    36 HKT--PIPGVGAAQLLDLPLGVKLPMI--PGTDTVYFTTNISEKLFRPSYGFNLSDPYCRLLE-- 94

  Fly    83 PEYNPLHDSNLKTFYSNERNLKRLRENGEITQDNDVICNLKDFNQHRQELH-----------KSQ 136
            .:|..|||.:|:|:|..:..|:||::.|.||.:|.::|:|::.|::||.|.           :.|
Mouse    95 TQYKSLHDPHLRTYYKRKDILRRLKKGGYITSNNKIVCSLRELNKYRQYLTSLKLDFERNYLREQ 159

  Fly   137 LYYILQAYKRRESEQYDR----------MLIANAESITKKDHQNLAARHQCTEEVLARKKLQEQE 191
            .....|.:|.:|:.|...          :|..|..||  ||.:.| .||:..:  :..|:|::.|
Mouse   160 QLISKQLHKLQETSQLPHCSDVTRFQNWLLQDNTHSI--KDQERL-LRHRYLD--MISKELEQLE 219

  Fly   192 RHERKVHLLNITYEKFKRLENLATMQNMLLEHRKMLTNMRVAAHISMCQDLMRKLLIKQKKLFQF 256
            |...:..||.|..::.::.|..          ||.||             |.||:
Mouse   220 RTAEEQRLLRIDRDERRQREYT----------RKKLT-------------LRRKI---------- 251

  Fly   257 KKDRFNKNMRILRKQRLVKNTEHQIQSWRKRLDERIANQRRIEYLLQEVEKEREAFIDRHKAHYR 321
            :::...|.|.:|.|          |....|| :::|..|||..  .:|.:::::|.:::..|::.
Mouse   252 EEEWKTKEMMLLTK----------IGEDVKR-EQKIEEQRRKS--REESDRKKQAMLEKKMAYHL 303

  Fly   322 EKWQ--RIQDEIKE-----RAQKAITARQPKRKRRK----------------------------- 350
            :|.|  .::|:|..     |.|...|.....:||:|
Mouse   304 QKMQDTGLKDDIGRNGFDYRGQNGTTFESSSKKRKKQFDDIKIVYPDGDQKAYRGTSGQVSATVN 368

  Fly   351 -----------------------------KKKSTLQERKPSFCDEYQ----ATFEGLLDSDLCYA 382
                                         :|:|.:.:|   ..||..    :..|.::.:.|...
Mouse   369 QSQSSSKDVTKVSASSVTYPAEVQNSSSEQKRSEVTKR---LSDERDPGTTSARESIISTQLSPT 430

  Fly   383 LNAAIA--------------------MEGQTALSFAPDDPIYKAAQYILDYIISG---------L 418
            .||.::                    :..:::.:..|..|.....|.|..:.::.         |
Mouse   431 RNAKLSQISLDHQKEEKEMKSTWNGGLSKKSSYAGEPGSPTDAPPQGIFSFPVNSNTQQNLQHCL 495

  Fly   419 NDDLSEDECALQVLISRIKDFVCDAKKYVHYKA------------YQII---------------- 455
            .|.::.:|  |..:|..|..:|......:.|.|            |.:.
Mouse   496 KDKVTSEE--LNSIIQNIMTWVVATVTSILYPAITKYEERVQNNTYPVTDDSDLSSDSSSFCSTC 558

  Fly   456 --GFA-RDHKA---------------MEVPPSMAKQPKNH---------------SRASHVSFSG 487
              ||. |::.|               ::.||:..|.|..|               |..|.|::..
Mouse   559 SEGFTYRNYTAKTLPVDPCTFASDMPIKKPPTPLKPPSAHVERTVIDQTYQRQGQSVPSQVNYQK 623

  Fly   488 VA-----STIGVGSYEIHPFVDVRPCSERRATPAGSLASLVVSQIGEQVIQDKVRLPHLNRNQIV 547
            .:     ..||....:.|....:..|:::.........||.:|.:.::..:...::.:|
Mouse   624 TSLDYQFPKIGSSKSDSHLLTSLETCTKKSKDATTETESLEISLLYDKKAKAMDQIKNL------ 682

  Fly   548 FIEHYLVKFKRDLLVGLDKLVFAAIQCHFENRMMEVREELLLLDRNYLFEQIARGILSYAVNPLN 612
                              |.||...:||.:.      |..|:|:.  :|::|... ||.|:..|:
Mouse   683 ------------------KNVFVNFKCHLKG------ETQLILES--IFQEIMSD-LSQAIPSLS 720

  Fly   613 YQSVL-------------KLAVSVQSCEIIWELQQTML------------------------KPG 640
              ||.             :|..:|..|.:..|:.:.||                        ||.
Mouse   721 --SVTAEVFVDQTETEREELLSNVDICSVASEIVENMLEKLESAVEKRCVQMFSQEDLSVDIKPS 783

  Fly   641 IDPRGQNHPVSCGTEQERETLA 662
            :...| ::..|..|:...|||:
Mouse   784 LSTSG-DYLSSVETKPSEETLS 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3345	NP_608509.1	None
Fsip2	NP_001357195.1	DUF5401	<136..>309	CDD:340095	49/223 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..292		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..336		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1450..1470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2552..2593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2697..2729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3180..3268
		FSIP2	4045..>4588	CDD:318078
		FSIP2	4377..>4923	CDD:318078
		FSIP2	4902..>5433	CDD:318078
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5487..5663
		Atrophin-1	<5503..>5649	CDD:335243
		DUF4775	5622..6041	CDD:318258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5717..5738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5821..5876
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5941..5994
		FSIP2	5996..6860	CDD:318078
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6971..6993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CNP8
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42466
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840