DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17075 and Zdhhc2

DIOPT Version :10

Sequence 1:NP_608508.1 Gene:CG17075 / 33191 FlyBaseID:FBgn0031239 Length:968 Species:Drosophila melanogaster
Sequence 2:NP_848482.1 Gene:Zdhhc2 / 70546 MGIID:1923452 Length:366 Species:Mus musculus


Alignment Length:356 Identity:77/356 - (21%)
Similarity:130/356 - (36%) Gaps:115/356 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 SNIADVQHRKGRRLHGLQLPLHPLQIFGW---------LVLLLFGVASYWVLIPAFHARIQGPLY 145
            |....|:.|..|.|:.:.:....| :.||         .::.:..:....|.:.|:|.       
Mouse     4 SGSGGVRRRCRRVLYWIPVVFISL-LLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHL------- 60

  Fly   146 GLITGLYLVHIASHLTALLTDP-----------ADKELRR-----------VHRNDRIVPEFDRS 188
                 |:.:.:.|:...:.|.|           |:|||..           :.|..:.:|.:.|:
Mouse    61 -----LFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRT 120

  Fly   189 KHSHVIENGRCHLCNIRTSSNRTKHCSVCNKCVGKFDHHCKWLNHCIGSRNYVAFLMCVVSAVVA 253
            ....:....||.|    ...:|..|||||:||:.|.||||.|:|:|:|..||..||:.:..:::.
Mouse   121 MSGAIRYCDRCQL----IKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLY 181

  Fly   254 TLVIVAAVVAQIVFYYIQ--PD--------WLSF----------------YWCPTESSHTIES-- 290
            .|.|.|..:...:.::..  ||        :|.|                .|..:::..|:|:  
Mouse   182 CLFIAATDLQYFIRFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFR 246

  Fly   291 -------GDFINITLSLSNGTMMLIEQHTSEEDVHQEMWDEEQANMTISTLPTLLENFTAIIEAS 348
                   .|....:|..|             :::.|...||::..:    ||..          |
Mouse   247 NPVFRHGTDKNGFSLGFS-------------KNMRQVFGDEKKYWL----LPVF----------S 284

  Fly   349 ATRPGIS-PT---NHTETQPVVTGIGLNETI 375
            :...|.| ||   |....|| .|..|||.|:
Mouse   285 SQGDGCSFPTCLVNQDPEQP-STPAGLNSTV 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17075NP_608508.1 DHHC 199..>282 CDD:396215 31/108 (29%)
Zdhhc2NP_848482.1 DHHC 19..301 CDD:418707 65/325 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 297..366 8/19 (42%)
Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269|PubMed:21471008 298..366 8/18 (44%)
Non-canonical dileucine endocytic signal. /evidence=ECO:0000269|PubMed:28768144 334..335
NPxY-like endocytic signal. /evidence=ECO:0000269|PubMed:28768144 357..360
Blue background indicates that the domain is not in the aligned region.

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