DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17075 and ZDHHC8

DIOPT Version :9

Sequence 1:	NP_001245821.1	Gene:	CG17075 / 33191	FlyBaseID:	FBgn0031239	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_001171953.1	Gene:	ZDHHC8 / 29801	HGNCID:	18474	Length:	778	Species:	Homo sapiens

Alignment Length:	941	Identity:	177/941 - (18%)
Similarity:	262/941 - (27%)	Gaps:	403/941 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LLFGVAS-YWVLIPAFHARIQGPLYGLITG-LYLVHIASHLTALLTDPA---------DKELRRV 175
            ||.|.:: ::|....:..|...|...:..| ::|..:|:...|...||.         |||
Human    23 LLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLANFSMATFMDPGVFPRADEDEDKE---- 83

  Fly   176 HRNDRIVPEFDRSKHSHVIENG---------RCHLCNIRTSSNRTKHCSVCNKCVGKFDHHCKWL 231
                   .:|....:.:|...|         .||...    ..|..|||||:.||..|||||.|:
Human    84 -------DDFRAPLYKNVDVRGIQVRMKWCATCHFYR----PPRCSHCSVCDNCVEDFDHHCPWV 137

  Fly   232 NHCIGSRNYVAFLMCVVSAVVATLVIVAAVVAQIVFYYIQPDWLSFYWCPTESSHTIESGDFINI 296
            |:|||.|||..|.:.::|       :.|.:|..:.|
Human   138 NNCIGRRNYRYFFLFLLS-------LSAHMVGVVAF----------------------------- 166

  Fly   297 TLSLSNGTMMLIEQHTSEEDVHQEMWDEEQANMTISTLPTLLENFTAIIEASATRPGISPTNHTE 361
                  |.:.::.        |.|                                |:...:.|.
Human   167 ------GLVYVLN--------HAE--------------------------------GLGAAHTTI 185

  Fly   362 TQPVVTGIGLNETIFMFLLGVLGLLAAVSAGLLLHLCFFHIYISFLGLTTYEYIRNHRQAQDAKT 426
            |..|:...||      |.:.|:||..            ||:.:...|.||.|.:....:.
Human   186 TMAVMCVAGL------FFIPVIGLTG------------FHVVLVTRGRTTNEQVTGKFRG----- 227

  Fly   427 KQLLEGAPGVRAPKNGNVHFSASLPEPHNPSKSLPGGQQLYCCSSAPHPSQHSQESVGQTEQSLR 491
                    ||.....|                         ||.:..|
Human   228 --------GVNPFTRG-------------------------CCGNVEH----------------- 242

  Fly   492 LHCCASSREFHQSGQAIYVCSLLEEAVPQIQVEPDTLS-SFHCCSSFAASSLQRRV--------- 546
                             .:||.|   .|:..|||..|. :......|....|..|.
Human   243 -----------------VLCSPL---APRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSD 287

  Fly   547 ---------SLAKGSL--ISAEPRHLRP-------------------------ATYLQYTEQCTL 575
                     |.:||||  :..:|..|.|                         |..:|.|...|.
Human   288 NGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPRPGSAESALSVQRTSPPTP 352

  Fly   576 CTFRLRRG---------SGPGTGSSGAVSSAGGSSSTRTLTSQTGGSSASATAAGNISKHQRWRR 631
            ..::.|..         .|||....|..|...|..|.|:| ......|......|....|
Human   353 AMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSL-DFVSEPSLDLPDYGPGGLH----- 411

  Fly   632 KWNCCAAVPDSPDLP-----NDLLAALTFRESEEAAAAAKLNAQELPIQFIRTLNGGLDQELPLK 691
                 ||.|.||.|.     :..|.:|:.:      |:::.....:.:|             ||:
Human   412 -----AAYPPSPPLSASDAFSGALRSLSLK------ASSRRGGDHVALQ-------------PLR 452

  Fly   692 ATTATPTPPRSSRLRYMLRLLGRYRRPR----------CRHGAHHGIAAKEHQNIGGSAIKQNQI 746
            :....|||.||        :...:..|.          ...|:..|.|...|..:|.:......:
Human   453 SEGGPPTPHRS--------IFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYL 509

  Fly   747 RPLQLQAAGRGYANSTATPTPPASSPSRSSLESSDLSTSTSPSCGKKELMLLPTSVIRDDSVTTY 811
            .|             .||..||...|           .|.||..|.:
Human   510 HP-------------GATGDPPRPLP-----------RSFSPVLGPR------------------ 532

  Fly   812 TLTLPPALPPPTRRKMNQTTQELAELAETLGFASNLQHSQHNSQTNSRT-LPSFGNVYRRQRRKH 875
                 |..|.|.|                   ..||          ||| :.|......|:.|:.
Human   533 -----PREPSPVR-------------------YDNL----------SRTIMASIQERKDREERER 563

  Fly   876 FLRTRSPTLSPIHESGLSNPTSPQPLRHHHQNLANSNSNPAKAMSSP---MLNRNSGSANSSALL 937
            .||:::.:|  ..:||:.:..|...|: ....|:.....||....|.   :.....|.|.:.||.
Human   564 LLRSQADSL--FGDSGVYDAPSSYSLQ-QASVLSEGPRGPALRYGSRDDLVAGPGFGGARNPALQ 625

  Fly   938 VQNLCSLAGETLR-NSASNSSLQSLSSNSSS 967
            . :|.||:....| ...|:||||:..::|::
Human   626 T-SLSSLSSSVSRAPRTSSSSLQADQASSNA 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17075	NP_001245821.1	zf-DHHC	199..>282	CDD:279823	28/82 (34%)
ZDHHC8	NP_001171953.1	DHHC	99..224	CDD:366691	47/228 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..352		11/58 (19%)
		PHA03247	<333..771	CDD:223021	87/441 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..540		13/77 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810