DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17075 and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_001245821.1	Gene:	CG17075 / 33191	FlyBaseID:	FBgn0031239	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	645	Identity:	175/645 - (27%)
Similarity:	246/645 - (38%)	Gaps:	219/645 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SHSESPAKGVVTPVRKPHSLGSEDSPENIIPGEQAETNKKPLHLCRLSQLVSYQSNIADVQHRKG 100
            |:..:|.|.|.|...:|    |..|||                                :|.::.
Human    11 SNKTAPEKSVWTAPAQP----SGPSPE--------------------------------LQGQRS 39

  Fly   101 RRLHGLQLPLHPLQIFGWLVLLLFGVASYWVLIPAFHARIQGPLYGLITGLYLVHIASHLTALLT 165
            || :|...|.|||||..||:.|.|.|..:.:|:|..........|..:..::..|:..||||:..
Human    40 RR-NGWSWPPHPLQIVAWLLYLFFAVIGFGILVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSI 103

  Fly   166 DPADKELRRVHRNDRI----VPEFDRSKHSHVIENGRCHLCNIRTSSNRTKHCSVCNKCVGKFDH 226
            ||||..:|     |:.    :|.|:||:|:||||:..|:|||:..|: |:||||.|||||..|||
Human   104 DPADANVR-----DKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSA-RSKHCSACNKCVCGFDH 162

  Fly   227 HCKWLNHCIGSRNYVAFLMCVVSAVVATLVIVAAVVAQIVFYYIQPDWLSFYWCPTESSHTIESG 291
            ||||||:|:|.|||..||..|.||::..|::|  :||..||       :.|
Human   163 HCKWLNNCVGERNYRLFLHSVASALLGVLLLV--LVATYVF-------VEF-------------- 204

  Fly   292 DFINITLSLSNGTMMLIEQHTSEEDVHQEMWDEEQANMTISTLPTLLENFTAIIEASATRPGISP 356
             |:|.....:|....:::.||       ::|                  |..:           |
Human   205 -FVNPMRLRTNRHFEVLKNHT-------DVW------------------FVFL-----------P 232

  Fly   357 TNHTETQ-PVVTGIGLNETIFMFLLGVLGLLAAVSAGLLLHLCFFHIYISFLGLTTYEYIRNHRQ 420
            ....||| |.:..:..       ||.:||||   |..||.||..||||:.:..|||||||..||.
Human   233 AAPVETQAPAILALAA-------LLILLGLL---STALLGHLLCFHIYLMWHKLTTYEYIVQHRP 287

  Fly   421 AQDAK-TKQLLEGAPGVRAPKNGNVH--------FSASLPEPHNPSKSLPGG-QQLYCCSSAPHP 475
            .|:|| ..:.||..|    ||...:.        |....|||  |.::.|.. ...:...::|.|
Human   288 PQEAKGVHRELESCP----PKMRPIQEMEFYMRTFRHMRPEP--PGQAGPAAVNAKHSRPASPDP 346

  Fly   476 SQHSQESVGQTEQSLRLHCCASSREFHQSGQAIYVCSLLEEAVPQIQVEPDTLSSFHCCSSF--- 537
            :...::..|                                  |.:|||.|........|..
Human   347 TPGRRDCAG----------------------------------PPVQVEWDRKKPLPWRSPLLLL 377

  Fly   538 ------AASSLQRRVSLAKGSLISAEPRHLRPATYLQYTEQCTLCTFRL-RRGSGPGTGSSGAVS 595
                  |...|.|:  ..:|:.|..|  .|||               |: |||.||
Human   378 AMWGPQAPPCLCRK--RGRGACIKCE--RLRP---------------RIRRRGLGP--------- 414

  Fly   596 SAGGSSSTRTLTSQTGGSSASATAAGNISKHQ------RWRRK------WNCCAAVPDSP 643
             ...:.:.|.:.......:..|..|....:.|      :|||:      |....|..|||
Human   415 -PAAAPARRRIPRTPALCTPLALPAPTTRRRQSPWTRFQWRRRAWAAPLWPPRGAGADSP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17075	NP_001245821.1	zf-DHHC	199..>282	CDD:279823	41/82 (50%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		115/372 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		11/65 (17%)
		zf-DHHC	129..284	CDD:307600	79/225 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358		8/69 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485		5/12 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5201
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4503
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003723
OrthoInspector	1	1.000	-	-		otm41802
orthoMCL	1	0.900	-	-		OOG6_102853
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4313
SonicParanoid	1	1.000	-	-		X1257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.650