Protein Alignment CG17075 and ZDHHC5

DIOPT Version :10

• Sequence 1: NP_608508.1
• Gene: CG17075 / 33191
• FlyBaseID: FBgn0031239
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_056272.2
• Gene: ZDHHC5 / 25921
• HGNCID: 18472
• Length: 715
• Species: Homo sapiens
• Alignment Length: 794
• Identity: 172/794 - (21%)
• Similarity: 265/794 - (33%)
• Gaps: 248/794 - (31%)

  Fly   143 PLYGLITGLYLVHIASHLTALLTDPA---------DKELRRVHRNDRIVPEFDRSKHSHV-IENG 197
            |:|..|  ::|..:|:...|...||.         |||      :|...|.:...:...: :...
Human    48 PIYNAI--MFLFVLANFSMATFMDPGIFPRAEEDEDKE------DDFRAPLYKTVEIKGIQVRMK 104

  Fly   198 RCHLCNIRTSSNRTKHCSVCNKCVGKFDHHCKWLNHCIGSRNYVAFLMCVVSAVVATLVIVAAVV 262
            .|..|...... |..|||||:.||.:|||||.|:|:|||.|||..|.:.::| :.|.::.|....
Human   105 WCATCRFYRPP-RCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLS-LTAHIMGVFGFG 167

  Fly   263 AQIVFYYIQPDWLSFYWCPTESSHTIESGDFINITLSLSNGTMMLIEQ-HTSEEDVHQEM----- 321
            ...|.|:|:.  ||........:....:|.|......|:...::|:.: .|:.|.|..:.
Human   168 LLYVLYHIEE--LSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVN 230

  Fly   322 ------WDEEQANMTISTLPTLL----ENFTAIIEASATRPGISPTNHTETQPVVTGI--GLNET 374
                  .:.....:..|..|..|    :..|.:|.....||.:|....| .:.:..||  .|..|
Human   231 PFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQIT-VKIMDNGIQGELRRT 294

  Fly   375 IFMFLLGVLGLLAAVSA----------------GLLLHLCFFHIYISFLGLTTYEYIRNHRQAQD 423
            ...   |.|.:..:.||                ||..|          |||.|.|  .:...|:|
Human   295 KSK---GSLEITESQSADAEPPPPPKPDLSRYTGLRTH----------LGLATNE--DSSLLAKD 344

  Fly   424 A-KTKQLLEGAPGVRAPKNGNVHFSASLPEPHNPSKSLPGGQQL----YCCSSAPHPSQHSQESV 483
            : .|..:.:..||..:.       |.|...||:.|..|..|..|    ....|:.|||..|:.|
Human   345 SPPTPTMYKYRPGYSSS-------STSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPS- 401

  Fly   484 GQTEQSLRLHCCASSREFHQSGQAIYVCSLLEEAVPQIQVEPDTLSSFHC--CSSFAASSLQRRV 546
                                          ||   |:....|....|||.  .||.:.||
Human   402 ------------------------------LE---PESFRSPTFGKSFHFDPLSSGSRSS----- 428

  Fly   547 SLAKGSLISAEPRHLRPATYLQYTEQCTLCTFRLRRGSGPGTGSSGAVSSAG-GSSSTRTLTSQT 610
                 ||.||:                         |:|...|...::.|.| .|:|.::|.:||
Human   429 -----SLKSAQ-------------------------GTGFELGQLQSIRSEGTTSTSYKSLANQT 463

  Fly   611 GGSSASATAAGNISKHQRWRRKWNCCAAVPDSPDLPNDLLAALTFRESEEAAAAAKLNAQELPIQ 675
            ...|.|                ::......||||.           ||.:|..     ..:.|:.
Human   464 RNGSLS----------------YDSLLTPSDSPDF-----------ESVQAGP-----EPDPPLG 496

  Fly   676 FIRT-LNGGLDQE---------LPLKATTATPTPPRSSRLRYMLRLLGRYRRPRCRHGAHHGIAA 730
            :... |:..|.|:         :|...|...|:|.|...|                  :.|.:|:
Human   497 YTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNL------------------SRHIVAS 543

  Fly   731 KEHQNIGGSAIKQNQIRPLQLQAAGRGYANSTATP----TPPASSPS----RSSLESSDLSTSTS 787
            .:.:.   ..::|:...|.:.:..|.|.:...:||    .|..||.|    ||.|..:.|.....
Human   544 LQERE---KLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPLGRPAV 605

  Fly   788 PSCGKKELML---------LPTSVIRDDSVT------------TYTLTLPPALPPPTRRKMNQTT 831
            |..||.:.:.         .||:.....|::            |..:.|.|.|.|....::..|.
Human   606 PRFGKPDGLRGRGVGSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTPKDEVQLKTTY 670

  Fly   832 QELAELAETLGFAS 845
            .:.....::||.||
Human   671 SKSNGQPKSLGSAS 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17075	NP_608508.1	DHHC	199..>282	CDD:396215	32/82 (39%)
ZDHHC5	NP_056272.2	DHHC	99..224	CDD:396215	39/128 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..715		109/540 (20%)