DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17075 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_001245821.1	Gene:	CG17075 / 33191	FlyBaseID:	FBgn0031239	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_659564.3	Gene:	Zdhhc2 / 246326	RGDID:	628681	Length:	366	Species:	Rattus norvegicus

Alignment Length:	212	Identity:	50/212 - (23%)
Similarity:	88/212 - (41%)	Gaps:	50/212 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VQHRKGRRLHGLQLPLHPLQIFGW---------LVLLLFGVASYWVLIPAFHARIQGPLYGLITG 150
            |:.|..|.|:.:.:....| :.||         .::.:..:....|.:.|:|.
  Rat     9 VRRRCRRVLYWIPVVFISL-LLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHL------------ 60

  Fly   151 LYLVHIASHLTALLTDP-----------ADKELRR-----------VHRNDRIVPEFDRSKHSHV 193
            |:.:.:.|:...:.|.|           |:|||..           :.|..:.:|.:.|:....:
  Rat    61 LFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAI 125

  Fly   194 IENGRCHLCNIRTSSNRTKHCSVCNKCVGKFDHHCKWLNHCIGSRNYVAFLMCVVSAVVATLVIV 258
            ....||.|    ...:|..|||||:||:.|.||||.|:|:|:|..||..||:.:..:::..|.|.
  Rat   126 RYCDRCRL----IKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIA 186

  Fly   259 AAVVAQIVFYYIQ--PD 273
            |..:...:.::..  ||
  Rat   187 ATDLQYFIRFWTNGLPD 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17075	NP_001245821.1	zf-DHHC	199..>282	CDD:279823	28/77 (36%)
Zdhhc2	NP_659564.3	DHHC	19..301	CDD:418707	46/202 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..366
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000250\|UniProtKB:P59267	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000250\|UniProtKB:P59267	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000250\|UniProtKB:P59267	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900