Protein Alignment kis and MOT1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_015243.1
• Gene: MOT1 / 856023
• SGDID: S000006003
• Length: 1867
• Species: Saccharomyces cerevisiae
• Alignment Length: 1359
• Identity: 308/1359 - (22%)
• Similarity: 495/1359 - (36%)
• Gaps: 466/1359 - (34%)

  Fly  1588 VGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYIN------TGDEDSMV 1646
            |||:..|..::....|:.|.......||:|.||....::.:....|..:||      .||...:.
Yeast   647 VGEKGKNYAMESQYILKPSQHYQLHPEKKRSISETTTDSDIPIPKNNEHINIDAPMIAGDITLLG 711

  Fly  1647 VQLVLAMR-MGKR--------------------------ELILDKPK---------------EKA 1669
            :.::|..| ||.:                          ||....|:               :|.
Yeast   712 LDVILNTRIMGAKAFALTLSMFQDSTLQSFFTNVLVRCLELPFSTPRMLAGIIVSQFCSSWLQKH 776

  Fly  1670 PE-------------PKQDEEKSELDE-------------------------------------- 1683
            ||             |..:::....||
Yeast   777 PEGEKLPSFVSEIFSPVMNKQLLNRDEFPVFRELVPSLKALRTQCQSLLATFVDVGMLPQYKLPN 841

  Fly  1684 ------------------ATTDKPEG---DEKFKTEGES-----KKDLTDSEETKLESSAMEVDS 1722
                              .|.:|..|   |:.||:...|     ||.|.||:...|    |.::|
Yeast   842 VAIVVQGETEAGPHAFGVETAEKVYGEYYDKMFKSMNNSYKLLAKKPLEDSKHRVL----MAINS 902

  Fly  1723 KEESEP-------------------------------DDSKKSDEDNK----------------- 1739
            .:||..                               .||.|.:.:.|
Yeast   903 AKESAKLRTGSILANYASSILLFDGLPLKLNPIIRSLMDSVKEERNEKLQTMAGESVVHLIQQLL 967

  Fly  1740 DKDKMEVDDEVGKS-------DKESKPE-----EQSETVKT---EENSKAIEEDKSSTVLTADHA 1789
            :.:|:.|..::.|:       |....|:     |..|.:.|   |.||.|.::|    :..|..:
Yeast   968 ENNKVNVSGKIVKNLCGFLCVDTSEVPDFSVNAEYKEKILTLIKESNSIAAQDD----INLAKMS 1028

  Fly  1790 KEPE-------------------TVLEKM---------EVDEKANDDQSAVSKAEGSDEKSTDDS 1826
            :|.:                   ::|:|:         .:.:..|::.|.|...:|  :|..|..
Yeast  1029 EEAQLKRKGGLITLKILFEVLGPSILQKLPQLRSILFDSLSDHENEEASKVDNEQG--QKIVDSF 1091

  Fly  1827 NPEEATTEKNKESLEIEGEKERVK------EGEESVKKENDEKTEADMENKPEPVFIDVEEYFVK 1885
            ....|......:||.......|..      ....||.:.:..:|.||:.....   ::|..|.::
Yeast  1092 GVLRALFPFMSDSLRSSEVFTRFPVLLTFLRSNLSVFRYSAARTFADLAKISS---VEVMAYTIR 1153

  Fly  1886 YRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSV 1950
                           |:|                  ..:|...::.|   .|..||:...|.:|:
Yeast  1154 ---------------EIL------------------PLMNSAGSLSD---RQGSTELIYHLSLSM 1182

  Fly  1951 HTD----------------ETSGE-------TTKHYLVKW----------KSLPYEDCTWELEED 1982
            .||                ..|.|       ||...::|.          |.||.|   .....:
Yeast  1183 ETDVLPYVIFLIVPLLGRMSDSNEDVRNLATTTFASIIKLVPLEAGIADPKGLPEE---LVASRE 1244

  Fly  1983 VDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPV-YKGGNSLRPYQLEGLNWLKF-SWY 2045
            .:.|.|:|.:.          .||.:|.        |.|: .|.  :||.||.:|:|||.| :.|
Yeast  1245 RERDFIQQMMD----------PSKAKPF--------KLPIAIKA--TLRKYQQDGVNWLAFLNKY 1289

  Fly  2046 NTHNCILADEMGLGKTIQSLTFV--------------HSVYEYGIRGPFLVIAPLSTIPNWQREF 2096
            :.|. ||.|:||||||:|::..:              .||....:  |.|:|.|.|...:|:.||
Yeast  1290 HLHG-ILCDDMGLGKTLQTICIIASDQYLRKEDYEKTRSVESRAL--PSLIICPPSLTGHWENEF 1351

  Fly  2097 EGWTD-MNVVVYHGS----VTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLK 2156
            :.:.. :.||||.|.    :|.:..:.|.:                  :::|::::...|...|.
Yeast  1352 DQYAPFLKVVVYAGGPTVRLTLRPQLSDAD------------------IIVTSYDVARNDLAVLN 1398

  Fly  2157 AFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQE 2221
            ...:..||:||.|.:||...||.:.::::...||::|:|||:|||:.||:||.:||.|....:::
Yeast  1399 KTEYNYCVLDEGHIIKNSQSKLAKAVKEITANHRLILTGTPIQNNVLELWSLFDFLMPGFLGTEK 1463

  Fly  2222 EFMSEF------------GSLRTEEEVNKLQALLK---PMMLRRLKDDVEKSLAPKEETIIE--- 2268
            .|...|            .|...|..|..|:||.|   |.||||||:||...|.||   ||:
Yeast  1464 MFQERFAKPIAASRNSKTSSKEQEAGVLALEALHKQVLPFMLRRLKEDVLSDLPPK---IIQDYY 1525

  Fly  2269 VELTNIQKKYYRGILEQNFSFLKKGTTSANI----PNLMNTMMELRKCCIHPYLLNGAEE----Q 2325
            .||.::||:.|....::..:.::|...::.|    .::...:..:||.|.||.|:.....    |
Yeast  1526 CELGDLQKQLYMDFTKKQKNVVEKDIENSEIADGKQHIFQALQYMRKLCNHPALVLSPNHPQLAQ 1590

  Fly  2326 IQYDFKSQHGEDPESYYKNLILSAGKMVL---------IDKLLPKLKA------------NGHRV 2369
            :| |:..|.|.|.........|||.:.:|         |||     ||            :.||.
Yeast  1591 VQ-DYLKQTGLDLHDIINAPKLSALRTLLFECGIGEEDIDK-----KASQDQNFPIQNVISQHRA 1649

  Fly  2370 LIFSQMVRCLDILEDYLVYRKY----PFERIDGRIRGNLRQEAIDRYSK-PGSDRFVFLLCTKAG 2429
            |||.|:...||::|:.| ::||    .:.|:||.|....||:.:.:::: |..|  ..||.||.|
Yeast  1650 LIFCQLKDMLDMVENDL-FKKYMPSVTYMRLDGSIDPRDRQKVVRKFNEDPSID--CLLLTTKVG 1711

  Fly  2430 GLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGL 2494
            |||:|||.|||||..:.||||.|||||..|.|||||:|:|.:||::.:.|.|.::......|:.:
Yeast  1712 GLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNI 1776

  Fly  2495 DKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVIT 2559
            ...|:...|:         .|:..:...||.      :.|.||...:..||..:...:....:..
Yeast  1777 ASTVVNQQNS---------GLASMDTHQLLD------LFDPDNVTSQDNEEKNNGDSQAAKGMED 1826

  Fly  2560 MESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPR 2618
            :.:|.|.|         |...:...:..:.|         ||...|.:...|..:...|
Yeast  1827 IANETGLT---------GKAKEALGELKELW---------DPSQYEEEYNLDTFIKTLR 1867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	86/556 (15%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	9/66 (14%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	19/90 (21%)
		PLN03142	2029..>2606	CDD:215601	192/648 (30%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
MOT1	NP_015243.1	HEAT repeat	360..385	CDD:293787
		HEAT repeat	406..438	CDD:293787
		HEAT repeat	449..481	CDD:293787
		HEAT repeat	490..519	CDD:293787
		HEAT repeat	543..572	CDD:293787
		DUF3535	611..1063	CDD:463447	67/423 (16%)
		HepA	<1258..1781	CDD:440319	180/565 (32%)