Protein Alignment kis and SNF2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_014933.3
• Gene: SNF2 / 854465
• SGDID: S000005816
• Length: 1703
• Species: Saccharomyces cerevisiae
• Alignment Length: 1773
• Identity: 437/1773 - (24%)
• Similarity: 731/1773 - (41%)
• Gaps: 417/1773 - (23%)

  Fly  1344 AVKKRAGASKRRKQYGEDGAEQ-----TGEGSEVEDNKP----------LVPKAGSADGEAETTS 1393
            |.|:|.....:|:|.|..|::|     :.:.:|:.:|..          |.|.......|..:||
Yeast    47 AAKQRQELQMQRQQQGISGSQQNIVPNSSDQAELPNNASSHISASASPHLAPNMQLNGNETFSTS 111

  Fly  1394 GGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSR 1458
            .     .:||    |..:::|..||...........:|.|:  :|.:.:.||         |.:.
Yeast   112 A-----HQSP----IMQTQMPLNSNGGNNMLPQRQSSVGSL--NATNFSPTP---------ANNG 156

  Fly  1459 RNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGED-DTLDRTPPPSPPPDSEMDSNKRRS 1522
            .|| :|:..::..|..:|:...|:.   :.|.:.|.:.:| :.:..:...||.|........:..
Yeast   157 ENA-AEKPDNSNHNNLNLNNSELQP---QNRSLQEHNIQDSNVMPGSQINSPMPQQAQMQQAQFQ 217

  Fly  1523 SRNTQRKKYIDDV--------------MLRFSDDENSLLVA------------------------ 1549
            ::..|:.:.....              |..|:.:::.||.|
Yeast   218 AQQAQQAQQAQQAQQAQARLQQGRRLPMTMFTAEQSELLKAQITSLKCLVNRKPIPFEFQAVIQK 282

  Fly  1550 ---------------SPVKKDKKPS--ANASNSNAGSDVEK-----------TEPQSGAEGDAAQ 1586
                           |...:.::|:  .|.||.|.|::.::           |:..||...:|..
Yeast   283 SINHPPDFKRMLLSLSEFARRRQPTDQNNQSNLNGGNNTQQPGTNSHYNNTNTDNVSGLTRNAPL 347

  Fly  1587 EVGEEK---------------SNLPLDESSQLEAS---SSTSAVAEKERQISTDAANAAMSSKPN 1633
            :..:|.               .|..||::||..:.   :.|.:..|:...||..|..|..|:|
Yeast   348 DSKDENFASVSPAGPSSVHNAKNGTLDKNSQTVSGTPITQTESKKEENETISNVAKTAPNSNK-- 410

  Fly  1634 YVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEP---KQDEEKSELDEATTDKPE-GDEK 1694
                 |..|.:                  :.||.:.|.|   .||:.|..:.....|.|: ..:.
Yeast   411 -----THTEQN------------------NPPKPQKPVPLNVLQDQYKEGIKVVDIDDPDMMVDS 452

  Fly  1695 FKTEGESKKD------LTDSEETK--LESSAMEVDSKEESEPDDSKKSDEDNKDK------DKME 1745
            |.....|..:      |.:|:..|  :|...:.|.....:..|..:.....|.|.      ||:
Yeast   453 FTMPNISHSNIDYQTLLANSDHAKFTIEPGVLPVGIDTHTATDIYQTLIALNLDTTVNDCLDKL- 516

  Fly  1746 VDDEVGKSDKES------------------------KPEEQSETVKTEEN--SKAIEEDKSSTVL 1784
            ::||..:|.:|:                        :..:.|....|..|  ||....:....:|
Yeast   517 LNDECTESTRENALYDYYALQLLPLQKAVRGHVLQFEWHQNSLLTNTHPNFLSKIRNINVQDALL 581

  Fly  1785 TADHAKEPETV-LEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKER 1848
            |....|..|.: ||:.:.:        ||::.:..::.:.:..|..:  .:|||          |
Yeast   582 TNQLYKNHELLKLERKKTE--------AVARLKSMNKSAINQYNRRQ--DKKNK----------R 626

  Fly  1849 VKEGEESV----KKENDEKTEADMENKP--EPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDR 1907
            :|.|...:    ..|.||:..|:.:.|.  :.:..:.||.::|..:        :|:      |.
Yeast   627 LKFGHRLIATHTNLERDEQKRAEKKAKERLQALKANDEEAYIKLLD--------QTK------DT 677

  Fly  1908 RVAAKIRRFQQKQSQQLNIF-----ENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLV-K 1966
            |:...:|        |.|.|     ..::|:   |.:|:  .::|.  |..|.|.|.....:| |
Yeast   678 RITHLLR--------QTNAFLDSLTRAVKDQ---QKYTK--EMIDS--HIKEASEEVDDLSMVPK 727

  Fly  1967 WKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRP 2031
            .|...|:|       |.||..::.|...::|.:                .::|.|....|.:|:.
Yeast   728 MKDEEYDD-------DDDNSNVDYYNVAHRIKE----------------DIKKQPSILVGGTLKD 769

  Fly  2032 YQLEGLNWLKFSWYNTH-NCILADEMGLGKTIQSLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQR 2094
            ||::||.|: .|.:|.| |.|||||||||||||:::.:..:||. .||||:|||.||||:.||..
Yeast   770 YQIKGLQWM-VSLFNNHLNGILADEMGLGKTIQTISLLTYLYEMKNIRGPYLVIVPLSTLSNWSS 833

  Fly  2095 EFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAF 2158
            ||..|. .:..:.:.||...::..|     .|..:|       :|:|::||||.|:.:...|...
Yeast   834 EFAKWAPTLRTISFKGSPNERKAKQ-----AKIRAG-------EFDVVLTTFEYIIKERALLSKV 886

  Fly  2159 NWRLCVIDEAHRLKNRNCKLLEGLR-QLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEE 2222
            .|...:|||.||:||...||...|. ..:.::|::|:|||||||:.||::||||:.|..|:|.:.
Yeast   887 KWVHMIIDEGHRMKNAQSKLSLTLNTHYHADYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKS 951

  Fly  2223 FMSEFGS------------LRTEEE---VNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELT 2272
            |...|.:            |..||.   :.:|..:|:|.:|||||.||||.|..|.|.:::.:::
Yeast   952 FDEWFNTPFANTGGQDKIELSEEETLLVIRRLHKVLRPFLLRRLKKDVEKELPDKVEKVVKCKMS 1016

  Fly  2273 NIQKKYYRGILEQNFSFL--KKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHG 2335
            .:|:..|:.:|:....|:  :.......:....|.:|:|:|.|.||::....|:||.   .::..
Yeast  1017 ALQQIMYQQMLKYRRLFIGDQNNKKMVGLRGFNNQIMQLKKICNHPFVFEEVEDQIN---PTRET 1078

  Fly  2336 EDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRI 2400
            .|      ::...|||..|:|::||||||.|||||||.||.:.:||:||:|.|....:.|:||..
Yeast  1079 ND------DIWRVAGKFELLDRILPKLKATGHRVLIFFQMTQIMDIMEDFLRYINIKYLRLDGHT 1137

  Fly  2401 RGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQ 2465
            :.:.|.|.:..::.|.|:...|:|.|:|||||:||..||||||:|:||||..|||||.|.|||||
Yeast  1138 KSDERSELLRLFNAPDSEYLCFILSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQ 1202

  Fly  2466 RKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKK---------EIE 2521
            :..|:|.||:..|:.|..:.::|..||.:|..|:|:    |..|  ||..|::         :.|
Yeast  1203 KNEVRILRLITTNSVEEVILERAYKKLDIDGKVIQA----GKFD--NKSTSEEQEALLRSLLDAE 1261

  Fly  2522 DLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQ---VITMESEKGSTFSKASFAASG--NRSD 2581
            :..:|.....|.:::...|    .:|:.||.|..:   |:|...|..|...:.....|.  .:|:
Yeast  1262 EERRKKRESGVEEEEELKD----SEINEILARNDEEMAVLTRMDEDRSKKEEELGVKSRLLEKSE 1322

  Fly  2582 ITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEES---SNEN 2643
            :    ||.:::     ||..: .:|:|:|...:...|...:.|...:.|.|   |||.   ..|.
Yeast  1323 L----PDIYSR-----DIGAE-LKREESESAAVYNGRGARERKTATYNDNM---SEEQWLRQFEV 1374

  Fly  2644 SDEEGGIGLRSRRRKEKRDRAREKKGNDEY----IPRERDALAALGLEEIQYGNWAKSECFKVEK 2704
            ||:|.......::|.:|.|::....||.|.    |..:.|...   :..|...:.|.::....:.
Yeast  1375 SDDEKNDKQARKQRTKKEDKSEAIDGNGEIKGENIDADNDGPR---INNISAEDRADTDLAMNDD 1436

  Fly  2705 GLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEV 2769
            ..|       |:..:.|:.:...:.|.:|               |.|..:....:....|.|...
Yeast  1437 DFL-------SKKRKAGRPRGRPKKVKLE---------------GSENSEPPALESSPVTGDNSP 1479

  Fly  2770 QKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGI 2834
            .:...|       :|:.|..||::.:|...||...|...|...|      :........|...|:
Yeast  1480 SEDFMD-------IPKPRTAGKTSVKSARTSTRGRGRGRGRGRG------RGRGRGRPPKARNGL 1531

  Fly  2835 NASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLR--VRMLY-----YIQHE 2892
            :.....||.||..|......|:..|...:... |:...||..:.:.|.  .:.||     .|::.
Yeast  1532 DYVRTPAAATSPIDIREKVAKQALDLYHFALN-YENEAGRKLSDIFLSKPSKALYPDYYMIIKYP 1595

  Fly  2893 VIGDFVQQIKDNTPISEL 2910
            |..|.:     ||.|..|
Yeast  1596 VAFDNI-----NTHIETL 1608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	36/171 (21%)
		PTZ00121	<1419..1923	CDD:173412	108/639 (17%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	13/72 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	16/58 (28%)
		PLN03142	2029..>2606	CDD:215601	218/611 (36%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
SNF2	NP_014933.3	QLQ	248..281	CDD:462622	4/32 (13%)
		HSA	<617..656	CDD:462194	12/50 (24%)
		PLN03142	650..>1297	CDD:215601	240/730 (33%)
		SnAC	1303..1369	CDD:464219	17/78 (22%)
		Bromo_SNF2	1550..1652	CDD:99950	15/65 (23%)