Protein Alignment kis and RAD26

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_012569.1
• Gene: RAD26 / 853492
• SGDID: S000003796
• Length: 1085
• Species: Saccharomyces cerevisiae
• Alignment Length: 1154
• Identity: 281/1154 - (24%)
• Similarity: 488/1154 - (42%)
• Gaps: 298/1154 - (25%)

  Fly  1676 EEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKD 1740
            |:|.:.|.|   |.|.:|..|..|.:....:..|| |:.:......:.:      |.:.:|...:
Yeast     2 EDKEQQDNA---KLENNESLKDLGVNVLSQSSLEE-KIANDVTNFSNLQ------SLQQEETRLE 56

  Fly  1741 KDKMEVDDEVGKSDKESKPEEQSETVKTEEN----SKAIEEDKSSTVLTADHAKEPETVLEKMEV 1801
            :.|..:...|.|.:..::....:..:..::|    .|.::.|....||     |:.:.:..:::
Yeast    57 RSKTALQRYVNKKNHLTRKLNNTTRISVKQNLRDQIKNLQSDDIERVL-----KDIDDIQSRIK- 115

  Fly  1802 DEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKER---VKEGE---------- 1853
            :.|...||.|.:|.                    :||.|:..||.|:   ::.|:
Yeast   116 ELKEQVDQGAENKG--------------------SKEGLQRPGETEKEFLIRTGKITAFGHKAGF 160

  Fly  1854 --ESVKKE---NDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKI 1913
              ::..:|   |||:.:.|.|...|.:   ||..               |:|:
Yeast   161 SLDTANREYAKNDEQKDEDFEMATEQM---VENL---------------TDED------------ 195

  Fly  1914 RRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWE 1978
                          :|:.|:.:.....|.:         |:...|.....|.:.:.|.:.....|
Yeast   196 --------------DNLSDQDYQMSGKESE---------DDEEEENDDKILKELEDLRFRGQPGE 237

  Fly  1979 LEEDVDNDKIEQYLRFNK-IPQRS----------EWKSKKRPHPEL-WKKLE---KTP--VYKGG 2026
            .::  |.|::....|..| :.|||          ||   :||||.: ..||.   |.|  :|
Yeast   238 AKD--DGDELYYQERLKKWVKQRSCGSQRSSDLPEW---RRPHPNIPDAKLNSQFKIPGEIY--- 294

  Fly  2027 NSLRPYQLEGLNWLKFSWYNTHNC--ILADEMGLGKTIQSLTFVHSVYEYG-IRGPFLVIAPLST 2088
            :.|..||...:.|| :..|. .||  |:.||||||||||.:.|:.:::..| :.||.|::.|.:.
Yeast   295 SLLFNYQKTCVQWL-YELYQ-QNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLTGPVLIVCPATV 357

  Fly  2089 IPNWQREFE-GWTDMNVVVYH--GS-------------------VTSKQMIQDYE-YYYKTESGK 2130
            :..|..||: .|..:..|:.|  ||                   :.||.....|| :...|.:.|
Yeast   358 MKQWCNEFQHWWPPLRTVILHSMGSGMASDQKFKMDENDLENLIMNSKPSDFSYEDWKNSTRTKK 422

  Fly  2131 VLKEPIKFNVLI----TTFEMIVTDYMDLKAFN-------WRLCVIDEAHRLKNRNCKLLEGLRQ 2184
            .|:.....:.||    |...:::|.|:.|:..:       |:..|:||.|:::|.:.::....::
Yeast   423 ALESSYHLDKLIDKVVTDGHILITTYVGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKK 487

  Fly  2185 LNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF------GSLRTEEEVN------ 2237
            |...:|::|||||:|||::||:||.:|:.|.:..:...|..:|      |.......:.
Yeast   488 LKTHNRIILSGTPIQNNLTELWSLFDFIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYK 552

  Fly  2238 ---KLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQK-KYYRGILEQNFSFLKKGTTSAN 2298
               .|:.|:.|.:|||:|.||.|.|..|:|.::..:||..|: ||...:...:.:.::.|..
Yeast   553 CAVALRDLISPYLLRRVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKR--- 614

  Fly  2299 IPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLK 2363
              |::..:..|||.|.||.||:...::...|:     .||:        .:|||.::.:||....
Yeast   615 --NVLFGIDILRKICNHPDLLDRDTKRHNPDY-----GDPK--------RSGKMQVVKQLLLLWH 664

  Fly  2364 ANGHRVLIFSQMVRCLDILEDYLVYRKYP------FERIDG--RIRGNLRQEAIDRYSKPGSDRF 2420
            ..|::.|:|:|..:.|||||:: :..|.|      :.|:||  .|:|  ||..:||::....|
Yeast   665 KQGYKALLFTQSRQMLDILEEF-ISTKDPDLSHLNYLRMDGTTNIKG--RQSLVDRFNNESFD-- 724

  Fly  2421 VFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMF 2485
            ||||.|:.||||:|||.|:.:||:|.||||..|:||:.|..||||::.|.||||:...:.|.:::
Yeast   725 VFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAWRIGQKREVSIYRLMVGGSIEEKIY 789

  Fly  2486 DKASMKLGLDKAVLQSMNTQGSKDGNNKQLSK-KEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDS 2549
            .:...|..|...:|        .|...|:..| .|:.||...|.       :|.   :..|:::.
Yeast   790 HRQIFKQFLTNRIL--------TDPKQKRFFKIHELHDLFSLGG-------ENG---YSTEELNE 836

  Fly  2550 ILKRRTQVI-TMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETED-- 2611
            .:::.|:.: ..:||:...|.:....:..::.:      .|:....||        |..:|||
Yeast   837 EVQKHTENLKNSKSEESDDFEQLVNLSGVSKLE------SFYNGKEKK--------ENSKTEDDR 887

  Fly  2612 ----LVLSEPRRRTQIKRYGHEDVMELNS-EESSNENSDEEGGIGLRS----RRRKEKRDRARE- 2666
                |:..|....|.:   .|:.|:..:: ..|||..:.|...:.:.:    |:.::|..:..|
Yeast   888 LIEGLLGGESNLETVM---SHDSVVNSHAGSSSSNIITKEASRVAIEAVNALRKSRKKITKQYEI 949

  Fly  2667 ----------KKGNDEYIPRERDAL-------AALGLEEIQYGNWAKSE 2698
                      |.|.    .|:||.|       ||:      .||..||:
Yeast   950 GTPTWTGRFGKAGK----IRKRDPLKNKLTGSAAI------LGNITKSQ 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	46/268 (17%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	12/81 (15%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	9/57 (16%)
		PLN03142	2029..>2606	CDD:215601	181/639 (28%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
RAD26	NP_012569.1	HepA	<222..792	CDD:440319	183/602 (30%)
		CSB_WHD	1019..1080	CDD:439329