Protein Alignment kis and RAD54

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_011352.1
• Gene: RAD54 / 852713
• SGDID: S000003131
• Length: 898
• Species: Saccharomyces cerevisiae
• Alignment Length: 819
• Identity: 207/819 - (25%)
• Similarity: 338/819 - (41%)
• Gaps: 191/819 - (23%)

  Fly  1825 DSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNF 1889
            |.|.:||  |.|.:.:......:|.|:...:.:...|            |..:...:|.:: |:|
Yeast    82 DINADEA--EYNSQDISFSQLTKRRKDALSAQRLAKD------------PTRLSHIQYTLR-RSF 131

  Fly  1890 SYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNI--FENI--EDEPFNQDFTEVDRVL-DMS 1949
            :                    ..|:.:.|:.|..|.:  .:.|  |..|.:....|...|| |.|
Yeast   132 T--------------------VPIKGYVQRHSLPLTLGMKKKITPEPRPLHDPTDEFAIVLYDPS 176

  Fly  1950 VHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRP----- 2009
            |     .||...|           |.:.:.:|:.....|:.....:.| .:.:...::||
Yeast   177 V-----DGEMIVH-----------DTSMDNKEEESKKMIKSTQEKDNI-NKEKNSQEERPTQRIG 224

  Fly  2010 -HPELW-----------------------KKLEKTPVY---KGGNSLRPYQLEGL---------- 2037
             ||.|.                       ||....||.   |....|||:|:||:
Yeast   225 RHPALMTNGVRNKPLRELLGDSENSAENKKKFASVPVVIDPKLAKILRPHQVEGVRFLYRCVTGL 289

  Fly  2038 ---NWLKFSWYNT--------------------------HNCILADEMGLGKTIQSLTFVHSVYE 2073
               ::|:...:||                          :.||:|||||||||:|.:..:.::..
Yeast   290 VMKDYLEAEAFNTSSEDPLKSDEKALTESQKTEQNNRGAYGCIMADEMGLGKTLQCIALMWTLLR 354

  Fly  2074 YGIRGPFL-----VIAPLSTIPNWQREFEGWTDMNVV-----------VYHGSVTSKQMIQDYEY 2122
            .|.:|..|     ::.|.|.:.||..|...|...|.:           :..|:.|..|.|    :
Yeast   355 QGPQGKRLIDKCIIVCPSSLVNNWANELIKWLGPNTLTPLAVDGKKSSMGGGNTTVSQAI----H 415

  Fly  2123 YYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNL 2187
            .:....|:.:.:|    |||.::|.:..:...||..|..|.:.||.|||||.:......|..::.
Yeast   416 AWAQAQGRNIVKP----VLIISYETLRRNVDQLKNCNVGLMLADEGHRLKNGDSLTFTALDSISC 476

  Fly  2188 EHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS---------------LRTEEEVN 2237
            ..||:|||||:||::||.|:||:|..|....|:.||...|.:               .:.|.::.
Yeast   477 PRRVILSGTPIQNDLSEYFALLSFSNPGLLGSRAEFRKNFENPILRGRDADATDKEITKGEAQLQ 541

  Fly  2238 KLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNL 2302
            ||..::...::||..|.:.|.|..|.|.:|.|.|..:|.:.|..:::..  .:||..........
Yeast   542 KLSTIVSKFIIRRTNDILAKYLPCKYEHVIFVNLKPLQNELYNKLIKSR--EVKKVVKGVGGSQP 604

  Fly  2303 MNTMMELRKCCIHPYLLNGAEE---------QIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKL 2358
            :..:..|:|.|.||.|||..:|         ...|:.......|.::.|      :.|..::::.
Yeast   605 LRAIGILKKLCNHPNLLNFEDEFDDEDDLELPDDYNMPGSKARDVQTKY------SAKFSILERF 663

  Fly  2359 LPKLKA-NGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVF 2422
            |.|:|. :..::::.|...:.||::|....|:.|...|:||.:..|.||:.:||::.|....|:|
Yeast   664 LHKIKTESDDKIVLISNYTQTLDLIEKMCRYKHYSAVRLDGTMSINKRQKLVDRFNDPEGQEFIF 728

  Fly  2423 LLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDK 2487
            ||.:||||.||||..|:.:|:.|.||||..|.||.||..|.||:|...|||.:...|.|.::|.:
Yeast   729 LLSSKAGGCGINLIGANRLILMDPDWNPAADQQALARVWRDGQKKDCFIYRFISTGTIEEKIFQR 793

  Fly  2488 ASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKK 2526
            .|||:.|...|:.      :|:...:..|...:..|.:|
Yeast   794 QSMKMSLSSCVVD------AKEDVERLFSSDNLRQLFQK 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	16/97 (16%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	6/66 (9%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	12/58 (21%)
		PLN03142	2029..>2606	CDD:215601	164/578 (28%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
RAD54	NP_011352.1	Rad54_N	29..246	CDD:430137	38/215 (18%)
		HepA	<271..806	CDD:440319	160/550 (29%)
		DEXHc_RAD54A	271..554	CDD:350825	76/290 (26%)