Protein Alignment kis and ISW1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_009804.1
• Gene: ISW1 / 852547
• SGDID: S000000449
• Length: 1129
• Species: Saccharomyces cerevisiae
• Alignment Length: 1360
• Identity: 388/1360 - (28%)
• Similarity: 599/1360 - (44%)
• Gaps: 321/1360 - (23%)

  Fly  1767 KTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEA 1831
            |..||:...|:||...:.        :.:|.....::|..|..|:.|....|:|
Yeast    21 KKHENNSCNEKDKDENLF--------KIILAIFLQEKKKYDCISSGSIMTASEE----------- 66

  Fly  1832 TTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEW 1896
                         ..|.:|..:..:...:.|      .||        :.|.:|..|......|.
Yeast    67 -------------YLENLKPFQVGLPPHDPE------SNK--------KRYLLKDANGKKFDLEG 104

  Fly  1897 RTE--EELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGET 1959
            .|:  |.||.    ::...:.|.:.::        .:|..|.|       |||:...........
Yeast   105 TTKRFEHLLS----LSGLFKHFIESKA--------AKDPKFRQ-------VLDVLEENKANGKGK 150

  Fly  1960 TKHYLVKWKSLPY-EDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVY 2023
            .||..|:.:...: ||.....|||.|:|:..::                        :..::|.|
Yeast   151 GKHQDVRRRKTEHEEDAELLKEEDSDDDESIEF------------------------QFRESPAY 191

  Fly  2024 KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFV-HSVYEYGIRGPFLVIAPLS 2087
            ..| .|||||::|:|||.....|....|||||||||||:|:::|: :..|...|.||||||||.|
Yeast   192 VNG-QLRPYQIQGVNWLVSLHKNKIAGILADEMGLGKTLQTISFLGYLRYIEKIPGPFLVIAPKS 255

  Fly  2088 TIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPI---KFNVLITTFEMI 2148
            |:.||.||...|| |:|..:..|.              |.|..:::::.:   .|:|:|.::|:|
Yeast   256 TLNNWLREINRWTPDVNAFILQGD--------------KEERAELIQKKLLGCDFDVVIASYEII 306

  Fly  2149 VTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLE 2213
            :.:...||..||...:||||||:||....|.:.||:....:|:|::|||||||:.||::|||||.
Yeast   307 IREKSPLKKINWEYIIIDEAHRIKNEESMLSQVLREFTSRNRLLITGTPLQNNLHELWALLNFLL 371

  Fly  2214 PSQFSSQEEFMSEFGSLRTEEE----VNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNI 2274
            |..||..::|...|.|..|||:    |.:|..:|:|.:|||:|.|||.||.||:|..:.|.::::
Yeast   372 PDIFSDAQDFDDWFSSESTEEDQDKIVKQLHTVLQPFLLRRIKSDVETSLLPKKELNLYVGMSSM 436

  Fly  2275 QKKYYRGILEQNFSFLKKGTTS-ANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDP 2338
            |||:|:.|||::...:.....| .:...|:|.||:|||||.||||.:|||.           ..|
Yeast   437 QKKWYKKILEKDLDAVNGSNGSKESKTRLLNIMMQLRKCCNHPYLFDGAEP-----------GPP 490

  Fly  2339 ESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGN 2403
            .:..::|:.:|.|:.::||||.|||..|.||||||||.|.|||||||..:|.|.:.||||.....
Yeast   491 YTTDEHLVYNAAKLQVLDKLLKKLKEEGSRVLIFSQMSRLLDILEDYCYFRNYEYCRIDGSTAHE 555

  Fly  2404 LRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKM 2468
            .|.:|||.|:.|.|.:|||||.|:|||||||||:||.|::||||||||.||||..|.|||||:|.
Yeast   556 DRIQAIDDYNAPDSKKFVFLLTTRAGGLGINLTSADVVVLYDSDWNPQADLQAMDRAHRIGQKKQ 620

  Fly  2469 VKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAY---- 2529
            ||::||:..|:.|.::.::|:.||.||:.|:| .|....|...||..||..:..:::.||.
Yeast   621 VKVFRLVTDNSVEEKILERATQKLRLDQLVIQ-QNRTSLKKKENKADSKDALLSMIQHGAADVFK 684

  Fly  2530 ------GAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDPD 2588
                  .|...:..:|:|..:.|:|.:|        ::||..:....|.:...| ..|:...:.|
Yeast   685 SGTSTGSAGTPEPGSGEKGDDIDLDELL--------LKSENKTKSLNAKYETLG-LDDLQKFNQD 740

  Fly  2589 FWTKW-----AKKVDIDPDACERDETEDLVLSEPRRRTQIKRYG----HEDVMELNSEESSNE-- 2642
            ...:|     .||:       :||....|:|: |.:|.:.:.|.    ::||  ||:..||..
Yeast   741 SAYEWNGQDFKKKI-------QRDIISPLLLN-PTKRERKENYSIDNYYKDV--LNTGRSSTPSH 795

  Fly  2643 ---------NSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSE 2698
                     :|.:.....|:....||:...|: |.|   |:|...|..||       ||:.:..|
Yeast   796 PRMPKPHVFHSHQLQPPQLKVLYEKERMWTAK-KTG---YVPTMDDVKAA-------YGDISDEE 849

  Fly  2699 CFKVEKGLLSFGWGRWSELLELGQ-FKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLIT 2762
            ..|.:..||.........|.|..: .|..|......:..::             :.:.||
Yeast   850 EKKQKLELLKLSVNNSQPLTEEEEKMKADWESEGFTNWNKL-------------EFRKFI----- 896

  Fly  2763 PTEDGE-----VQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSS 2822
             |..|:     :|.|:|:      |.|     ||:.:|
Yeast   897 -TVSGKYGRNSIQAIARE------LAP-----GKTLEE--------------------------- 922

  Fly  2823 ALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLG--RHANKVLLRVRM 2885
                       :.|.|.|          .||..|:.:       .|:|:|.  .:..:.:.||:|
Yeast   923 -----------VRAYAKA----------FWSNIERIE-------DYEKYLKIIENEEEKIKRVKM 959

  Fly  2886 LYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGC---EMY 2947
                |.|.:...:.:.|:  |..:|.::.||:.:...:.....   |:.:|:..:|:|.   ::|
Yeast   960 ----QQEALRRKLSEYKN--PFFDLKLKHPPSSNNKRTYSEEE---DRFILLMLFKYGLDRDDVY 1015

  Fly  2948 RQMRADPNLCFV----------THVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTK 3002
            ..:|.:...|.:          |.|.....|:    |.|...|.:.|:    |..:||    .||
Yeast  1016 ELVRDEIRDCPLFELDFYFRSRTPVELARRGN----TLLQCLEKEFNA----GIVLDD----ATK 1068

  Fly  3003 DSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSEVLP 3062
            |    ::...|.....:..|....:. :..||..|...|.....|.:.|......:|.:|
Yeast  1069 D----RMKKEDENGKRIREEFADQTA-NEKENVDGVESKKAKIEDTSNVGTEQLVAEKIP 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	27/157 (17%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	12/68 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	14/58 (24%)
		PLN03142	2029..>2606	CDD:215601	246/601 (41%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
ISW1	NP_009804.1	PLN03142	108..1057	CDD:215601	348/1146 (30%)