Protein Alignment kis and RDH54

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_009629.6
• Gene: RDH54 / 852365
• SGDID: S000000277
• Length: 958
• Species: Saccharomyces cerevisiae
• Alignment Length: 1093
• Identity: 249/1093 - (22%)
• Similarity: 426/1093 - (38%)
• Gaps: 287/1093 - (26%)

  Fly  1650 VLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDK--PEGDEK-FKTEGESKKDLTDSEET 1711
            |::::..:||.||.:.|..:      ..::..|..||..  |:.:.| ||    ..:.:..::.|
Yeast     3 VISVKPRRREKILQEVKNSS------VYQTVFDSGTTQMQIPKYENKPFK----PPRRVGSNKYT 57

  Fly  1712 KLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIE 1776
            :|:.:|..|.:...|              |.|:.|:   .|....:.|  .....|...|..:.|
Yeast    58 QLKPTATAVTTAPIS--------------KAKVTVN---LKRSISAGP--TLNLAKKPNNLSSNE 103

  Fly  1777 EDKSSTVLTADHAKEPETVLEKMEVDE-----KANDDQ----SAVSKAEGSDEKSTDDSNPEEAT 1832
            ..:..|::    .::|.|...|....:     ||:.|:    :...|..||....:|..:..|..
Yeast   104 NTRYFTIM----YRKPTTKKHKTWSGDGYATLKASSDKLCFYNEAGKFLGSSMLPSDSDSLFETL 164

  Fly  1833 TEKNKESLEIEGEKERVKEGEE--SVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCE 1895
            .:.....::::.|   :||..|  |.|    |....:|.| |.|......|.....:|..
Yeast   165 FKAGSNEVQLDYE---LKENAEIRSAK----EALSQNMGN-PSPPTTSTTETVPSTKNDG----- 216

  Fly  1896 WRTEEELLKGDRRVAAKIRRFQQKQSQQLNI-----FENIEDEPFNQDFTEVDRVLDMSVHTDET 1955
                              .::|...||..::     |:::..:. |:..|.|.:       |.:.
Yeast   217 ------------------GKYQMPLSQLFSLNTVKRFKSVTKQT-NEHMTTVPK-------TSQN 255

  Fly  1956 SGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKT 2020
            | :..|:|.|                 .|.:||:..:..||   .:..:......|.|
Yeast   256 S-KAKKYYPV-----------------FDVNKIDNPIVMNK---NAAAEVDVIVDPLL------- 292

  Fly  2021 PVYKGGNSLRPYQLEGLNWLKFSW----------------------------YNTHNCILADEMG 2057
                 |..|||:|.||   :||.:                            .:...|:|||:||
Yeast   293 -----GKFLRPHQREG---VKFMYDCLMGLARPTIENPDIDCTTKSLVLENDSDISGCLLADDMG 349

  Fly  2058 LGKTIQSLTFVHSVYEY-----------------GIRGPFLVIAPLSTIPNWQREFEGWTDMNVV 2105
            ||||:.|:|.:.::...                 |:....||:.|::.|.||:|||..|.:::.:
Yeast   350 LGKTLMSITLIWTLIRQTPFASKVSCSQSGIPLTGLCKKILVVCPVTLIGNWKREFGKWLNLSRI 414

  Fly  2106 VYHGSVT-SKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMI--VTDYMDLKAFNWRLCVIDE 2167
               |.:| |.:...|.:   |......||....:.|||..:|.:  |::.::.......:.|.||
Yeast   415 ---GVLTLSSRNSPDMD---KMAVRNFLKVQRTYQVLIIGYEKLLSVSEELEKNKHLIDMLVCDE 473

  Fly  2168 AHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF----- 2227
            .|||||...|:|..|:.|::..::||:|||:||:::|.|::::|:.|....|...|...|
Yeast   474 GHRLKNGASKILNTLKSLDIRRKLLLTGTPIQNDLNEFFTIIDFINPGILGSFASFKRRFIIPIT 538

  Fly  2228 ----------------GSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQK 2276
                            |..|::|.:.    :.|..:|||....:||.|.||.:.|:      ..|
Yeast   539 RARDTANRYNEELLEKGEERSKEMIE----ITKRFILRRTNAILEKYLPPKTDIIL------FCK 593

  Fly  2277 KYYRGILEQNFSFLKKGTT----SANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGED 2337
            .|.:.||.  |..:.:|..    .....:.:..:..|:|.|..|.|:               |.|
Yeast   594 PYSQQILA--FKDILQGARLDFGQLTFSSSLGLITLLKKVCNSPGLV---------------GSD 641

  Fly  2338 PESYYKNLI------------LSAGKMVLIDKLLPKL-KANGHRVLIFSQMVRCLDILEDYLVYR 2389
            |  |||:.|            |::||:.::..||..: |....:|::.|...:.|||:|:.:...
Yeast   642 P--YYKSHIKDTQSQDSYSRSLNSGKLKVLMTLLEGIRKGTKEKVVVVSNYTQTLDIIENLMNMA 704

  Fly  2390 KYPFERIDGRIRGNLRQEAIDRYSK-PGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQND 2453
            .....|:||.|....|...:..::: |..  |.|||..|:||:|:||..|..:|::|:||||..|
Yeast   705 GMSHCRLDGSIPAKQRDSIVTSFNRNPAI--FGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVD 767

  Fly  2454 LQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKK 2518
            |||.:|.||.||:|...||||:.....:.::..:..||..|.:..|.....:..:..|:...:|:
Yeast   768 LQAMSRIHRDGQKKPCFIYRLVTTGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKE 832

  Fly  2519 EIEDLL------KKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASG 2577
            :::||.      |...:..:...|..|     |:|: ..:...|..|:|..|.||
Yeast   833 DLKDLFSVHTDTKSNTHDLICSCDGLG-----EEIE-YPETNQQQNTVELRKRST---------- 881

  Fly  2578 NRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHED 2630
                         |.|...:|:.....|....:|...|:..|:..: .|.|.|
Yeast   882 -------------TTWTSALDLQKKMNEAATNDDAKKSQYIRQCLV-HYKHID 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	53/286 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	11/68 (16%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	10/57 (18%)
		PLN03142	2029..>2606	CDD:215601	171/669 (26%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
RDH54	NP_009629.6	DUF2439	108..>158	CDD:463065	11/53 (21%)
		DEXHc_RAD54	296..573	CDD:350762	74/289 (26%)
		SF2_C_SNF	663..789	CDD:350180	47/127 (37%)