Protein Alignment kis and FUN30

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_009383.1
• Gene: FUN30 / 851214
• SGDID: S000000017
• Length: 1131
• Species: Saccharomyces cerevisiae
• Alignment Length: 1227
• Identity: 315/1227 - (25%)
• Similarity: 497/1227 - (40%)
• Gaps: 282/1227 - (22%)

  Fly  1491 VPESDGEDDTLDRTP--PPSPP-PDSEMDSNKRR-------SSRNTQRKKYI----DDVML---- 1537
            |||:.........:|  |.||. ||:.:.|.:.|       .|......|.:    .:|.|
Yeast    15 VPETSSPTKVASSSPLKPTSPTVPDASVASLRSRFTFKPSDPSEGAHTSKPLPSGSPEVALVNLA 79

  Fly  1538 RFSDDENSLLVASPVKKDKKPSANAS---------------NSNAGSDVEKTEPQSGAEGDAAQE 1587
            |...|.:..||.:..|.:.....:|.               |.||.....:|.|
Yeast    80 REFPDFSQTLVQAVFKSNSFNLQSARERLTRLRQQRQNWTWNKNASPKKSETPP----------- 133

  Fly  1588 VGEEKSNLPLDESSQLEA-------SSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSM 1645
              ..|.:|||..:.:|.:       .||...||:::..|....:|.....:..:......:.||.
Yeast   134 --PVKKSLPLANTGRLSSIHGNINNKSSKITVAKQKTSIFDRYSNVINQKQYTFELPTNLNIDSE 196

  Fly  1646 VVQLVLAMRMGKRELILDKPKEKAPEPKQDEEK--SELDEATTDKPEGDEKFKTEGESKKDLTDS 1708
            .:..:......||.|:           :.|:..  ...:.:.|......||.....:..:...|:
Yeast   197 ALSKLPVNYNKKRRLV-----------RADQHPIGKSYESSATQLGSAREKLLANRKYGRHANDN 250

  Fly  1709 EETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEV---DDEVGKSDKESKPEEQSET----- 1765
            :|.:.||  |..|..:.|..|.::.:.:.|.|:..::.   .|.|..||.......:::.
Yeast   251 DEEEEES--MMTDDDDASGDDYTESTPQINLDEQVLQFINDSDIVDLSDLSDTTMHKAQLIASHR 313

  Fly  1766 --------VKTEENSKAIEEDKSS--TVLTADHAKEPETVLEKMEVDEKA-NDDQSAVSK----- 1814
                    |.|..|.|..||:.|:  ....|..|.|.|.:|:|:....:. |..:|.:.|
Yeast   314 PYSSLNAFVNTNFNDKDTEENASNKRKRRAAASANESERLLDKITQSIRGYNAIESVIKKCSSYG 378

  Fly  1815 -------------AEG------------SDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEE 1854
                         .||            .|:...||.|.:...:..|..:......||  ||..:
Yeast   379 DLVTSQMKKWGVQVEGDNSELDLMNLGEDDDDDNDDGNNDNNNSNNNNTAGADATSKE--KEDTK 441

  Fly  1855 SVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQK 1919
            :|.:..|| |.|  |..|.|....||....:.||        .|:.::
Yeast   442 AVVEGFDE-TSA--EPTPAPAPAPVERETKRIRN--------TTKPKV----------------- 478

  Fly  1920 QSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVD 1984
                      :|||..:.|...:|..|..|.|.|:...|..:.|..:.:.:.|:|..   ::|.|
Yeast   479 ----------VEDEDDDVDLEAIDDELPQSEHEDDDYEEEDEDYNDEEEDVEYDDGD---DDDDD 530

  Fly  1985 NDK----------IEQYLRFNKIPQRSEWKSKKR-PHPELWKKLEKTPVYKGGNSLRPYQLEGLN 2038
            :|:          |....|..:.|....:|.|.| ..||:              ||:.||..|:|
Yeast   531 DDEFVATRKNTHVISTTSRNGRKPIVKFFKGKPRLLSPEI--------------SLKDYQQTGIN 581

  Fly  2039 WLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTD-M 2102
            ||...:.|..:|||||:||||||.|.::|...:.:....||.||:.|.||:.||.|||:.:.. :
Yeast   582 WLNLLYQNKMSCILADDMGLGKTCQVISFFAYLKQINEPGPHLVVVPSSTLENWLREFQKFAPAL 646

  Fly  2103 NVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMD---LKAFNWRLCV 2164
            .:..|:||:..::.::|   ..:..:|       |::|::||:.:...:..|   ||..|:.:.|
Yeast   647 KIEPYYGSLQEREELRD---ILERNAG-------KYDVIVTTYNLAAGNKYDVSFLKNRNFNVVV 701

  Fly  2165 IDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQF-SSQEEFMSEF- 2227
            .||.|.|||...:....|.::....|:||:|||||||:.||.|||.|:.|:.| |.:|.|.:.|
Yeast   702 YDEGHMLKNSTSERFAKLMKIRANFRLLLTGTPLQNNLKELMSLLEFIMPNLFISKKESFDAIFK 766

  Fly  2228 ------------GSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYY- 2279
                        ..|..:|.:.:.:.::||.:|||.||.|.|.|.||...|...||..||||.|
Yeast   767 QRAKTTDDNKNHNPLLAQEAITRAKTMMKPFILRRRKDQVLKHLPPKHTHIQYCELNAIQKKIYD 831

  Fly  2280 ---RGILEQNFSFLKKG--------TTSANIPNLMNTMMELRKCCIHP----------------- 2316
               :.:||.. ..:|.|        .:.....:..|.:|.|||..:||
Yeast   832 KEIQIVLEHK-RMIKDGELPKDAKEKSKLQSSSSKNLIMALRKASLHPLLFRNIYNDKIITKMSD 895

  Fly  2317 -------YLLNGAEEQIQYDFKSQHGEDPESY-----YKNLI----------LSAGKMVLIDKLL 2359
                   |..||.:|.|:.|.  .:..|.|.:     :.|.:          :.:||:..:.|||
Yeast   896 AILDEPAYAENGNKEYIKEDM--SYMTDFELHKLCCNFPNTLSKYQLHNDEWMQSGKIDALKKLL 958

  Fly  2360 PKLKAN-GHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFL 2423
            ..:..: ..:|||||...:.|||||..|....|.|.|:||..:.|.||..||::.: ..|..:|:
Yeast   959 KTIIVDKQEKVLIFSLFTQVLDILEMVLSTLDYKFLRLDGSTQVNDRQLLIDKFYE-DKDIPIFI 1022

  Fly  2424 LCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKA 2488
            |.|||||.||||..|:.|||:|..:||.:|.||..|.||:||.|.|.|..|:.:::.|.::...|
Yeast  1023 LSTKAGGFGINLVCANNVIIFDQSFNPHDDRQAADRAHRVGQTKEVNITTLITKDSIEEKIHQLA 1087

  Fly  2489 SMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEE 2545
            ..||.||..:        |:|..::.:.:.::.|:|:...|     |:|:..|..:|
Yeast  1088 KNKLALDSYI--------SEDKKSQDVLESKVSDMLEDIIY-----DENSKPKGTKE 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	3/8 (38%)
		PTZ00121	<1419..1923	CDD:173412	100/522 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	14/66 (21%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	15/67 (22%)
		PLN03142	2029..>2606	CDD:215601	190/587 (32%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
FUN30	NP_009383.1	HepA	<571..1093	CDD:440319	180/535 (34%)