Protein Alignment kis and TTF2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_016858039.1
• Gene: TTF2 / 8458
• HGNCID: 12398
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1137
• Identity: 245/1137 - (21%)
• Similarity: 412/1137 - (36%)
• Gaps: 362/1137 - (31%)

  Fly  1658 RELILDKPKEKAPEPKQDEEKSEL-DEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVD 1721
            ::||..:.:||..:.||.|:..:| |:....|||..|         |||:.....|.:.|.::..
Human   139 KQLIKGEGEEKKADKKQREKGDQLFDQKKEQKPEMME---------KDLSSGLVPKKKQSVVQEK 194

  Fly  1722 SKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSK--AIEEDKSSTVL 1784
            .:||..               :::.:.|.|.:.|....|.:|:..:..|.::  |..::|||. .
Human   195 KQEEGA---------------EIQCEAETGGTHKRDFSEIKSQQCQGNELTRPSASSQEKSSG-K 243

  Fly  1785 TADHAKEPETVLEKM-EVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKER 1848
            :.|..:|.|.:.||: ::..:.....:::||.:.....:.:.:| .||...|.|:...|:..::.
Human   244 SQDVQRESEPLREKVTQLLPQNVHSHNSISKPQKGGPLNKEYTN-WEAKETKAKDGPSIQATQKS 307

  Fly  1849 VK---------------------------------EGEESVKKENDEKTEAD---MENKP-EPVF 1876
            :.                                 ||.|:....:||: |.|   :.:|| .|:.
Human   308 LPQGHFQERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATSSDDEE-EDDVVFVSSKPGSPLL 371

  Fly  1877 IDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKI-----------------RR------FQQ 1918
            .|           |.|..|  |:|.|...||.|..|:                 ||      .:|
Human   372 FD-----------STLDLE--TKENLQFPDRSVQRKVSPASGVSKKVEPSDPVARRVYLTTQLKQ 423

  Fly  1919 KQSQQLNIFENIEDEPFN--------QDFTEVDRVLDMSVH--TDETSGE------------TTK 1961
            |:|...::  ||:..|..        |:..||...|.:|..  |:|.|..            |..
Human   424 KKSTLASV--NIQALPDKGQKLIKQIQELEEVLSGLTLSPEQGTNEKSNSQVPQQSHFTKTTTGP 486

  Fly  1962 HYLVKWKSLP--------------------------YEDCTWELEEDVDNDKIEQYLRFNKIPQR 2000
            .:||..:.||                          |...|:......:.|.:           .
Human   487 PHLVPPQPLPRRGTQPVGSLELKSACQVTAGGSSQCYRGNTYLYAGHTNQDHV-----------H 540

  Fly  2001 SEWKSKKRPHPELWKKLEKTPVYKGGNS------------LRPYQLEGLNWLKFSWYNT---HNC 2050
            :.||.......:|.:.||..|    |.:            |..:|.:.|.||  .|..:   ...
Human   541 AVWKITSEAIGQLHRSLESCP----GETVVAEDPAGLKVPLLLHQKQALAWL--LWRESQKPQGG 599

  Fly  2051 ILADEMGLGKTIQSLTFV-----------------------HSVYEYGIRGPFLVIAPLSTIPNW 2092
            ||||:||||||:..:..:                       ....::...|. |:|.|.|.|.:|
Human   600 ILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTALTWLSKDDSCDFTSHGT-LIICPASLIHHW 663

  Fly  2093 QREFEGWTDMN---VVVYHG--------------------SVTSKQM---------------IQD 2119
            :.|.|...:.|   |.:|||                    |:.:|::               ::.
Human   664 KNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEAEIPGANLNVET 728

  Fly  2120 YEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQ 2184
            ...:|  .||.|.....:|.:..|:..::        ...|...::||||.:||...:....:.:
Human   729 LSIHY--GSGAVSSRAARFPLQGTSTPLL--------RIAWARIILDEAHNVKNPRVQTSIAVCK 783

  Fly  2185 LNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF--GSLRTEEEVNKLQALLKPMM 2247
            |....|..::|||:|||:.:::|||.||..|.|.....:.|:.  ||.:..|   :|..|.|.::
Human   784 LQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGGE---RLSILTKSLL 845

  Fly  2248 LRRLKDDVEKS------------------LAPKEETIIEVELTNIQKKYYRGILEQNFSFLK--- 2291
            |||.||.::.:                  |:..|||:..|....     .|..|:   |:||
Human   846 LRRTKDQLDSTGRPLVILPQRKFQLHHLKLSEDEETVYNVFFAR-----SRSALQ---SYLKRHE 902

  Fly  2292 -KGTTSANIPN------------------------------LMNTMMELRKCCIHPYLLNGA--- 2322
             :|..|...||                              :::.::.||:||.|..||..|
Human   903 SRGNQSGRSPNNPFSRVALEFGSEEPRHSEAADSPRSSTVHILSQLLRLRQCCCHLSLLKSALDP 967

  Fly  2323 ------------EEQIQ-YDFKSQHGEDPES-------YYK-NLILSAGKMVLIDKLLPKLKA-- 2364
                        |||:. .........:|.|       ::| .|.....:...|..||.:|:|
Human   968 MELKGEGLVLSLEEQLSALTLSELRDSEPSSTVSLNGTFFKMELFEGMRESTKISSLLAELEAIQ 1032

  Fly  2365 ---NGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCT 2426
               ...:.:|.||....|.::..:|......:..|||.:....|.:.::.::.....: |.|:..
Human  1033 RNSASQKSVIVSQWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQ-VMLISL 1096

  Fly  2427 KAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMK 2491
            .|||:|:|||..:.:.:.|..|||..:.||..|.:|:||:|.|.|:|.:|..|.|.::......|
Human  1097 LAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFVCEGTVEEKILQLQEKK 1161

  Fly  2492 LGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDL 2523
            ..|.|.||         .|:.:.::|..:.||
Human  1162 KDLAKQVL---------SGSGESVTKLTLADL 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	69/328 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	23/93 (25%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	16/97 (16%)
		PLN03142	2029..>2606	CDD:215601	150/642 (23%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
TTF2	XP_016858039.1	zf-GRF	4..39	CDD:480736
		PTZ00108	<147..378	CDD:240271	54/268 (20%)
		HepA	<566..1170	CDD:440319	146/637 (23%)
		DEXHc_TTF2	577..848	CDD:350830	68/286 (24%)