DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and EDA16

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_176309.2 Gene:EDA16 / 842407 AraportID:AT1G61140 Length:1280 Species:Arabidopsis thaliana


Alignment Length:1485 Identity:292/1485 - (19%)
Similarity:494/1485 - (33%) Gaps:544/1485 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1359 GEDGAEQTGEGSEVEDN----------KPLVPKAGSADGEAETTS--GGTGVDGESPDYDDIPVS 1411
            ||...:....|.|.||:          :.|..|..||:|..|..|  |.:.        |::..|
plant    12 GEFPVDDCDGGFEFEDDDETIDIETLYRILDEKPDSAEGSQENLSPVGSSA--------DELKDS 68

  Fly  1412 KIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSL 1476
            ::..||.::..:.|||         .:..||.|.|                     ::.|:..||
plant    69 QLLNGSFDEHVKMEAG---------LSPSPAHTCS---------------------ASLKDWFSL 103

  Fly  1477 SAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSD 1541
            |         :|....|:.|..             .|||.|....||               |||
plant   104 S---------QGEQPVETCGVS-------------QSEMTSCSISSS---------------FSD 131

  Fly  1542 DENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNL-PLDESSQ--- 1602
            .:.:::..:||               ..||:....|.       .::.:.||.| |..::..   
plant   132 PDGNMMAFNPV---------------NCDVDTVSKQD-------DKIIDSKSMLTPYFDNVTGYG 174

  Fly  1603 --LEASSSTSAVAEKERQISTDAANAAMSSKPNYV------YINTGDEDSMVVQLVLAMRMGKRE 1659
              |.|:.::||::     :..:.:|:...|..|||      |..:|...|               
plant   175 VGLGANHNSSAMS-----VFFNNSNSLSDSADNYVSSAQDCYNTSGTSLS--------------- 219

  Fly  1660 LILDKPKEKAPEPKQD---EEKSELDEATTDKPEGDEKFKTEGESKKDLTDS----EETKLE--- 1714
                   :..|...|:   |.....:||..|...|..:.:::|.|:. :.|.    :...||   
plant   220 -------DHTPNSVQNFAFEFFPNKEEAVNDVESGVSESQSDGASRM-IFDRHGRVDNGSLERKP 276

  Fly  1715 ----SSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAI 1775
                |||..:..|.||.|..|....:.....|....|.::.:.:..|...:.::||         
plant   277 PIDFSSARGISFKFESNPSVSPACVKPYNSFDSHLADSDLDRPNNYSCSFQDNKTV--------- 332

  Fly  1776 EEDKSSTVLTADHAK-EPETVLEKMEVDEKANDDQSAVSKAEG-----SDEKSTDDSNPEEATTE 1834
                        |.| :||...||:           ..|...|     .|...:.::|...:...
plant   333 ------------HVKVKPEAESEKV-----------VYSSVPGEFSVRDDAYLSGETNRWWSGAS 374

  Fly  1835 KNKESLEIEGEK-------ERVKEGEESVKKENDEKTEAD-----MENKPEPVFIDVEEYFVKYR 1887
            .:..|.:.:.||       :.....::|.|..::...::|     :...|.||..:.|     |:
plant   375 SSAVSYQTDIEKGYSYMAPQTALPSQDSGKISSNHFYDSDTCLQYVVEDPSPVTQNNE-----YK 434

  Fly  1888 NFSYLHCEWRTEEELLKGDRR------VAAKIRR--FQQKQSQQLNIFENIED-------EPFNQ 1937
            :|           ::.:|||.      :.::...  |:..||.......:.:|       ||:.|
plant   435 DF-----------QIQQGDREYIQPRGIDSQFSNASFESVQSHSSECISDSDDDSDVCIIEPYGQ 488

  Fly  1938 DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSE 2002
            .... .|.|.|.:....:...|..|...:...|       :|:.:.:|...:..|          
plant   489 SAIP-HRPLAMKMPVVSSEYSTVSHNFNQSGGL-------KLQSNKENMIFQAAL---------- 535

  Fly  2003 WKSKKRPHPE--LWKKLEKTPVYKGGNSLRPYQLEGLNWL---KFSWYNTHNCILADEMGLGKTI 2062
             :...:|:.|  |...:...|:.:       :|...|:|:   :.|.:.....||||:.|||||:
plant   536 -QDLTQPNSEAILPDGVLTVPLLR-------HQRIALSWMAQKETSGFPCSGGILADDQGLGKTV 592

  Fly  2063 QSLT------------------------------------------FVHSVY---EYGIRGP--- 2079
            .::.                                          |.||..   |..:.|.   
plant   593 STIALILKERSKPAQACEESTKKEIFDLESETGECAPLKPSGRSKHFEHSQLLSNENKVGGDSVG 657

  Fly  2080 ---------FLVIAPLSTIPNWQREFE----GWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKV 2131
                     .||:.|.|.:..|..|..    ...:::|:|||||..:|..               
plant   658 KVTGRPAAGTLVVCPTSVMRQWADELHKKVTSEANLSVLVYHGSSRTKDP--------------- 707

  Fly  2132 LKEPIKFNVLITTFEMI--------VTDYMD---------------------------------- 2154
             .|..|::|::|||.::        :.|..|                                  
plant   708 -HELAKYDVVVTTFSIVSMEVPKQPLVDDEDEEKDGVHDGGTAATGFCSNKKRKYPPDSKKKGSK 771

  Fly  2155 ----------LKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLL 2209
                      |...:|...|:|||..:||...::......|..:.|..|||||:||:|.:|:|..
plant   772 KKKVEFLSGPLAKVSWFRVVLDEAQSIKNYKTQVARACWGLRAKRRWCLSGTPIQNSIDDLYSYF 836

  Fly  2210 NFLEPSQFSSQEEFMSEFGSLRTEEEV---NKLQALLKPMMLRRLKDDVEK-----SLAPKEETI 2266
            .||:...:||...|.|...:..|...|   .||||:||.:||||.|..:..     ||.||...:
plant   837 RFLKYDPYSSYVLFCSTIKNPITRNPVKGYQKLQAILKTVMLRRTKGSLLDGKPIISLPPKSIEL 901

  Fly  2267 IEVELTNIQKKYYRGILEQNFS----FLKKGTTSANIPNLMNTMMELRKCCIHPYLLNG------ 2321
            .:|:.|..::.:|..:..::.:    :.:.||...|..|::..::.||:.|.||.|:||      
plant   902 RKVDFTVEERDFYSKLEAESRTQFREYAEAGTVKQNYVNILLMLLRLRQACDHPLLVNGEYSFTW 966

  Fly  2322 ------AEEQIQYD------------------------------FKSQHGEDPESYYKN----LI 2346
                  |::|||.|                              ::...|:.....:.|    |.
plant   967 ESSVGLAKKQIQSDASLAICGICNDAPEDAVASVCGHVFCKQCIYERLTGDSNHCPFANCNVRLT 1031

  Fly  2347 LS--AGKMVLIDKL------------------------------------LPK------------ 2361
            :|  :.|..|.|.:                                    |||            
plant  1032 ISSLSSKTRLDDAMPDMQERATSNSLSPCSDEDLPYGSSKIKAALEILQSLPKAHDLTDSNQISE 1096

  Fly  2362 ----------------------LKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNL 2404
                                  :|..|.:.::|||..:.|::||..||.....:.|:||.:....
plant  1097 NREYSGLSITPVKNEGMSVDVPIKVAGEKAIVFSQWTKMLNLLEASLVSSHIQYRRLDGTMSVAA 1161

  Fly  2405 RQEAIDRYSK-PGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKM 2468
            |.:|:..::. |  :..|.::..||..||:|:.||..|::.|..|||..:.||..|.|||||.:.
plant  1162 RDKAVQDFNTLP--EVTVMIMSLKAASLGLNMVAACHVLMLDLWWNPTTEDQAIDRAHRIGQTRP 1224

  Fly  2469 VKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDL 2523
            |.:.|...::|.|..:       |.|.:.....:.:...:|....:.|...:|||
plant  1225 VTVVRFTVKDTVEDRI-------LALQQKKRMMVASAFGEDEKGSRQSHLTVEDL 1272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171 32/152 (21%)
PTZ00121 <1419..1923 CDD:173412 97/555 (17%)
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315 13/79 (16%)
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 10/57 (18%)
PLN03142 2029..>2606 CDD:215601 160/742 (22%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
EDA16NP_176309.2 HepA <547..1256 CDD:440319 157/740 (21%)
RING-HC_CHR27-like 984..1035 CDD:438504 4/50 (8%)
Blue background indicates that the domain is not in the aligned region.

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