Protein Alignment kis and CHD6

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_016883588.1
• Gene: CHD6 / 84181
• HGNCID: 19057
• Length: 2716
• Species: Homo sapiens
• Alignment Length: 3624
• Identity: 1095/3624 - (30%)
• Similarity: 1534/3624 - (42%)
• Gaps: 1150/3624 - (31%)

  Fly  1593 SNL------PLDESS---QLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQ 1648
            |||      |:.::|   ..::.|......::|.:|. |.|:..:..|..|    |.:|::..
Human    14 SNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIE-DVASHCLPQKDLY----TAEEEAAT-- 71

  Fly  1649 LVLAMRMGKRELILD--------KPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESK--K 1703
             :...:|.....:.|        |.|.|..||                  ||:    ||.:|  |
Human    72 -LFPRKMTSHNGMEDSGGGGTGVKKKRKKKEP------------------GDQ----EGAAKGSK 113

  Fly  1704 DLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKT 1768
            |.....:.|          :|..||.:.:|:.|..|.|:..|...:.| :.|..||.|.|.|.:.
Human   114 DREPKPKRK----------REPKEPKEPRKAKEPKKAKEHKEPKQKDG-AKKARKPREASGTKEA 167

  Fly  1769 EE------------NSKAIEEDKSSTVLTADHAK-EPETVLEKMEVDEKANDDQSAVSKAEGSDE 1820
            :|            :.||.:|...:.|......| :.||.:|.:|:      ||...:.:..|.|
Human   168 KEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESLEL------DQGLTNPSLRSPE 226

  Fly  1821 KSTDDSNPE------EATTEKNKESLEI-----EGE----------------------KERVKEG 1852
            :||:.::.:      :....|..|.|:.     :||                      :|..::.
Human   227 ESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDD 291

  Fly  1853 EESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQ 1917
            ...::|....||..:: :..||.| |:|.::|||||||||||:|.|.|||.| |.|:|.||:||:
Human   292 ANIIEKILASKTVQEV-HPGEPPF-DLELFYVKYRNFSYLHCKWATMEELEK-DPRIAQKIKRFR 353

  Fly  1918 QKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEED 1982
            .||:|..:||...:::.||.|:.||||:|:::...|..:||...||||||.|||||:.|||||||
Human   354 NKQAQMKHIFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEED 418

  Fly  1983 VDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNT 2047
            ||..|::::.....:|   |.|..:||..:.|:||||:..||..|.||.|||||:|||.|:|||.
Human   419 VDPAKVKEFESLQVLP---EIKHVERPASDSWQKLEKSREYKNSNQLREYQLEGMNWLLFNWYNR 480

  Fly  2048 HNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTDMNVVVYHGSVT 2112
            .||||||||||||||||:||:..::..||.||||:|||||||.||:|||..||:||.:|||||..
Human   481 KNCILADEMGLGKTIQSITFLSEIFLRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYHGSQI 545

  Fly  2113 SKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCK 2177
            |:||||.||..|:...|..|....||:|:|||||||:.|..:||..:|...:|||||||||||||
Human   546 SRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCK 610

  Fly  2178 LLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQAL 2242
            |||||:.:.|||:|||:||||||::.||||||||||||||.|:..|:.|||.|:|||:|.|||::
Human   611 LLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSI 675

  Fly  2243 LKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMM 2307
            |||||||||||||||:||||:|||||||||||||||||.|||:|||||.||....|:|||:||||
Human   676 LKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMM 740

  Fly  2308 ELRKCCIHPYLLNGAEEQIQYDFKSQHGED-PESYYKNLILSAGKMVLIDKLLPKLKANGHRVLI 2371
            ||||||.||||:|||||:|..||:..|..| |:...:.:|.:|||:||||||||||.|.||:|||
Human   741 ELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLI 805

  Fly  2372 FSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLT 2436
            |||||||||||||||:.|:|.:||||||:||||||.||||:.||.||||||||||:|||||||||
Human   806 FSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLT 870

  Fly  2437 AADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQS 2501
            ||||.||:|||||||||||||||||||||.|.||:|||:.||:||||||||||:||||||||||.
Human   871 AADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQD 935

  Fly  2502 MNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESE-KG 2565
            :|.:|..:| .:||||.|:||||:||||||:||:::.|.||||||||.||:|||..||::|| ||
Human   936 INRKGGTNG-VQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKG 999

  Fly  2566 STFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYG--- 2627
            |||:||||.|||||:||::|||:||.||||..::|.:|  ::|.|.||:..||.|.|.|.|.
Human  1000 STFAKASFVASGNRTDISLDDPNFWQKWAKIAELDTEA--KNEKESLVIDRPRVRKQTKHYNSFE 1062

  Fly  2628 HEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYG 2692
            .:::||.:..:|   :|||      |..|.:...|:||
Human  1063 EDELMEFSELDS---DSDE------RPTRSRRLNDKAR--------------------------- 1091

  Fly  2693 NWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFI 2757
            .:.::|||:|||.||.||||||.::|..|:||....:.|:|...|.:|:||::.||||||||:||
Human  1092 RYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYKGDEKIKSFI 1156

  Fly  2758 WDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSS 2822
            |:|||||:||:.|.: ::||||...|||||.|.|:                           |:.
Human  1157 WELITPTKDGQAQTL-QNHSGLSAPVPRGRKGKKT---------------------------KNQ 1193

  Fly  2823 ALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLY 2887
            .|....||:..:   |.......:||                 ..|||||.:|.|||||||||||
Human  1194 LLIPELKDADWL---ATCNPEVVLHD-----------------DGYKKHLKQHCNKVLLRVRMLY 1238

  Fly  2888 YIQHEVIGDFVQQIKDNTPISELPIRPPPTPD----QVPSSWWNPICCDKSLLVGTYKHGCEMYR 2948
            |::.|::|:..::..:.:|..||.:   |.||    ::|..||:.. .|||||:|.:|||.|.|.
Human  1239 YLKAEILGEAAEKAFEGSPARELDV---PLPDIDYMEIPVDWWDAE-ADKSLLIGVFKHGYERYN 1299

  Fly  2949 QMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGD 3013
            .|||||.|||:..||            :|   |:.:...:.|   ..|||:..
Human  1300 AMRADPALCFLEKVG------------MP---DEKSLSAEQG---VTDGTSDI------------ 1334

  Fly  3014 NKDSLLDPERPSSSGKSSSENASGGNDK-TESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDA 3077
                   |||.::..:.::|:...|..| |||.:|.
Human  1335 -------PERGNTDKEDNAEDKVDGLQKQTESSSDG----------------------------- 1363

  Fly  3078 LSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNE 3142
                                                             ||.    :.|||||:
Human  1364 -------------------------------------------------GDG----VFSEKKDD- 1374

  Fly  3143 KETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNISTTTTTTTITNTTTTTNNPSSKAA 3207
                                                                         |:||
Human  1375 -------------------------------------------------------------SRAA 1378

  Fly  3208 NSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKE 3272
            ..             |.|.::|                 .||....|..||||::|.|||..:||
Human  1379 QD-------------GSDPDKS-----------------PWPVSSALTARLRRLVTVYQRCNRKE 1413

  Fly  3273 ELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDASGRSLQALMQS 3337
            ..:                      |.:
Human  1414 LCR----------------------PEI------------------------------------- 1419

  Fly  3338 QGASTSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADISLMLSILNTTDVNQLANLDINK 3402
                                     :|.|..|
Human  1420 -------------------------LGPGNQG--------------------------------- 1426

  Fly  3403 LAMYLVSMNNKMERQGKMELAAKERESQRLQLIPKKWNRREEYEFLRVLTGYGV--DLHVSTPMA 3465
               |.| ......|..:|:|..||.:        |:|.|||:.:|.|.::.:||  |....|
Human  1427 ---YWV-QEEMFRRTSEMDLINKEAQ--------KRWTRREQADFYRTVSSFGVVYDQEKKT--- 1476

  Fly  3466 SSNGSSLSPDWTKFKQMAHLERKSDETLTDYYKVFVAMCKRQAGLKLSESERGLEG-------II 3523
                    .|||:|:.::.|::||||:|..|:..|||||:....|...:     :|       .:
Human  1477 --------FDWTQFRIISRLDKKSDESLEQYFYSFVAMCRNVCRLPTWK-----DGGPPDTTIYV 1528

  Fly  3524 EEIEKEHAKLILDRLEVLAKLRE-VARNPMLEERLKLCTKNADTPDWWEPGRHDKELITAVLKHG 3587
            |.|.:|.|...|.|:|:|.|:|| |.:.|.|.|||:||..:...|.|||.|:||::|:....|||
Human  1529 EPITEERAARTLYRIELLRKVREQVLKCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHG 1593

  Fly  3588 LYRSETFIFNDPNFSFGESEKRFIRELEAQIQ---RTIKLEAFNAEKAEKLAAAEKDAATEKAAA 3649
            |.|::.:|.|||..||.::.:.:.:...:..|   ....|...|::..|.|..::....:|
Human  1594 LNRTDCYIMNDPQLSFLDAYRNYAQHKRSGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSE---- 1654

  Fly  3650 TEKAAAEKAASVKNEVIDL------DDEL----MTNESVIKKESPVTPIKEEIKSEESPEKHDTA 3704
                      |::||..:|      ||.|    :|.|:.|.|...|..|           .||
Human  1655 ----------SLENEPENLVRVESRDDHLSLPDVTCENFISKVQDVISI-----------NHD-- 1696

  Fly  3705 DNLEDKNSDAEESTKIKGKEDFNPETTE-----KEALDESTNLNKDKSSTETLVPEIEDSKPSED 3764
                               |...||:.|     |:.|.:..:..::..||.|           |.
Human  1697 -------------------ESLLPESLESMMYGKKVLSQEPSSFQESPSTNT-----------ES 1731

  Fly  3765 KMEVEELPVAENGE-KEGSPEKCSDAEDKKFSEEKPSSPAVPDGKVSEMEADEAAPNTEEN---- 3824
            :.:|..:.::::|. :.|.||           .|..|.|..    :..:||...|....:|
Human  1732 RKDVITISISKDGNCQSGGPE-----------AEIASGPTF----MGSLEAGGVAQANIKNGKHL 1781

  Fly  3825 -----------CSGDSESPEK--ECEDKVVEKVEEEKGE-------------NSYEKAEEQKEET 3863
                       ||...:.||.  :.|.|.:.......|.             :|.......::..
Human  1782 LMSISKEGELCCSEAGQRPENIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQQLI 1846

  Fly  3864 EKLEKSSIESE--------PSEKSETVLEPEVAVPKKSTGDQ-DILDLVAGPSDPDDDEVMKEKE 3919
            :.||..|:||:        ..|:.|...|.|........|:: ::|.|    ::|..: :.:||.
Human  1847 DLLENKSLESKLILSQNHSDEEEEEEENEEENLAMAVGMGERPEVLHL----TEPTTN-ISREKN 1906

  Fly  3920 KAVEEECKKQAAELKARFPDLEVIQPATVKQQKLEKPKLEMC----MIRWF-----KDFALERRI 3975
            :..::|.||.:.|:..:.|.|:...||         |....|    |.||.     .:|.:|:..
Human  1907 QGFQDETKKGSLEVANQTPGLQRAFPA---------PAACQCHCKHMERWMHGLENDEFEIEKPK 1962

  Fly  3976 AHIVACVESGNWPVDSKYSAFA-----TCKGATDLSIALHESI--PHLSSLERRSTTPDVITITT 4033
            |:|....:       ||.:..|     |...:....:. ||.:  |...|.|.::..|
Human  1963 AYIPDLFK-------SKTNTIAMEGEPTAIPSQPFKVK-HELLKEPWKESAEGQNVFP------- 2012

  Fly  4034 DQGVTKHLQTS---------------------HMQQVA---SSASAASTSSG------------- 4061
                |..|:.|                     |.|...   |...:.|::||
Human  2013 ----TYPLEGSELKSEDMDFENKDDYDRDGNCHSQDYPGKYSEEESKSSTSGITGDIGDELQEAR 2073

  Fly  4062 ---VPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLPGMSL-SAATGSSAG 4122
               :.|:.|.|...|.|....|...||.  ...:......|...|.....|..:| :....||||
Human  2074 APTIAQLLQEKTLYSFSEWPKDRVIINR--LDNICHVVLKGKWPSSQQYEPSGTLPTPVLTSSAG 2136

  Fly  4123 GVSGLSVPSAGSGVGKKRKRHIAIDVETERAKLHALLNSSTMAP---KDWESEIANMEALSGSSG 4184
            ..:.||.|.|.        .|...:.....|::|   ..|.:||   ||.:......|.......
Human  2137 SRTSLSEPEAA--------EHSFSNGAALAAQIH---KESFLAPVFTKDEQKHRRPYEFEVERDA 2190

  Fly  4185 RGRG-GNSSASSGMQP---PPAHQHASLSRQSSGQFSKPAVPAMKTPPPSMGAPMDLSSSLPKMN 4245
            :.|| ...||:.|..|   ...|..:::....|.:.|           |...:|..:|:|.||:.
Human  2191 KARGLEQFSATHGHTPIILNGWHGESAMDLSCSSEGS-----------PGATSPFPVSASTPKIG 2244

  Fly  4246 MTEMLKSASSSGAIDLSEVQDFSM--PSKKSSVHAALSSAFPSMGNKSKLDDTLNKLMKKNNCTI 4308
            ....|:.|.   .:|||.:....:  |.....|:.:|           :.||...:
Human  2245 AISSLQGAL---GMDLSGILQAGLIHPVTGQIVNGSL-----------RRDDAATR--------- 2286

  Fly  4309 EEPVIGKEKKRKKLDEIVLGLSAAKEQKTFPDPSLPSSKKPQIPPSVSVTPANLQSSSNQQSNQK 4373
                  :.:.|:|..|..:.|...|||                         .||:.
Human  2287 ------RRRGRRKHVEGGMDLIFLKEQ-------------------------TLQAG-------- 2312

  Fly  4374 PFTITVTTVPGKSKSGSSNSGSGTGGSSSASGGGAGGSGLSALQNMAMGGLSSKDSLNALLAQTM 4438
              .:.|...||:: :.|:....|.|.::||.      ...:|..:.|...:.||..|:
Human  2313 --ILEVHEDPGQA-TLSTTHPEGPGPATSAP------EPATAASSQAEKSIPSKSLLD------- 2361

  Fly  4439 ATDPQTFLKQQQKMMQFLPPAQRKAYENMLAEMEQAMKISSKFSTNSPHDVKVNKWLSDMTSPLG 4503
                  :|:||
Human  2362 ------WLRQQ------------------------------------------------------ 2366

  Fly  4504 DQLSIDY---VGGGGASGSGSGNSRRSN-RQQGNSQQSSSAAQLQKQQQQQQQQQQQQQQHSMPG 4564
                .||   |.|.||:.|.....||.. ::.|....||
Human  2367 ----ADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSS-------------------------- 2401

  Fly  4565 PQNLTGEEPVPVINKQTGKRLGGNKAPQLKRLMQWLTENPNYEVDPKWLEQMQNPMSTPSPRPAS 4629
               |:|||.||.|.|:.|             |..:|.||           :..:.::.|..|
Human  2402 ---LSGEERVPAIPKEPG-------------LRGFLPEN-----------KFNHTLAEPILR--- 2436

  Fly  4630 MESGYGSSAVKSHGGRPLSNLSSTSSSSHTQQQSSAAQSQAGGNSGSSKKNSRQQTAASAALDQA 4694
                  .:..:..|.||.|.|        .:..|..|.|.:|  .|....|     ...|.:|..
Human  2437 ------DTGPRRRGRRPRSEL--------LKAPSIVADSPSG--MGPLFMN-----GLIAGMDLV 2480

  Fly  4695 ALQFGSLAGLNPSLLANLPGLGAFDPKNPLAAF----------DPKNPLLSMSFGGMPGMGNIPG 4749
            .||          .:.|:||:    |...|..|          :.....|||....:|||..:|
Human  2481 GLQ----------NMRNMPGI----PLTGLVGFPAGFATMPTGEEVKSTLSMLPMMLPGMAAVP- 2530

  Fly  4750 LGNLNNMNLFASLAGMGGLGNLAGMDTQSLAALMAAAGPTLGGLTGASGGAGSGKSQAQSQSSAT 4814
                       .:.|:|||          |:..||.                :..|.|.:..|:|
Human  2531 -----------QMFGVGGL----------LSPPMAT----------------TCTSTAPASLSST 2558

  Fly  4815 SSSSSASKKKQQQQQQQAQNEAAQLAAAISASTGGSGASGGKNAAASASQLAAGFPFLFP--NPS 4877
            :.|.:|..:|..:.:..:.:......|  ....|....|.....|.:.|...|..|||.|  :|.
Human  2559 TKSGTAVTEKTAEDKPSSHDVKTDTLA--EDKPGPGPFSDQSEPAITTSSPVAFNPFLIPGVSPG 2621

  Fly  4878 LLYPPMGLGGLNPYSLGSSGLGSAYDQLAQ-QYNLLNGATSSASNTSSTQSKSHQSQSKSSQS-- 4939
            |:||.|.|         |.|:|.|...:.| :::.:.|..|.......|:..:..|..:.:.|
Human  2622 LIYPSMFL---------SPGMGMALPAMQQARHSEIVGLESQKRKKKKTKGDNPNSHPEPAPSCE 2677

  Fly  4940 RNTTASANSAASLMNAMASMGGGASTVTTPSTSASGSGRGRQSSSRNQS 4988
            |..:...|.|.......|....||.           :|.|....|.|.:
Human  2678 REPSGDENCAEPSAPLPAEREHGAQ-----------AGEGALKDSNNDT 2715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	100/394 (25%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	32/66 (48%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	30/57 (53%)
		PLN03142	2029..>2606	CDD:215601	409/578 (71%)
		PTZ00341	<3662..3887	CDD:173534	52/278 (19%)
		BRK	4568..4611	CDD:462196	13/42 (31%)
CHD6	XP_016883588.1	PTZ00449	<105..374	CDD:185628	82/292 (28%)
		CD1_tandem_CHD5-9_like	289..354	CDD:349315	32/67 (48%)
		CD2_tandem_CHD5-9_like	373..431	CDD:349310	30/57 (53%)
		PLN03142	461..>986	CDD:215601	375/525 (71%)
		DEXHc_CHD6	462..683	CDD:350816	146/220 (66%)
		PHA03247	<2320..2694	CDD:223021	113/591 (19%)
		BRK	2403..2438	CDD:470653	14/67 (21%)