DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and ZRANB3

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_115519.2 Gene:ZRANB3 / 84083 HGNCID:25249 Length:1079 Species:Homo sapiens


Alignment Length:838 Identity:195/838 - (23%)
Similarity:320/838 - (38%) Gaps:211/838 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  2029 LRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQ 2093
            |.|:|.:|   :.|:......|::|||||||||||::..   .|.|....|.|::.|.|....|.
Human    37 LLPFQKDG---IIFALKRNGRCMVADEMGLGKTIQAIGI---TYFYKEEWPLLIVVPSSLRYPWT 95

  Fly  2094 REFEGW------TDMNVVVYHGSV----TSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMI 2148
            .|.|.|      .::||:.....|    |||..:..|.                   |:|.....
Human    96 EEIEKWIPELSPEEINVIQNKTDVRRMSTSKVTVLGYG-------------------LLTADAKT 141

  Fly  2149 VTDYMDLKAFNWRLCVIDEAHRLKNRNC---KLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLN 2210
            :.|.::.:  |:::.::||:|.:|:||.   ::|..:.| .....:||:|||......|||..:.
Human   142 LIDALNNQ--NFKVVIVDESHYMKSRNATRSRILLPIVQ-KARRAILLTGTPALGRPEELFMQIE 203

  Fly  2211 FLEPSQFSSQEEFMSE--------FG-----SLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPK 2262
            .|.|.:|....::...        ||     ..|....:|:|..||..:|:||||.:|...|.||
Human   204 ALFPQKFGRWTDYAKRYCNAHIRYFGKRPQWDCRGASNLNELHQLLSDIMIRRLKTEVLTQLPPK 268

  Fly  2263 EETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQ 2327
            ....|..:|.:...|      |.|.|| ::.......||                  :||.|.:.
Human   269 VRQRIPFDLPSAAAK------ELNTSF-EEWEKIMRTPN------------------SGAMETVM 308

  Fly  2328 YDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYP 2392
                   |.....:.:..|..||  .:.|.:...|:.:..:.|:|:..:..|....:.::..|..
Human   309 -------GLITRMFKQTAIAKAG--AVKDYIKMMLQNDSLKFLVFAHHLSMLQACTEAVIENKTR 364

  Fly  2393 FERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQ 2457
            :.||||.:..:.|...::::.|....| |.:|..:|.|.|:..|||..|:..:..|:|.:..||:
Human   365 YIRIDGSVSSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAE 428

  Fly  2458 ARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIED 2522
            .|.|||||...|.|:.|:...|.:..|:...:.     ||.:......|.|:....:...||..|
Human   429 DRAHRIGQCSSVNIHYLIANGTLDTLMWGMLNR-----KAQVTGSTLNGRKEKIQAEEGDKEKWD 488

  Fly  2523 LLKKGAYGAVMDDDNAGDKFCEE------------DIDSIL---KRRTQVITMESEKGSTFSKAS 2572
            .|:   :......:::.::..:|            ||.|..   .::.|::| ..::...|.:.:
Human   489 FLQ---FAEAWTPNDSSEELRKEALFTHFEKEKQHDIRSFFVPQPKKRQLMT-SCDESKRFREEN 549

  Fly  2573 FAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLS-----------EPRRRTQIKRY 2626
            ...|        .||   ||.|.:..||.::....||:.|.|:           .|.:..||:..
Human   550 TVVS--------SDP---TKTAARDIIDYESDVEPETKRLKLAASEDHCSPSEETPSQSKQIRTP 603

  Fly  2627 GHEDVMEL-----------------------NSEESSNENSDEEGGIGLRS-------RRRKEKR 2661
            ..|.|.|.                       |||....|..:...|..:..       :.:.||.
Human   604 LVESVQEAKAQLTTPAFPVEGWQCSLCTYINNSELPYCEMCETPQGSAVMQIDSLNHIQDKNEKD 668

  Fly  2662 DRAREKKGNDEYIPR-ERDALAALGLEEIQYGNWA--KSECFKVEK--GLLSFGWGRWSELLELG 2721
            |..::.....:.|.. |:.|||     :.:.|..|  |.|..|:||  ||.|          :.|
Human   669 DSQKDTSKKVQTISDCEKQALA-----QSEPGQLADSKEETPKIEKEDGLTS----------QPG 718

  Fly  2722 QFKRGWRDVD---VEDCARIILLYC-------LQVYKGDEK----------IKTFIWD 2759
              ...|:..|   |.|    .|::|       :.:|..|.|          ||..:|:
Human   719 --NEQWKSSDTLPVYD----TLMFCASRNTDRIHIYTKDGKQMSCNFIPLDIKLDLWE 770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171
PTZ00121 <1419..1923 CDD:173412
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310
PLN03142 2029..>2606 CDD:215601 149/617 (24%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
ZRANB3NP_115519.2 DEXHc_HARP_SMARCAL1 37..256 CDD:350768 65/246 (26%)
DNA annealing helicase activity 46..481 126/499 (25%)
DEAH box 157..160 2/2 (100%)
SF2_C_SNF 321..446 CDD:350180 36/127 (28%)
PIP-box 519..526 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..601 2/18 (11%)
zf-RanBP 625..647 CDD:395516 4/21 (19%)
RanBP2-type Zn finger 625..644 CDD:275376 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 689..725 14/52 (27%)
Endonuclease activity 1011..1079
HNHc <1011..1049 CDD:238038
APIM motif 1074..1078
Blue background indicates that the domain is not in the aligned region.

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