Protein Alignment kis and Rad54l2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_109655.2
• Gene: Rad54l2 / 81000
• MGIID: 1933196
• Length: 1467
• Species: Mus musculus
• Alignment Length: 1093
• Identity: 256/1093 - (23%)
• Similarity: 431/1093 - (39%)
• Gaps: 304/1093 - (27%)

  Fly  1734 SDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEK 1798
            |||.....|. ::|.:|...|:|.: ||:.|.|..||:.:..||....           :|.||.
Mouse     2 SDESASGSDP-DLDPDVELEDEEEE-EEEEEEVAVEEHDRDDEEGLLD-----------DTSLEG 53

  Fly  1799 M---EVDEKANDDQ-------SAVSKAEGSDE-----KSTDDSNPEEATTEK------NKESLEI 1842
            |   |..:...|.|       :..|::|.|::     |.....:|::...:|      |...|..
Mouse    54 MCGTEHAQLGEDGQRPPRCTSTTSSQSEPSEQLRHQGKILASEDPKKKRAQKPSHMRRNIRKLLR 118

  Fly  1843 EGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGD- 1906
            |.:.|.|.:..:..:.|..::.|...:....|:              ..:..|:..||.:|:..
Mouse   119 EDQLEPVTKAAQQEELERRKRLEQQRKEYAAPI--------------PTVPLEFLPEEIVLRASD 169

  Fly  1907 -----RRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSG-ETTKHYLV 1965
                 .||.|       ::...|:.....|||..::     |.|:::|      || |.|.|.:.
Mouse   170 GPQLPPRVLA-------QEVICLDSSSGSEDEKSSR-----DEVIELS------SGEEDTLHIVD 216

  Fly  1966 KWKSLPYEDCTWELEEDVD---NDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKG-- 2025
            ..:|:..||   |.||...   ||.:.|:....::.....       ||.     |:..|:..
Mouse   217 SSESVSEED---EEEEKGGTHVNDALNQHDALGRVLVNLN-------HPP-----EEENVFLAPQ 266

  Fly  2026 -GNSLRPYQLEGLNWL---------KFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPF 2080
             ..:::|:|:.|:.:|         :|...:...||||..||||||:|.::|:..::.:......
Mouse   267 LARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTV 331

  Fly  2081 LVIAPLSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKF------- 2138
            |.|.|::|:.||..||..|......:...|...:...:.::.:...:..|.:....|.
Mouse   332 LAIVPVNTLQNWLAEFNMWLPAPEALPADSKPEEVQPRFFKVHILNDEHKTVASRAKVTADWVSE 396

  Fly  2139 -NVLITTFEM---------IVTD------------YMDL----------KAFNWRLC-------V 2164
             .||:..:||         :.|.            .:||          :.|...||       :
Mouse   397 GGVLLMGYEMYRLLTLKKSLATSRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVI 461

  Fly  2165 IDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF-- 2227
            .||.||:||......:.|:.:....||:|:|.|||||:.|.:.:::|:.|....:::||.:.|
Mouse   462 CDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFER 526

  Fly  2228 ----GSL--RTEEEV-------NKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYY 2279
                |..  .|.::|       :.|.:||:..:.||....::..|..|||.:|.|.|:.||:..|
Mouse   527 PILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLY 591

  Fly  2280 RGILEQNFSFLKKGTTSANIPNL-MNTMMELRKCC---IHPYLL-------NGAEEQIQYDFKSQ 2333
            ...:::   |...||:..    | :|.:.....||   .||.:|       |.|.||   |...:
Mouse   592 TQFMDR---FRDCGTSGW----LGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQ---DLDVE 646

  Fly  2334 H------------------GED---PES------------------------------------- 2340
            .                  |||   |.|
Mouse   647 ELGSAGTSARCPPHGTKVKGEDSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKELLTN 711

  Fly  2341 YYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYP------------- 2392
            |...::.::.||||:..|:.:....|.::|:|||.:..|.::|::|..|..|
Mouse   712 YQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDMPCLPGAEGQGTQKW 776

  Fly  2393 -----FERIDGRIRGNLRQEAIDRYSKPGS-DRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQ 2451
                 :.|:||......|:..|::::.|.: ..::|||.|:||.||:||..|:.|:::|:.|||.
Mouse   777 VRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPC 841

  Fly  2452 NDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLS 2516
            :|.||..|.:|.||:|...||||:...|.|::::|:...|.|:...|:..:|..       ...:
Mouse   842 HDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPM-------LNFT 899

  Fly  2517 KKEIEDLL----KKGAYGAVMDDDNAGDKFCEEDIDSILK----RRTQVITMESEKGSTFSKASF 2573
            :||:|:||    |:.|....:  |..|.|      :|:|:    :...:||.|     .|...|.
Mouse   900 RKEVENLLHFVEKEPAPQTSL--DIKGIK------ESVLQLACLKYPHLITKE-----PFEHESL 951

  Fly  2574 AASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRY 2626
            ..  ||.|..:      ||..||      |.::...||...|.|..|....:|
Mouse   952 LL--NRKDHKL------TKAEKK------AAKKSYEEDKRTSVPYTRPSYAQY 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	44/215 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	10/72 (14%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	17/61 (28%)
		PLN03142	2029..>2606	CDD:215601	181/742 (24%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Rad54l2	NP_109655.2	HepA	110..890	CDD:440319	195/836 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..236		17/63 (27%)
		DEXHc_ARIP4	271..547	CDD:350827	64/275 (23%)
		DEAH box	463..466		2/2 (100%)
		LXXLL motif 1	551..555		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..671		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1046
		PHA03247	<1112..1445	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1213
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1282
		LXXLL motif 2	1329..1333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1445..1467