|
Fly 357 HHQQQQQQQQTQQQQQQSAPPYMSSSKHQQAAAQLNSSPQYRAPFPQLSPQMSPRPPTMSPHPQM 421
||....|..|.|.|:.::.| .|:.::..|..|..|...||| :|..||..|
Human 2 HHGTGPQNVQHQLQRSRACP----GSEGEEQPAHPNPPPSPAAPF---APSASPSAP-------- 51
Fly 422 SPRPVGVSPAKPPPPQQQQQQTQAQQPQQVVSNQPSQHSIQGMVGLPSPRPQPPTSGAGGAGAKG 486
|:.:.|.||:::..|:
Human 52 --------------------QSPSYQIQQLMNRSPA----------------------------- 67
Fly 487 PAPVAAPVN-TLQALEQMVMPSQALGLPPMDYPSAYRSAVGPRMPASPQQQQQQHQQWGAAHGAQ 550
....|| |||::..:|..:|.:.|.|:..||. ::.|.:..|.|::.: ||:.
Human 68 ---TGQNVNITLQSVGPVVGGNQQITLAPLPLPSP--TSPGFQFSAQPRRFE---------HGSP 118
Fly 551 HLAALQQQQAQQQQQQVQQQQQAPPQQQQQAAMLQAQQQHHQQQLSMYGQPMGQQPQTAQQQVVP 615
....:....:||.|.|...|....|.|..|.....|. |..:|
Human 119 SYIQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAP-----------GPGLG------------ 160
Fly 616 PVTSQPPV---VAASQQQQQQQHQQQSLNDQLQHSINDIVGG----GNSSGATGGAQNQHQQQPQ 673
:.|..|. |.||...: |.|::...|| .:.||.|..||. .|.|
Human 161 -LCSSSPTGGFVDASVLVR-------------QISLSPSSGGHFVFQDGSGLTQIAQG---AQVQ 208
Fly 674 LAAMSSPLHQQNLPNMHHLIQPTMETTQPTQQQQQTSQQQQQPQQPQATLTSPHHQQMQHQSPIH 738
|....:|: :.::::|.||..
Human 209 LQHPGTPI----------------------------TVRERRPSQPHT----------------- 228
Fly 739 QQQQSPHHQQHLPSYNQSQQQFDPFANILGDNQPAAS-----QQTMSPAH---------VSSPVP 789
|...:.|| ||...|||: |...||:| :||.:.
Human 229 QSGGTIHH--------------------LGPQSPAAAGGAGLQPLASPSHITTANLPPQISSIIQ 273
Fly 790 AQMQQQQHQTQQQPSQQVPQ----SQQQQVSQPQQ-------QTQQQQPSTPSHHLSSILNETAN 843
.|:.|||...|..| :|: .:...|..|.. .|....|::|| .||.
Human 274 GQLVQQQQVLQGPP---LPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSPS--------RTAV 327
Fly 844 SNDSSTLAVAANDSNNSSSNSSTNSIVNNQPTSVHDSNSQSSINSSSNNQQQLLMDNTNSHGGNS 908
....|:|.: .|..|:.:...|..:.: |..:|....|:.....:.|....
Human 328 PPGLSSLPL----------TSVGNTGMKKVPKKLEE------IPPASPEMAQMRKQCLDYHYQEM 376
Fly 909 ESAQNAGVD--VGLFDNNSMSSNSAAVAAVASNAASAAAALLDSNSQSSNAEFEKNQSEGEGLGV 971
::.:....: :.||.......|.....|......:...|.|..|......|.|:.:.|.|
Human 377 QALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEE---- 437
Fly 972 VEGVIANETDLPQDENSVSKTQDITLSTEL-----PTIQDDLQEKPTAEMEQTQLGQSLGDLSKS 1031
::::..||.. .|:..| .|::.||.:: :|......:.:.||
Human 438 -------KSEVINDEQQ-------ALAGSLVAGAGSTVETDLFKR-----QQAMPSTGMAEQSK- 482
Fly 1032 LLEEPKTVEESGEDKSQSAPGVA---PPADPIIPVTQPPQQQMPPI--GMPMHPIAPGYEAQAQG 1091
.|:. |.|.. ||. |.||..:|: ||.||.. |||..|.|.....|.|.
Human 483 ---RPRL--EVGHQ------GVVFQHPGADAGVPL----QQLMPTAQGGMPPTPQAAQLAGQRQS 532
Fly 1092 QGHMPPMM-PPYGGAPGMYPPYPMLHQQEIAALQQQIQELYCMPPGHELQHQDKLMRMQERLNLL 1155
|....|.. ||...|..::.|.|.|..: :||
Human 533 QQQYDPSTGPPVQNAASLHTPLPQLPGR--------------LPP-------------------- 563
Fly 1156 TQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKK 1220
||.|...|...: |..:.|||
Human 564 ---------AGVPTAALSSAL--------------QFAQQPQV---------------------- 583
Fly 1221 GEKAQVGQQQDLMDISGNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLS 1285
.:||...|..:.....||.:.|. |::|||:......|.|......|.::.. :
Human 584 -VEAQTQLQIPVKTQQPNVPIPAP------PSSQLPIPPSQPAQLALHVPTPGKVQVQ------A 635
Fly 1286 QDVHSANELDTSTDGSGKKKKPRKPRTPKDPNKP-PRDRTPKAKKPKDPNDPNSTETPAAVKKRA 1349
..:.|..::..|| |.|.||..| || |...:||.:
Human 636 SQLSSLPQMVAST------------RLPVDPAPPCPR-----------PLPTSSTSS-------- 669
Fly 1350 GASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIP 1414
|.|.:||..|.:...|. ||::
Human 670 ----------------------------LAPVSGSGPGPSPARSS--------------PVNR-- 690
Fly 1415 RGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAK 1479
|.||.:.|.:|
Human 691 --------------------PSSATNKALSP---------------------------------- 701
Fly 1480 ALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDEN 1544
...|||.
Human 702 --------------------VTSRTPG-------------------------------------- 708
Fly 1545 SLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSST 1609
:|||...|.:.|:.||::|. |::|:. |.|...||
Human 709 --VVASAPTKPQSPAQNATSSQ----------------DSSQDT--------LTEQITLE----- 742
Fly 1610 SAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPK-EKAPEPK 1673
|.|: ..:.:|..|....:|.| || ::||.||
Human 743 -----------------------NQVH-------QRIAELRKAGLWSQRRL----PKLQEAPRPK 773
Fly 1674 Q--DEEKSELDEATTDKPE-------------------GDEKFKTEGESKKDLTDSEETKLE--- 1714
. |....|:....||..: .:||...|...||: |:::|.
Human 774 SHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKE----EQSRLRRIA 834
Fly 1715 -SSAMEVD---SKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPE-----EQSETVKTEE 1770
|:|.|:: |..|...:...:.:.:.|.|..:.: .:|.:..||.:|: ::|.. :
Human 835 ASTAREIECFWSNIEQVVEIKLRVELEEKRKKALNL-QKVSRRGKELRPKGFDALQESSL----D 894
Fly 1771 NSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKA---------------EGSDE 1820
:..:..:.|:|..||.|...:.|..:|:.|.:|...|.|:.:|.. ||:..
Human 895 SGMSGRKRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFL 959
Fly 1821 KSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVK 1885
.|:....|: .:||::..:|:.:....|.|::.:.|.|| ..|:
Human 960 PSSQWPRPK--------------------PDGEDTSGEEDADDCPGDRESRKDLVLID--SLFI- 1001
Fly 1886 YRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSV 1950
..|.|.::::|| .:|..:|..:|..|.:
Human 1002 -----------------------------MDQFKAAERMNI-----GKPNAKDIADVTAVAE--- 1029
Fly 1951 HTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWK 2015
..|| ..:.::...::||. |.|
Human 1030 -----------------AILP-----------KGSARVTTSVKFNA--------------PSL-- 1050
Fly 2016 KLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLT-FVHSVYEYGIRGP 2079
:| .:||.||..||:||...:....|.|||||.|||||:|.:. |.|.....|..||
Human 1051 ------LY---GALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGP 1106
Fly 2080 FLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTS-KQMIQDYEYYYKTESGKVLKEPIKFNVLI 2142
.||:.....|..|:.|.:.| ..:.::.|.||... |...|:: .||..|:|.|
Human 1107 HLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEW------------AEPNSFHVCI 1159
Fly 2143 TTFEMIVTDYMDLKAF---NWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISE 2204
|::... :..|.|| .|:..||||..|:|....:..|.:..|..:.|:||..:||.|...|
Human 1160 TSYTQF---FRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLE 1221
Fly 2205 LFSLLNFLEPS----QFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEET 2265
|:::::||.|. ..||.....||.......:.|.:|..:.:|.:|||.|.||||.|..|.|.
Human 1222 LWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEH 1286
Fly 2266 IIEVELTNIQKKYYRGILEQNFSFLKKGT----TSANIPNLMNTMMELRKCCIHPYL-------- 2318
:::..|:|.||..|..:: |:.|| .|.:..|:::.::.|::.|.||.|
Human 1287 VLKCRLSNRQKALYEDVI------LQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPGS 1345
Fly 2319 ---------------------------------LNGAEEQI------------------------ 2326
|.|.|.:|
Human 1346 SYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTS 1410
Fly 2327 ---------------------QYD---------FKSQH--------------------------- 2334
||. |.|.|
Human 1411 AAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATF 1475
Fly 2335 ----------------------------------------------------------------- 2334
Human 1476 SANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPS 1540
Fly 2335 ------------------------GE------------------DPES----------------- 2340
|| .||:
Human 1541 HAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQ 1605
Fly 2341 ----------------------------------------------------------------- 2340
Human 1606 LRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTP 1670
Fly 2341 ------------------------------------------------------------YYKNL 2345
|.::|
Human 1671 QVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDL 1735
Fly 2346 I---------------------------------------------------------------- 2346
:
Human 1736 LRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIP 1800
Fly 2347 ----------------------------------------------------------LSAGKMV 2353
..:||:.
Human 1801 PVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLE 1865
Fly 2354 LIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSD 2418
.:..||.|||:.|.||||.|||:..|||||.:|.:....:.|||.......|||.:..::: |
Human 1866 ALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNR---D 1927
Fly 2419 RFVF--LLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYE 2481
|.:| :|.|.:...||||..||||:.||:|.||..|.:||..|.|||:.|.:.||||:..|:.|
Human 1928 RRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIE 1992
Fly 2482 REMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAG------- 2539
.::....: |.:::.:..||: |.:...|:::.|::|.: .|..: |:||
Human 1993 EKLLKNGT------KDLIREVAAQGN-DYSMAFLTQRTIQELFE--VYSPM---DDAGFPVKAEE 2045
Fly 2540 ----------------------------DKFCEEDI-----DSILKRRTQVITMESEKGSTFSKA 2571
.::.|||. :.:|...|..::.:||......:.
Human 2046 FVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEP 2110
Fly 2572 S-------------------------FAAS------GNRSDITIDDPDFWTKWAKKVDIDPDA-- 2603
| |..| .|..|..:.....|..|..|...:.:|
Human 2111 SQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARL 2175
Fly 2604 -CERDETEDLVLSEPRRRTQIKRYGHED------VMEL-NSEESSNENSD--------------- 2645
.|::|.| :|:..|.......|.:|| ||.| .......::||
Human 2176 RLEQEEAE--LLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATP 2238
Fly 2646 ----EEGGIGLRSRRRKEKRD------RAREKKGNDEYIPRERDALAALGLEEI-QYGNWAKSEC 2699
:...:.:|..|::.|.| :.:::.|.....||.....|..||.:| :.|...|...
Human 2239 IPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNI 2303
Fly 2700 F-----------------KVEKG------LLSFGWG---RWSELLEL--------GQFKRGWRDV 2730
. ..|.| |:|..|. ...:|||| ......|
Human 2304 LLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNW--- 2365
Fly 2731 DVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGE---------VQKISRDHSGLH------ 2780
|....::..|.::|:..::.:....::|.|.|:|: .|..::|.:..|
Human 2366 ---DLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTS 2427
Fly 2781 --NLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGS---DKDSGGINASAVA 2840
:|: |.:.|..:|......|.|.....|.|.|...:.. ||....|..:::.
Human 2428 HFDLM----------KMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLR 2482
Fly 2841 AAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNT 2905
| ...:|::|..|| ||.....
Human 2483 A--------ERIAKEKKALAD-------------------------------------QQKAQQP 2502
Fly 2906 PISELP---IRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAA 2967
.:::.| .:|||.|.|.| |.|......|:...
Human 2503 AVAQPPPPQPQPPPPPQQPP-------------------------------PPLPQPQAAGSQPP 2536
Fly 2968 GDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSS 3032
....||...|..:.....:............|| ..|..:..|..|.|: :|.|..
Human 2537 AGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITT---GGSAAVLAGTIKTSV--------TGTSMP 2590
Fly 3033 ENASGGN--DKTESENDATTVSESSYK--SEVLPG----KGSDLDVSV--------AQQDALSAT 3081
..|..|| ..|.:...|.|....:.: |.|.|| .|......| |.....:||
Human 2591 TGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATAT 2655
Fly 3082 PELANTSDPKMNKNDAQVSASVSC--------DPADSSSPEAAGKAQGTGVQ----TGDAGELDI 3134
|:|.:.:..:..:....|:||... .||.|..|:. :|.|||| |.......:
Human 2656 PDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQV---SQATGVQLPGKTITPAHFQL 2717
Fly 3135 ----------------------ESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKT----- 3172
:.:::..::.|..|....|.::.:..|.|..:|.|..|
Human 2718 LRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLI 2782
Fly 3173 ------------------ESCTNNATTNISTTTT---------TTTIT--------NTTTTTNNP 3202
:|.....|..:...|: .||:| ..||..|..
Human 2783 KMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQ 2847
Fly 3203 SSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAY-- 3265
.::......:...|.........:...||.:.|| |.:|..|....|.:..|...:..:..|.
Human 2848 VARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPP-VVSVPAAVVSSPGVTTLPMNVAGISVAIGQ 2911
Fly 3266 -----------QRNYKKEELKLQQKA--------------------KLQALVSSTP--------- 3290
|..:.::.|||:|:| |:.|...:||
Human 2912 PQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYA 2976
Fly 3291 -----PLSVPTTPT--------LQSMQMQLQSGSGSGGSGIGSSAQHDASGRSLQALMQ-SQGAS 3341
.....|||. .|.:|.|:|... :....|......|:|.:.. ||.||
Human 2977 AQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAK------LPQVVQQQTPVASIQQVASASQQAS 3035
Fly 3342 TSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADI 3380
....|...|::|| .||.| :||:...|.:
Human 3036 PQTVALTQATAAG------QQVQM-----IPAVTATAQV 3063
| 
