DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and SMARCAD1

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_001121901.1 Gene:SMARCAD1 / 56916 HGNCID:18398 Length:1028 Species:Homo sapiens


Alignment Length:1125 Identity:300/1125 - (26%)
Similarity:487/1125 - (43%) Gaps:269/1125 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1553 KKDKKPSANASNSNAG--SDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEK 1615
            |.::.|.|....|..|  |.:..:..:..|||:.:      ::|.|..:.::....||.....:.
Human    16 KIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVS------RANTPDSDITEKTEDSSVPETPDN 74

  Fly  1616 ERQ----------------ISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDK 1664
            ||:                :|:|:.:....:..|.|...|.::|::::                 
Human    75 ERKASISYFKNQRGIQYIDLSSDSEDVVSPNCSNTVQEKTFNKDTVII----------------- 122

  Fly  1665 PKEKAPEPKQDEEK-------------SELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESS 1716
                ..||.:|||.             |||::.:..:...|.|.:|..|.....:|::..||..|
Human   123 ----VSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKLIES 183

  Fly  1717 AMEVDS---------------------KEESEP-DDSKKSDEDNKDKDKMEVDDEVGKSDKESKP 1759
            ...:|.                     ...||| ::.:.:|:.:..|.:::..:|..:|.:.|..
Human   184 TSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSN 248

  Fly  1760 EEQSETV--KTEENSKAIEEDKSSTVLTADHAKEPE----TVLEKMEVDEKANDDQSAVSKAE-- 1816
            .|:.|::  |.::.....::.:...||     ||.|    ..||.::|..: :.|...||::|  
Human   249 WEKQESIVLKLQKEFPNFDKQELREVL-----KEHEWMYTEALESLKVFAE-DQDMQYVSQSEVP 307

  Fly  1817 -GSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKEN--DEKTEADMENKPEPVFID 1878
             |.:..|...:.|:.||..|.|:..              |:|.:|  ::|.:.::.| |:.| ::
Human   308 NGKEVSSRSQNYPKNATKTKLKQKF--------------SMKAQNGFNKKRKKNVFN-PKRV-VE 356

  Fly  1879 VEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRF---------------QQKQSQQLNIFE 1928
            ..||.......|.|..::.:.||:::...:  .||..|               .||::|::.   
Human   357 DSEYDSGSDVGSSLDEDYSSGEEVMEDGYK--GKILHFLQDASIGELTLIPQCSQKKAQKIT--- 416

  Fly  1929 NIEDEPFNQ---DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELE---------- 1980
              |..|||.   .||::.:...:|                       ||..|..:          
Human   417 --ELRPFNSWEALFTKMSKTNGLS-----------------------EDLIWHCKTLIQERDVVI 456

  Fly  1981 ------EDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNW 2039
                  ||:.|...:|.....  .....|            .:|:..:.....||:|||..||||
Human   457 RLMNKCEDISNKLTKQVTMLT--GNGGGW------------NIEQPSILNQSLSLKPYQKVGLNW 507

  Fly  2040 LKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGW-TDMN 2103
            |.....:..|.|||||||||||||::.|:..:|:.|..||.|::.|.|||.||.||...| ..:.
Human   508 LALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLK 572

  Fly  2104 VVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRL----CV 2164
            |:.|:||...::.|: :..:.:.|.         :||::||:...::...|...|. ||    .:
Human   573 VLCYYGSQEERKQIR-FNIHSRYED---------YNVIVTTYNCAISSSDDRSLFR-RLKLNYAI 626

  Fly  2165 IDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS 2229
            .||.|.|||......:.|..:|..:|:||:|||:|||:.||.|||||:.|..|||....:....|
Human   627 FDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFS 691

  Fly  2230 LRT----------EEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILE 2284
            .:|          :|.:...:.::||.:|||:|::|.|.|.||::.|....::..|::.|.|:  
Human   692 SKTKSADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGL-- 754

  Fly  2285 QNFSFLKKG----TTSANIPNLMNTMMELRKCCIHP------YLLNGAEEQIQYDFKS-QHGE-D 2337
              |:.|||.    .|..| ..:.|.||:|||...||      |.....:|..|...|. .|.| :
Human   755 --FNRLKKSINNLVTEKN-TEMCNVMMQLRKMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCEAN 816

  Fly  2338 PESYYK---------------------------NLILSAGKMVLIDKLLPKLKANGHRVLIFSQM 2375
            |:..::                           :|||.:||..::..:|.:||..|.||::|||.
Human   817 PDLIFEDMEVMTDFELHVLCKQYRHINNFQLDMDLILDSGKFRVLGCILSELKQKGDRVVLFSQF 881

  Fly  2376 VRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADT 2440
            ...|||||..|.:.::.:.|:||:.:.:.|...||.:: ...|.|||||.|||||||||||:|:.
Human   882 TMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFN-TDMDIFVFLLSTKAGGLGINLTSANV 945

  Fly  2441 VIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQ 2505
            ||::|.|.||.||.||:.||||:||.|.|.:.:|:.:.|.|..|......||.|:    |.|.| 
Human   946 VILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLE----QDMTT- 1005

  Fly  2506 GSKDGNNKQLSKKEIEDLLK 2525
              .|..::.....:|..|||
Human  1006 --VDEGDEGSMPADIATLLK 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171
PTZ00121 <1419..1923 CDD:173412 86/448 (19%)
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315 16/83 (19%)
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 10/76 (13%)
PLN03142 2029..>2606 CDD:215601 196/551 (36%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
SMARCAD1NP_001121901.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..82 15/71 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..251 8/47 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..328 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..373 5/19 (26%)
HepA <496..999 CDD:440319 188/519 (36%)
DEGH box 628..631 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000255 721..738 8/16 (50%)
DEGD box 1007..1010 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

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