Protein Alignment kis and smarcad1b

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_005155692.3
• Gene: smarcad1b / 563175
• ZFINID: ZDB-GENE-091113-61
• Length: 955
• Species: Danio rerio
• Alignment Length: 1104
• Identity: 297/1104 - (26%)
• Similarity: 470/1104 - (42%)
• Gaps: 250/1104 - (22%)

  Fly  1498 DDTLDRTPPPSPP---------PDSEMDSNKR---------RSSRNTQRKKYIDDVMLRFSDDEN 1544
            |..:..||....|         .||:.||:..         |..|..:||..........||:|.
Zfish    21 DSVIPETPETKRPSGSSLSTAISDSDSDSDSEISGSSMMPVRKLRPRKRKAASSADEYSVSDEEE 85

  Fly  1545 SLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSST 1609
            .::    ||..::|:.:.:..   |..::.:|   |...|::.|.:.....||..|....|.|
Zfish    86 EIV----VKTKRRPTHSRTTR---STSQQAQP---AHQKASETVTDIAHPSPLKTSGMAAADS-- 138

  Fly  1610 SAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQ 1674
              |.::.||....::..:.|.|...|......|:.       ..|...:|.:|.|.:.|.|...:
Zfish   139 --VQQRRRQQMCGSSQESDSRKGGRVSAADDSEEE-------GQRSKDQERMLRKLQRKFPHLNK 194

  Fly  1675 DEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNK 1739
            :|.:..|.|...                  |.|.   .||:..|..|...|||.|.|:.|.....
Zfish   195 NELRDVLQEHDW------------------LIDD---ALETLRMFSDLVVESEDDSSQTSTPAKH 238

  Fly  1740 DKDKMEV--DDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEK---M 1799
            .:...|.  ..:|.|.....||:.          |:.::..::|..:    ||:|  :|.|   :
Zfish   239 TRRVAETRPQAQVTKLSSPPKPKP----------SRPLDGTRTSQRI----AKQP--ILAKYTYV 287

  Fly  1800 EVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKE----GEESVKKEN 1860
            ..:|:.:|.:::|  ..|..:..:|.|   |.|..|.|..:....:...|.|    ...|:|
Zfish   288 SSEEECSDSEASV--VNGLLDSDSDQS---EETLSKLKTEILCFFQSASVDELTLIAGCSLK--- 344

  Fly  1861 DEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRV--AAKIRRFQQKQSQQ 1923
              |.:...|.:|...:.|:::...:....|         .|||.|.|.|  ..::.:....:.::
Zfish   345 --KAQKITELRPFKTWKDLDDAMRRRNGLS---------AELLAGCREVLKEREVVKGLMSKCEE 398

  Fly  1924 LNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKI 1988
            :::       ...||.|:|         .|:..|..|:
Zfish   399 ISV-------KLIQDVTQV---------MDKGPGSMTQ--------------------------- 420

  Fly  1989 EQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILA 2053
                                  ||:   |..|      ..|:||||.|||||.....|..:.|||
Zfish   421 ----------------------PEI---LSST------FQLKPYQLIGLNWLVLLHQNKLSGILA 454

  Fly  2054 DEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMI 2117
            ||||||||||:::|:..:|:.|..||.|:..|.||:.||.||...| ....|:||:||...::.:
Zfish   455 DEMGLGKTIQAISFLAHLYQEGNHGPHLITVPASTLDNWVRELNLWCPSFKVLVYYGSADDRKYM 519

  Fly  2118 QDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAF---NWRLCVIDEAHRLKNRNCKLL 2179
            : ||         :|.:.:::|::::|:.:.:.:..|...|   .....|.||.|.|||.|....
Zfish   520 R-YE---------ILNQIVEYNIIVSTYNLAIGNSSDRSLFCKLKLEYAVFDEGHLLKNMNSLRY 574

  Fly  2180 EGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEE--------V 2236
            ..|..:|.::|:||:|||||||:.||.|||||:.|:.|||....:::..|:::.||        :
Zfish   575 RHLMAINAKYRLLLTGTPLQNNLLELMSLLNFIMPNMFSSSTSQIAKMFSMKSSEEQSSFERDRI 639

  Fly  2237 NKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPN 2301
            ...:.::||.:|||:|.:|.|.|..|||.:....::..|::.|..:|.:     .|.:::.....
Zfish   640 THAKLIMKPFILRRVKSEVLKQLPAKEEQVEFCAMSERQQELYSALLHK-----LKHSSNGEKRE 699

  Fly  2302 LMNTMMELRKCCIHPYLLN--------GAEEQIQYDFKSQHGEDP-------------------- 2338
            |.|.||:|||...||.|..        .|..::.....|....||
Zfish   700 LTNVMMQLRKMSNHPLLHRQFYTTEKLKAMSKLMLKEPSHRDADPALIKEDMEVLSDFELHRLCQ 764

  Fly  2339 -----ESYYKN--LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERI 2396
                 ..|..|  ::|.:||:.|:.:||..||..|.||::|||....|||||.:|.:.|:.:.|:
Zfish   765 QYSALHEYQLNTDVLLDSGKLSLLTQLLNSLKEKGDRVVLFSQFTMMLDILEVFLRHHKHRYNRL 829

  Fly  2397 DGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCH 2461
            ||....:.|...||::: ...|.|||||.|:|||||||||:|:.||::|.|.||.||.||:.|||
Zfish   830 DGSTPMSDRIGLIDQFN-TDQDIFVFLLSTRAGGLGINLTSANVVILHDIDCNPYNDKQAEGRCH 893

  Fly  2462 RIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLK 2525
            |:||.|.||:.:|:.:::.|..|......||.|:    |.|.  .::||....| ..::..|||
Zfish   894 RVGQTKTVKVIKLISKDSIEDTMLRIGERKLKLE----QEMT--ATQDGEEDTL-PDDMTTLLK 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	1/1 (100%)
		PTZ00121	<1419..1923	CDD:173412	93/453 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	14/72 (19%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	7/57 (12%)
		PLN03142	2029..>2606	CDD:215601	193/544 (35%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarcad1b	XP_005155692.3	CUE	179..215	CDD:270465	12/56 (21%)
		ComEA	<329..377	CDD:441164	11/61 (18%)
		HepA	<429..926	CDD:440319	184/512 (36%)