Protein Alignment kis and chd4b

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_021322613.1
• Gene: chd4b / 560622
• ZFINID: ZDB-GENE-030131-4532
• Length: 1953
• Species: Danio rerio
• Alignment Length: 2278
• Identity: 601/2278 - (26%)
• Similarity: 916/2278 - (40%)
• Gaps: 647/2278 - (28%)

  Fly  1324 TPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKA-GSADG 1387
            |||:||.|.......:.|          |||:|...|          |:..:.|.|.:| ..|:|
Zfish    27 TPKSKKKKKAKKSRESRT----------SKRQKVIRE----------EIAVSSPEVMEAIRMAEG 71

  Fly  1388 EAETTSGGTGVDGESPDYDDIPVSKIPRGSNED---EKEAEAGDETVDSVPDSAGDPASTPSRRD 1449
            |.|                            ||   ..|:|..|              ..||::.
Zfish    72 EEE----------------------------EDRVMRSESEGSD--------------YAPSKKK 94

  Fly  1450 RKRSTA---RSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPP 1511
            :|||::   |.:.:|..:.|||..|:          ||:.     ||.:.|||
Zfish    95 KKRSSSSKDRKKGSAGEKAGGSGGKS----------KRKE-----PEPEEEDD------------ 132

  Fly  1512 DSEMDSNKRRSSRNTQRKKYIDDVMLRFS-DDENSLLVASPVKKDKKPSANASNSNAGSDVEKTE 1575
            |.:.|..:.:||........:.|:...|: :|.|||.......:..:|...|.|....  |.|..
Zfish   133 DDDDDGQEPKSSSQLLADWGMKDIDYTFTQEDYNSLTNYKAFSQFVRPLIAAKNPKIA--VSKMM 195

  Fly  1576 PQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQI-------------------ST 1621
            ...||:.      .|..:|.|:..|:...|:.:.:.||.....:                   :|
Zfish   196 MVLGAKW------REFSTNNPMRGSASANAALAAANVAAAVESMVTKVDAGGGGGPALATAPPTT 254

  Fly  1622 DAANAAMSSKPNYVYINTGDEDSMVVQLVLA-MRMGKRELILDKPKEKAPEPKQDEEKSELDEAT 1685
            .||..|....|         :....|.|..| .:.||......|.|   |.||..::||:..:..
Zfish   255 TAAPVAAPPPP---------QQPPAVPLRKAKTKEGKGPNARRKTK---PTPKPQDKKSKAKKVA 307

  Fly  1686 TDKPE-GDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDE 1749
            ..|.: |:.|.|.....::   |..|:..:|.::...|...|....:||: :.:|.|.||:.|.:
Zfish   308 PLKIKLGNFKRKRSSSGEE---DDGESDFDSFSVSDGSNSRSSRSKNKKA-KSSKKKKKMDEDAD 368

  Fly  1750 VGKSDKESKPE---EQSETVKTEENSKAIEEDKSSTVLTADHAKEPETV-----LEKMEVDEKAN 1806
            ..::|.:...|   :..|.:..:...:|..    ...|..|..:.||..     .||..:..:|.
Zfish   369 GYETDHQDYCEVCQQGGEIILCDTCPRAYH----MVCLDPDMERAPEGTWSCPHCEKEGIQWEAR 429

  Fly  1807 DDQSAVSKAEGSDEKSTDDSNPEEATTEKNKE--------------------------------- 1838
            ::.|     ||.:|  .||...::...|:..:
Zfish   430 EESS-----EGEEE--NDDGRRDDGDVEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHLHCLNPP 487

  Fly  1839 ---------------SLEIEGEKERV---KEGEE----SVKKENDEKTEADMENKPEPVFIDVE- 1880
                           |..::|:.::|   :.||.    .|.:..|...||.   .|.|:....|
Zfish   488 LPDIPNGEWICPRCLSPPLKGKVQKVLTWRWGEAPPPMPVPRPADLPAEAP---DPPPMIGRKER 549

  Fly  1881 EYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQ----LNI-FENIED-------- 1932
            |:|||:.|.||.||.|..|.:|   :.......|.:|:|...:    |.: .|..||
Zfish   550 EFFVKWCNKSYWHCSWVQELQL---ELNCQVMFRNYQRKTDMEEPPNLEMGAEGDEDKSCKRKNK 611

  Fly  1933 EPF-------------NQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVD 1984
            :||             ..::..:.|:|:.||     ..:...|||:||:.|||:..||| .||:|
Zfish   612 DPFYARMEDKYGRFGVKIEWLFIHRILNHSV-----DKKNNVHYLIKWRDLPYDQSTWE-SEDMD 670

  Fly  1985 NDKIEQY-------------------LRFNKIPQRSEWKSKKRPHPELWKKLEKTPVY--KGGNS 2028
            ....|.|                   .:..|:..|...:....|..:...|.::.|.|  ..|.:
Zfish   671 VPDFETYKQHYWNHRELMLGEEGRPGKKMKKVKVRKTERPPANPVVDPTIKFDRQPDYLDSTGGT 735

  Fly  2029 LRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFLVIAPLSTIPNW 2092
            |.||||||||||:|||....:.|||||||||||:|:..|::|:|:.| .:|||||.||||||.||
Zfish   736 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINW 800

  Fly  2093 QREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYK-------TESGKVLKE-PIKFNVLITTFEMI 2148
            :||||.|. ||.||.|.|...|:.:|::.|:.::       .::.|:.|| .:||:||:|::|:|
Zfish   801 EREFEMWAPDMYVVTYVGDKDSRAVIRENEFTFEDNAIRGGKKASKMKKEAAVKFHVLLTSYELI 865

  Fly  2149 VTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLE 2213
            ..|...|.:.:|...|:||||||||...|....|....|:|::||:|||||||:.|||.|||||.
Zfish   866 TIDQAILGSIDWACLVVDEAHRLKNNQSKFFRVLNNYPLQHKLLLTGTPLQNNLEELFHLLNFLT 930

  Fly  2214 PSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKY 2278
            |.:|::.|.|:.||..:..|:::.||..:|.|.||||||.||.|.:..|.|.|:.|||:.:||||
Zfish   931 PERFNNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKHMPSKTELIVRVELSPMQKKY 995

  Fly  2279 YRGILEQNFSFLK-KGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYY 2342
            |:.||.:||..|. :|  ..|..:|:|.:|:|:|||.||||...|        .::..:.|...|
Zfish   996 YKYILTRNFEALNTRG--GGNQVSLLNVVMDLKKCCNHPYLFPTA--------ATEAPKMPNGMY 1050

  Fly  2343 KN--LILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLR 2405
            ..  |..::||::|:.|:|.|||..||||||||||.:.||:|||:|....|.:|||||.:.|.:|
Zfish  1051 DGSALTKASGKLMLLFKMLKKLKEGGHRVLIFSQMTKMLDLLEDFLENEGYKYERIDGGVTGGMR 1115

  Fly  2406 QEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVK 2470
            ||||||::.||:.:|||||.|:||||||||..|||||||||||||.||:||.:|.|||||.|.|.
Zfish  1116 QEAIDRFNAPGAPQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVM 1180

  Fly  2471 IYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDD 2535
            |||.:.:.:.|..:...|..|:.|...|::.  ..|||.|:   :||:|::|:||.|......|:
Zfish  1181 IYRFVTKASVEERITQVAKKKMMLTHLVVRP--GLGSKAGS---MSKQELDDILKFGTEQLFKDE 1240

  Fly  2536 DNAGDKFCEED----------IDSILKRR------TQVITMESEKGSTFSKASFAASGNRSDITI 2584
            ...||. .|||          ||.:|.|.      |::.:| :|..|:|..|.:         .:
Zfish  1241 LGEGDN-KEEDSSVIHYDDKAIDRLLDRNQDATEDTELQSM-NEYLSSFKVAQY---------VV 1294

  Fly  2585 DDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHEDVMELNSEESSNENSDEEGG 2649
            .|.|     .::.|:|.:..:::|:.|     |....::.|:.:         |...|:.....|
Zfish  1295 KDED-----EEEEDVDREIIKQEESVD-----PDYWEKLLRHHY---------EQQQEDLARHLG 1340

  Fly  2650 IGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRW 2714
            .|.|.|:.....|.::|.:|:
Zfish  1341 KGKRPRKPVNYNDCSQEDRGS-------------------------------------------- 1361

  Fly  2715 SELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGL 2779
                     :|.|:|...::.:.    |.:...:|||       |....:|....::.||  .||
Zfish  1362 ---------RRDWQDDQSDNQSD----YSVASEEGDE-------DFDERSEAANSRRPSR--KGL 1404

  Fly  2780 HN-----LVP-RGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASA 2838
            .|     |.| ..|.||  |.|..|.:.....:...:......|...:.......:|..|.:...
Zfish  1405 RNDKDKPLPPLLARVGG--NIEVLGFNARQRKAFLNAVMRYGMPPQDAFTTQWLVRDLRGKSEKE 1467

  Fly  2839 VAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKD 2903
            ..|.|:..  ..|..:.....|:.:.:|..::.|.|  ..||.|:.::..|:.:     ||:.
Zfish  1468 FKAYVSLF--MRHLCEPGADGAETFADGVPREGLSR--QHVLTRIGVMSLIRKK-----VQEF-- 1521

  Fly  2904 NTPISELPIRPPPTPDQVPSSW---WNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAG 2965
                           :.|...|   |..                |:....||          .|.
Zfish  1522 ---------------EHVNGQWSMPWMK----------------ELEESKRA----------AAI 1545

  Fly  2966 AAGDDLAVTS----------LPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLD 3020
            |||:|....|          .|..||  .||.:|..|:::    .|:.....::.|...:|.::
Zfish  1546 AAGEDPKTPSTGTPADTQPNTPAPED--LSKTEDIKELEE----KTEGDGEKEVKGSRQEDEII- 1603

  Fly  3021 PERPSSSGKSSSENASGGNDKTESENDATTVSE-SSYKSEVLPGKGSDLDVSVAQQDALSATPEL 3084
             |.|....||.|  ::...:||:.|::|::..: .|.::|    |..:.:.|...::.:|
Zfish  1604 -EIPDEGEKSPS--SAKKEEKTDKESEASSEKDGGSRENE----KDGEKEKSAESKENMS----- 1656

  Fly  3085 ANTSDPKMNKNDA----------QVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKK 3139
               ||.|.:.:||          :.|:....|.:.:|..:...|.:..||:..|       |.|.
Zfish  1657 ---SDVKADGSDATNSGDSTKTKEESSEEKMDTSPASDEKKELKDEKDGVKPED-------SAKL 1711

  Fly  3140 DNEKETKESTGDAPAVEAKKDSAAIAR-----AEGDKTE--SCTNNATTNISTTTTTTTI----- 3192
            .|.:..||::|....|..:|..|...|     |:|..||  |...|.....:.|..|..|
Zfish  1712 QNGENAKETSGGGDGVSEEKKKAVKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRH 1776

  Fly  3193 -------------TNTTTTTNNPS----------------------------------------- 3203
                         .......|:|.
Zfish  1777 DYWLLAGIIFHGYARWQDVQNDPRFAILNEPFKGEMSRGNFLEIKNKFLARRFKLLEQALVIEEQ 1841

  Fly  3204 -SKAANSNNTTD--H---------------ANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPS 3250
             .:||..|.|.|  |               |.|:.||   .:||::|:.|
Zfish  1842 LRRAAYLNMTEDPSHPSMALNTRFSEVECLAESHQHL---SKESMSGNKP--------------- 1888

  Fly  3251 MQDLNTRLRRVITAYQRNYKKEELKLQQKA---KLQALVSSTPPLSVPTTPTLQSMQMQLQSGSG 3312
               .|..|.:|:.      :.|||....||   :|.|.::..||::|    .||..:..:.|...
Zfish  1889 ---ANAVLHKVLK------QLEELLSDMKADVTRLPATIARIPPVAV----RLQMSERSILSRLA 1940

  Fly  3313 SGG 3315
            |.|
Zfish  1941 SRG 1943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	42/182 (23%)
		PTZ00121	<1419..1923	CDD:173412	125/595 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	22/71 (31%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	20/76 (26%)
		PLN03142	2029..>2606	CDD:215601	271/605 (45%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
chd4b	XP_021322613.1	CHDNT	155..210	CDD:462357	15/62 (24%)
		PHD1_CHD_II	377..419	CDD:277006	7/45 (16%)
		PHD2_CHD_II	459..501	CDD:277007	0/41 (0%)
		CD1_tandem_CHD3-4_like	506..584	CDD:349314	24/83 (29%)
		CD2_tandem_CHD3-4_like	629..683	CDD:349309	20/59 (34%)
		PLN03142	734..>1274	CDD:215601	261/555 (47%)
		DEXHc_CHD4	736..967	CDD:350814	113/230 (49%)
		DUF1087	1308..1351	CDD:461922	10/56 (18%)
		CHDII_SANT-like	1397..1531	CDD:461920	31/163 (19%)
		PTZ00121	<1534..>1738	CDD:173412	54/258 (21%)
		CHDCT2	1769..1914	CDD:462358	25/171 (15%)