Protein Alignment kis and smarca1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001093467.1
• Gene: smarca1 / 559803
• ZFINID: ZDB-GENE-070705-296
• Length: 1036
• Species: Danio rerio
• Alignment Length: 1081
• Identity: 328/1081 - (30%)
• Similarity: 494/1081 - (45%)
• Gaps: 251/1081 - (23%)

  Fly  1818 SDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVE-- 1880
            |||:....|....|..|:..... :.|...:....|.....|.:||.:.|..|:.|.:....|
Zfish     2 SDEELPSTSREAHAEAEEEDPPF-LLGPPPKAVVKESLADPEYEEKRKTDRANRFEFLLKQTELF 65

  Fly  1881 EYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRV 1945
            .:|::       ....::....||      .|:.|.:.||.::.|:
Zfish    66 AHFIQ-------PASQKSPTSPLK------VKMGRPRIKQDEKQNL------------------- 98

  Fly  1946 LDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPH 2010
              :|| .|.....|                  |.|||                  .|..|:.|..
Zfish    99 --LSV-GDNRHRRT------------------EQEED------------------EELLSESRKA 124

  Fly  2011 PELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEY- 2074
            ..:..:.|::|.|....:||.||:.||||:...:.|..|.|||||||||||:|::..:..:..|
Zfish   125 DNVLVRFEESPSYIKNGTLRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTIALLGYLKHYR 189

  Fly  2075 GIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKE---P 2135
            .|.||.:|:.|.||:.||..||:.|. .:..|...|:              |.|....:::   |
Zfish   190 NIPGPHMVLVPKSTLHNWMNEFKRWVPTLKAVCLIGN--------------KDERAAFIRDVMMP 240

  Fly  2136 IKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQN 2200
            .:::|.:|::||::.:....|.||||..|||||||:||...||.|..|:....:|:||:||||||
Zfish   241 GEWDVCVTSYEMVIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIAREFKTTNRLLLTGTPLQN 305

  Fly  2201 NISELFSLLNFLEPSQFSSQEEFMSEFGS--LRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKE 2263
            |:.||:||||||.|..|:|..:|.|.|.:  |..::.|.:|.|:|:|.:|||:|.:|||||.||:
Zfish   306 NLHELWSLLNFLLPDVFNSASDFDSWFDTNCLGDQKLVERLHAVLRPFLLRRIKAEVEKSLPPKK 370

  Fly  2264 ETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQY 2328
            |..|.:.|:.:|:::|..||.::...|........: .|:|.:|:|||||.||||.:|||....|
Zfish   371 EVKIYLGLSKMQREWYTRILMKDIDILNSAGKMDKM-RLLNILMQLRKCCNHPYLFDGAEPGPPY 434

  Fly  2329 DFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPF 2393
            ...:           :|::::||||.:||||||::..|.||||||||.|.|||||||.::|.:.:
Zfish   435 TTDT-----------HLVINSGKMVALDKLLPKVQEQGSRVLIFSQMTRVLDILEDYCMWRGFEY 488

  Fly  2394 ERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQA 2458
            .|:||......|::|||.::.|.|.:|:|:|.|:||||||||..||.||:||||||||.||||..
Zfish   489 CRLDGNTPHEAREQAIDAFNAPNSSKFIFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMD 553

  Fly  2459 RCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDL 2523
            |.|||||||.||::||:..||.|..:.::|.|||.||..|:|    ||.......:|.|.|:..:
Zfish   554 RAHRIGQRKPVKVFRLITDNTVEERIVERAEMKLRLDSIVIQ----QGRLIDQQNKLGKDEMLQM 614

  Fly  2524 LKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKAS---FAASGNRSDITI- 2584
            ::.||.......|:   :..:||||:||:|..:.....:|:.....::|   |......::.::
Zfish   615 IRHGATHVFASKDS---ELTDEDIDTILERGAKKTAEMNERMQNLGESSLRNFTVDTGATETSLY 676

  Fly  2585 --DDPDFWTKWAKKVD-------------------------IDPDACERDET--------EDLVL 2614
              :..|:..|  :||.                         |:|...||...        |.|.:
Zfish   677 NFEGEDYREK--QKVGVFIFGHLIFVHIAVLKSINLSLIEWIEPPKRERKANYAVDAYFREALRV 739

  Fly  2615 SEPR----------------------------------RRT---------------QIKRYGHED 2630
            ||||                                  |:|               |:::.....
Zfish   740 SEPRAPKAPRPPKQPNIQDFQFFPPRLFELLEMEILYYRKTIGYKVPRSPDIPNSAQVQKEEQRK 804

  Fly  2631 VMELNSEESSNENSDEEGGIGLRSRRRKEKRD-----RAREKKGNDEYIPRERDALAALGLEEIQ 2690
            :.|  :|..|.|.::|:..:..:......|||     :|.||.|.|:.....|:.......|.::
Zfish   805 IDE--AEPLSPEETEEKEKLLTQGFTNWNKRDFNQFIKANEKYGRDDIDNIAREVEGKTPEEVME 867

  Fly  2691 YGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKT 2755
            |     |..|          |.|.:||               :|..:|:    .|:.:|:.:|:.
Zfish   868 Y-----SAVF----------WERCNEL---------------QDIEKIM----AQIERGEARIQR 898

  Fly  2756 FIWDLITPTEDGEVQKISRDHSGLHNL-VPRGRNGGKSNKE 2795
            .|  .|....|   .||:|..:..|.| :..|.|.||:..|
Zfish   899 RI--SIKKALD---VKIARYKAPFHQLRIQYGTNKGKNYTE 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	22/106 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	13/68 (19%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	8/57 (14%)
		PLN03142	2029..>2606	CDD:215601	240/614 (39%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarca1	NP_001093467.1	PLN03142	54..1033	CDD:215601	315/1028 (31%)