Protein Alignment kis and rad54l2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_005174062.1
• Gene: rad54l2 / 558947
• ZFINID: ZDB-GENE-030131-3097
• Length: 1455
• Species: Danio rerio
• Alignment Length: 1710
• Identity: 344/1710 - (20%)
• Similarity: 583/1710 - (34%)
• Gaps: 567/1710 - (33%)

  Fly  1659 ELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSK 1723
            |.|.....|.:...:::||:.|:||      |.:|..:.:|:.::|..|    :|||..|| |.:
Zfish    22 EAISGSDLEPSLNSEEEEEEEEMDE------EEEEDGENDGDDEEDAGD----QLESLEME-DRR 75

  Fly  1724 EESEP-DDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQ-SETVKTEENSKAIEEDKSSTVLTA 1786
            :.|.| ..|..|.:.:.::...........|...|:|..| ..:..|..|:.|....|..|..|:
Zfish    76 DPSSPAPTSPMSGDSSPERLSRPASRPSSTSRTSSRPGSQPPSSPDTRSNASANSNTKKKTSKTS 140

  Fly  1787 DHAKEPETVLE-----KMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEK 1846
            ..|.....:.:     ::|...||...:....:.....::.....:.:.||.        ..|.|
Zfish   141 KPAHLRRNIRKLLTENQLEAGTKAAQQEELERRRRLEQQRKEFSLHADLATA--------AAGSK 197

  Fly  1847 ERV----KEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDR 1907
            :.|    ..|:|..:||           .|.|...|..:..:                ||..||.
Zfish   198 QEVICLDSSGDEGEEKE-----------APPPPLPDHRDDVI----------------ELSSGDE 235

  Fly  1908 RVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPY 1972
            ..|.:|      .|::                 |.||  .::..|:|:||   .|.
Zfish   236 GDALRI------SSEE-----------------EEDR--SLTPGTEESSG---SHI--------- 263

  Fly  1973 EDCTWELEEDVDNDKIEQ-------YLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLR 2030
                        ||.:.|       .:..|              ||...:.|...|  :...:::
Zfish   264 ------------NDSLNQPDSQGRVLININ--------------HPAEEEDLFLAP--QLARAVK 300

  Fly  2031 PYQLEGLNWL------KFSWYNTHN---CILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPL 2086
            |:|:.|:.:|      ....|.|.:   ||||..||||||:|.::|:..:..:......|.|.|:
Zfish   301 PHQIGGIRFLYDNLVESLERYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPV 365

  Fly  2087 STIPNWQREFEGW----------TDMNVVV------------YHGSVTSKQMIQDYEYYYKTESG 2129
            :|:.||..||..|          ||...|:            :..:|...::::|:     |..|
Zfish   366 NTLQNWLAEFNLWLPAAEALPPDTDPQQVLPRTFKVHILNDEHKTTVARAKVVEDW-----TGDG 425

  Fly  2130 KVLKEPIKFNVLITTFEMIVT-----------------DYMD-----LKAFNWRL-------CVI 2165
            .||....:...|::..:..||                 |..|     :||....|       .:.
Zfish   426 GVLLMGYEMYRLLSLKKSFVTGRKRKSKKPAGPVIIDLDEEDRQQELMKAIERALSRPGPDVVIC 490

  Fly  2166 DEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF--- 2227
            ||.||:||.:....:.|:.:....||:|:|.|||||:.|.:.:::|:.|....:::||.:.|
Zfish   491 DEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERP 555

  Fly  2228 ---GSL--RTEEEV-------NKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYR 2280
               |..  .|.::|       :.|.:||:..:.||..|.:...|.||||.:|.|.|:.:|:..|.
Zfish   556 ILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRRGHDVLRHQLPPKEEHVILVRLSRLQRALYT 620

  Fly  2281 GILEQNFSFLKKGTTSANIPNL-MNTMMELRKCC---IHPYLL-------NGAEEQ--------- 2325
                   .|:.:...:.|...| :|.:.....||   .||.:|       |.|.||
Zfish   621 -------EFMNRFREAGNSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDLDDLNS 678

  Fly  2326 ---------------------------------------IQYDFKSQHGEDPESYYKNLILSAGK 2351
                                                   |.|::..   |...:|...::.::.|
Zfish   679 SSGTRCSAPGIKSKTSDAANSRQMSVGHLNPLQEKANQVITYEWAK---EVMTNYQTGVLENSAK 740

  Fly  2352 MVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFE---------------RIDGRIR 2401
            |||:..|:.:..|.|.::|:|||.:..|.::||:|..|..|.:               |:||...
Zfish   741 MVLLFYLIDETVARGDKILVFSQSLSTLTVIEDFLSRRPMPIQTETGTHNWVRNINYYRLDGSTS 805

  Fly  2402 GNLRQEAIDRYSKPGSDR-FVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQ 2465
            .:.|:..|::::.|.:.: :||||.|:||.||:||..|:.|:::|:.|||.:|.||..|.:|.||
Zfish   806 ASERERLINQFNDPANTQAWVFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQ 870

  Fly  2466 RKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYG 2530
            ||...||||:|..|.|::::|:...|.|:...|:..:|..       ...::||:|.||
Zfish   871 RKPCHIYRLVCDFTLEKKIYDRQVSKQGMSDRVVDDLNPV-------LNFTRKEVESLL------ 922

  Fly  2531 AVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAK 2595
                      .|.||                                        :||
Zfish   923 ----------HFVEE----------------------------------------EPD------- 930

  Fly  2596 KVDIDPDACERDETEDLV----------LSEPRRRTQIKRYGHEDVMELNSEESSNENSDEEGGI 2650
            ..::.|:    :|.|.::          |::|       .:.||.::....|....
Zfish   931 PAELQPN----NEMETVIQQACVMYPHLLTKP-------PFHHESLLMDRKEMKLT--------- 975

  Fly  2651 GLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWS 2715
              ::.:|..|:....||:.:   :|.:|.:.|       .|  :..|:                .
Zfish   976 --KAEKRAAKKSYEDEKRAS---VPYQRPSYA-------HY--YPASD----------------Q 1010

  Fly  2716 ELLELGQF-KRGWR---DVDVEDCARI-------ILLYCLQVYKGD------------EKIKTFI 2757
            .|..:..| :|.||   .::.:..|.:       |.:...||..|.            :|...::
Zfish  1011 RLTNIPAFSQRNWRPPPHLEEKPVASVRPVQSTPIPMMPRQVPMGVPSSSTGFPVNYLQKAGVYV 1075

  Fly  2758 ------WDLITPTEDGEVQKISRDHSGLHNLVPRGRNG-------GKSNKESTGVSTPAPGSASG 2809
                  .|::.|..:......:|..:|....|.||..|       |:.....:|...|..|.|:.
Zfish  1076 QRVVTTTDIVIPGSNSSTDVQARIGAGESIHVIRGSKGTYIRTNDGRIFAIRSGKPRPPEGGATA 1140

  Fly  2810 SNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGR 2874
            |......|.|..|....|.::...:...|:         |...|::..           :.|...
Zfish  1141 SREDCGPPLHSVSNGRASPQEPKRLTPEAL---------PRPSSRESP-----------RFHREF 1185

  Fly  2875 HANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVGT 2939
            |:||             |.:..........||.|....||...|..:|
Zfish  1186 HSNK-------------EAVASAENLTSSGTPESTGADRPIQHPSHLP----------------- 1220

  Fly  2940 YKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDS 3004
                 |.:||:..|             ....:.|.||.....::.:....|.:.....|:.....
Zfish  1221 -----EQHRQLSND-------------IASSVDVQSLKRKLLESRTSKQPGGKRTSTSTSAAGSY 1267

  Fly  3005 DSTKLTGGDNKDSL-LDPE--------RPSSSGKSSSENASGG-------------------NDK 3041
            ....|..|....|: |:|.        .|.|.|..|......|                   ::.
Zfish  1268 PGFPLNSGFGFPSMALNPALLGALGHVTPPSLGSRSHLMQQAGQTLGDLHAMFPTEPLGLGVSNS 1332

  Fly  3042 TESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCD 3106
            |.|...:|..:.||: |.:|....|.:..|.....:.|..|.:.|.|          :::.:|..
Zfish  1333 TLSSTCSTNTTSSSH-SGMLASSSSSVPSSSLSSTSSSLPPFMMNPS----------MASMLSGF 1386

  Fly  3107 PADSSSPEAAGKAQGTGVQT 3126
            |...|.|...|.....|:.:
Zfish  1387 PVPFSQPLFPGSLHPRGLSS 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	56/274 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	13/66 (20%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	11/64 (17%)
		PLN03142	2029..>2606	CDD:215601	174/726 (24%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
rad54l2	XP_005174062.1	HepA	<203..905	CDD:440319	192/808 (24%)
		DEXHc_ARIP4	299..575	CDD:350827	69/280 (25%)
		PHA03378	<929..1179	CDD:223065	51/315 (16%)