Protein Alignment kis and smarcad1a

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001018610.2
• Gene: smarcad1a / 557875
• ZFINID: ZDB-GENE-050522-499
• Length: 972
• Species: Danio rerio
• Alignment Length: 1115
• Identity: 316/1115 - (28%)
• Similarity: 486/1115 - (43%)
• Gaps: 256/1115 - (22%)

  Fly  1501 LDRTPPPSPPPDSEMDSNKRRSSRNTQ--------RKKYIDDVMLRFSDDENSLLVASPVKKDKK 1557
            :.|..|.....|.|   ||:...|...        .::.::||.   ||||        |.:..|
Zfish    19 IHRKSPDGSNSDKE---NKQAHQRKADGQFPSGKTSRQVLEDVS---SDDE--------VVRMGK 69

  Fly  1558 PSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTD 1622
            .||:....:...|:|....:       ..|:..:||...|     ||...:||.:         |
Zfish    70 DSASDLQQHINKDMEDKIIK-------LLEIFPQKSKKDL-----LEVIENTSTL---------D 113

  Fly  1623 AANAAMSSKPNYVYINTGDEDSMVVQLVLAMR--MGKRELILDKPKEKAPEPKQDEEKSELDEAT 1685
            .|.|       :..:..|||||       ..|  .|.|....|:||:|....:.|..:||.:::.
Zfish   114 GAVA-------HCLMIYGDEDS-------GGRKDKGGRSDDDDQPKKKRKIQRSDSSESEDEDSE 164

  Fly  1686 TDKPEGDEKFKTEG---ESKKDLTDSEETKLESSAMEVDSKEE---------SEPDDSKKSDEDN 1738
            .::.|...:.|.|.   :.|:.|.|.|:..|.....|.|...|         |..|.|  |.||.
Zfish   165 DEESEEPSREKQEALLKKLKRKLPDIEKEVLRDILKEHDWDYENALGSLLVFSSTDTS--SPEDQ 227

  Fly  1739 KDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDE 1803
            |.|.|.:......|:||.::....|.::              |..|||..:..||  :..|..
Zfish   228 KSKQKSKSSHSKEKTDKITQRPSGSSSL--------------SRWLTAASSHVPE--VSSMSA-- 274

  Fly  1804 KANDDQSAVSKA---EGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTE 1865
             ....:||:||:   ..|.::...|..|....:....|. ||:.:.:.:.:.::|   |:::...
Zfish   275 -LKTQKSALSKSTSKNSSFKRKRGDEMPLNDVSASEDED-EIDSDVDSMSDDQDS---EDEDSIS 334

  Fly  1866 ADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQS-QQLNIFEN 1929
            ..:::|           .:::...:.|     .|..|:.|     ..|::.|:..| :..|.:::
Zfish   335 GTLQDK-----------IIQFLQDASL-----DELALISG-----CSIKKAQKIISLRPFNTWKD 378

  Fly  1930 IEDEPFNQDFTEVDR-------------VLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEE 1981
            ::::.|..:...:|.             |||:....::.:.:.||            |.|..:|.
Zfish   379 VKEQFFKDNGLSIDLVHGCKVVLKERQVVLDLMGRCEKIAQKMTK------------DVTQVIEA 431

  Fly  1982 DVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYN 2046
            .:.:.|..:.|..|.                               .|:.|||.||.||.....:
Zfish   432 GMGSIKQPKVLNSNL-------------------------------KLQAYQLIGLKWLILLHQH 465

  Fly  2047 THNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGS 2110
            ..:.|||||||||||||::.|:..:||.||:||.|:..|.||:.||.||...| ..:.|::|:||
Zfish   466 KLSGILADEMGLGKTIQAIAFLAHLYEKGIKGPHLITVPSSTLDNWVRELGLWCPSLKVLIYYGS 530

  Fly  2111 VTSKQMI-QDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAF---NWRLCVIDEAHRL 2171
            |..::.: ||           :|...|.||::::|:.:.:.:..|...|   ..:..|.||.|.|
Zfish   531 VEDRKYLRQD-----------ILTGLIDFNIIVSTYNLTIGNDHDRSLFRKLKLKYAVFDEGHML 584

  Fly  2172 KNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEE- 2235
            ||.|......|..:|.|||:||:|||||||:.||.|||||:.||.|||....:|:..|.|:.||
Zfish   585 KNMNSLRYRHLMTINAEHRLLLTGTPLQNNLLELMSLLNFIMPSMFSSSTSQISKMFSTRSSEEE 649

  Fly  2236 -------VNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKG 2293
                   :.:.:.::||.:|||:|.:|.|.|.||.|.|....:::.|.|.| .||   |..|||
Zfish   650 SSFHKDRIAQARLIMKPFILRRVKSEVLKELPPKMEKIEMCPMSDAQHKLY-DIL---FKRLKK- 709

  Fly  2294 TTSANIPNLMNTMMELRKCCIHPYL------------LNGA--EEQIQYD--------------- 2329
            |.:.:...|.|.||:|||...||.|            ::.|  :|...||
Zfish   710 TPNGDKRELCNVMMQLRKMANHPLLHRQYYTSDKLAAMSKAMLKEPTHYDADPALIQEDMEVMSD 774

  Fly  2330 ---------FKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDY 2385
                     :.|..|...|   |.|||.:||..|:.|.|.|||..|.||::|||....|||:|..
Zfish   775 FELHNLCREYSSISGFQLE---KALILDSGKFALLTKTLAKLKEKGDRVVLFSQFTMMLDIVEIL 836

  Fly  2386 LVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNP 2450
            |.:..:.:.|:||......|...||:|: ...:.|||||.|:|||.||||.:|:|||::|.|.||
Zfish   837 LKHLDHQYVRLDGSTPMAERIGLIDKYN-TNPEIFVFLLSTRAGGQGINLASANTVILHDIDCNP 900

  Fly  2451 QNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQL 2515
            .||.||:.||||:||.:.|::.:|:.:::.|..|......||.|:    |.|.|...:||    .
Zfish   901 FNDKQAEDRCHRMGQTRTVQVIKLISKDSIEDCMLRVGQEKLKLE----QDMTTDEGEDG----A 957

  Fly  2516 SKKEIEDLLK 2525
            ..:::.:|||
Zfish   958 ITEQMAELLK 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	96/447 (21%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	8/66 (12%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	11/70 (16%)
		PLN03142	2029..>2606	CDD:215601	206/548 (38%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarcad1a	NP_001018610.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..76		17/70 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	125..177		16/58 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..333		32/140 (23%)
		ComEA	<348..>381	CDD:441164	8/42 (19%)
		HepA	<439..944	CDD:440319	199/555 (36%)
		DEGH box	579..582		2/2 (100%)