DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kis and CHD7

DIOPT Version :9

Sequence 1:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster
Sequence 2:	XP_011515855.1	Gene:	CHD7 / 55636	HGNCID:	20626	Length:	3027	Species:	Homo sapiens

Alignment Length:	4575	Identity:	1266/4575 - (27%)
Similarity:	1756/4575 - (38%)	Gaps:	1775/4575 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 PRMPASPQQQQQQHQQWGAAHGAQHLAALQQQQAQQQQQQVQQQQQAPPQQQQQAAM--LQAQQQ 589
            |..|.:|..||....|..|:                    :|.....|...|.|..:  .....|
Human    30 PENPVNPMGQQMPIDQGFAS--------------------LQPSLHHPSTNQNQTKLTHFDHYNQ 74

  Fly   590 HHQQQLSMYGQPMGQQPQTAQQQVVPPVTS--QPPVVAASQQQQQQQHQQQSLNDQLQHSINDIV 652
            :.||::.:..||......|....:..|.:.  .|||                  .|:.|
Human    75 YEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPV------------------PQVPH------ 115

  Fly   653 GGGNSSGATG---GAQNQHQQQPQLAAMSSPLHQQNLPNMHHLIQPTMETTQPTQQQQQTSQQQQ 714
             ||:..|..|   |.||:.             |.|:..:...:..| .....|.|.:....|||.
Human   116 -GGSGGGQMGVYPGMQNER-------------HGQSFVDSSSMWGP-RAVQVPDQIRAPYQQQQP 165

  Fly   715 QPQQPQATLTSP----HHQQMQHQSPI-----HQQQQSPHHQQHLPSYNQSQQQFDPFANILGDN 770
            |||.||...:.|    |.|.||.....     ...||....||.:..::|.|:         |.|
Human   166 QPQPPQPAPSGPPAQGHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQE---------GLN 221

  Fly   771 QPAASQQTMSPAHVSSPVPAQMQQQQHQTQQQPSQQVPQSQQQQVSQPQQQTQQQQPSTPSHHLS 835
            |......|..|.|:|           |..||.||  :..|.:..|.|     ....|||..|..|
Human   222 QGNPFIATSGPGHLS-----------HVPQQSPS--MAPSLRHSVQQ-----FHHHPSTALHGES 268

  Fly   836 SILNETANSNDSSTLAVAANDSNNSSSNSSTNSIVNNQPTSVHDSNSQSSINSSSNNQQQLLMDN 900
            ...:...:.|.....||.....|.||.:.:..|     || :::|...|....|:.||.  |::|
Human   269 VAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVPS-----PT-INNSGQYSRYPYSNLNQG--LVNN 325

  Fly   901 TNSHGGNSESAQNAGVDVGLFDNNSMSSNSAAVAAVASNAASAAAALLDSNSQSSNAEFEKNQSE 965
            |..:       ||    :||.:|..|:.:....    .||..     ..|||
Human   326 TGMN-------QN----LGLTNNTPMNQSVPRY----PNAVG-----FPSNS------------- 357

  Fly   966 GEGLGVVEGVIANETDLPQDENSVSKTQDITLSTELPTIQDDLQEKPTAEMEQTQLGQSLGDLSK 1030
            |:||                                              |.|..:..| |.|::
Human   358 GQGL----------------------------------------------MHQQPIHPS-GSLNQ 375

  Fly  1031 SLLEEPKTVEESGEDKSQSAPGVAPPADPIIPV-----TQPPQQQMPPIGMPM---------HPI 1081
            .   ..:|:..|....:.::|   ||..|:..:     |.|||.:....|:||         ||
Human   376 M---NTQTMHPSQPQGTYASP---PPMSPMKAMSNPAGTPPPQVRPGSAGIPMEVGSYPNMPHP- 433

  Fly  1082 APGYE---AQAQGQ-------------------------GHMPPMMPPYGGAPGMYPPYPMLHQQ 1118
            .|.::   |...||                         |||.|     .|.||:....|...|:
Human   434 QPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRP-----NGCPGVGLGDPQAIQE 493

  Fly  1119 EIAALQQ------QIQELYCMPP--GHE-LQHQDKLMRMQERLNLLTQHEVNDQCAGGPQCLLFQ 1174
            .:...||      ..|:|...||  .|. |.||.....        ..|:...|....||... |
Human   494 RLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPH--------PHHQPWAQLHPSPQNTP-Q 549

  Fly  1175 NVPPMYGPPGNPLLNQQMVESPQVSSTTGRGRGKSANKP---RKPRAKKGEKAQVGQQQDLMDIS 1236
            .||.....|..|.|.:.:.:..|||....:........|   ::|:.||.:|..
Human   550 KVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKN----------- 603

  Fly  1237 GNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTSTDGS 1301
                    |.:         |:|| .::|.|.....|.::..|         .:.|.||.|.:
Human   604 --------NHI---------VAED-PSKGFGKDDFPGGVDNQE---------LNRNSLDGSQE-- 639

  Fly  1302 GKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQT 1366
             :|||.::.:..|||.:|        |:||:..:|...:||.|
Human   640 -EKKKKKRSKAKKDPKEP--------KEPKEKKEPKEPKTPKA---------------------- 673

  Fly  1367 GEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETV 1431
                      |.:||.                               |:     ||:|:
Human   674 ----------PKIPKE-------------------------------PK-----EKKAK------ 686

  Fly  1432 DSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDG 1496
                      .:||..:..|:|   |.:..:||             |.||||:.|:|:    ::|
Human   687 ----------TATPKPKSSKKS---SNKKPDSE-------------ASALKKKVNKGK----TEG 721

  Fly  1497 -EDDTLDRTPPPSPPPDSEMDS--NKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKP 1558
             |:..||:||||||||:.:.|.  .||||||..:||:|.:|:..:.||:
Human   722 SENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDE---------------- 770

  Fly  1559 SANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDA 1623
                                  |.|.|...|.:                |.|..::.|:|.|.||
Human   771 ----------------------EADDADAAGRD----------------SPSNTSQSEQQESVDA 797

  Fly  1624 ANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDK 1688
                               :..||:.:::.|
Human   798 -------------------EGPVVEKIMSSR---------------------------------- 809

  Fly  1689 PEGDEKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKS 1753

Human   810 ----------------------------------------------------------------- 809

  Fly  1754 DKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGS 1818

Human   810 ----------------------------------------------------------------- 809

  Fly  1819 DEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYF 1883
                         :.:|.|||            |||                      :::||::
Human   810 -------------SVKKQKES------------GEE----------------------VEIEEFY 827

  Fly  1884 VKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDM 1948
            |||:|||||||:|.:.|:|.| |:|:..||:||:.||.|. .....||||.||.|:.||||::|.
Human   828 VKYKNFSYLHCQWASIEDLEK-DKRIQQKIKRFKAKQGQN-KFLSEIEDELFNPDYVEVDRIMDF 890

  Fly  1949 SVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRS-EWKSKKRPHPE 2012
            :..||: .||...||||||.||||||.|||..:|:|..|||:   |.|:..|. |.:..:||..:
Human   891 ARSTDD-RGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEE---FEKLMSREPETERVERPPAD 951

  Fly  2013 LWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIR 2077
            .|||.|.:..||..|.||.|||||:|||.|:|||..||||||||||||||||:||::.:|..||.
Human   952 DWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIH 1016

  Fly  2078 GPFLVIAPLSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLI 2142
            |||||||||||||||:|||..||::||||||||..|::.||.||.|:|...|:|:|...||:.:|
Human  1017 GPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAII 1081

  Fly  2143 TTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFS 2207
            ||||||:||..:|:...||..|||||||||||||||||||:.::|||:|||:||||||.:.||||
Human  1082 TTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFS 1146

  Fly  2208 LLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELT 2272
            ||:|||||:|.|:..||.|||.|:|||:|.||||:||||||||||:||||:||||||||||||||
Human  1147 LLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELT 1211

  Fly  2273 NIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQH-GE 2336
            ||||||||.|||:||:||.||...||:|||:||||||||||.||||:|||||:|..:||..| .|
Human  1212 NIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNAE 1276

  Fly  2337 DPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIR 2401
            .|:...:.:|.:|||:||||||||||||.|||||||||||||||||||||:.|:||:||||||:|
Human  1277 SPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVR 1341

  Fly  2402 GNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQR 2466
            |||||.||||:|||.||||||||||:|||||||||||||.||:|||||||||||||||||||||.
Human  1342 GNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQS 1406

  Fly  2467 KMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGA 2531
            |.||||||:.||:||||||||||:||||||||||||:.:.:.....:|||||||||||:||||||
Human  1407 KSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGA 1471

  Fly  2532 VMDDDNAGDKFCEEDIDSILKRRTQVITMESE-KGSTFSKASFAASGNRSDITIDDPDFWTKWAK 2595
            :||:::.|.||||||||.||.|||..||:||| |||||:||||.|||||:||::|||:||.||||
Human  1472 LMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAK 1536

  Fly  2596 KVDIDPDACERDETEDLVLSEPRRRTQIKRYG---HEDVMELNSEESSNENSDEEGGIGLRSRRR 2657
            |.::|.||.  :...:||:..||.|.|.:.|.   .:::||.:..||.:|...     ..:.||.
Human  1537 KAELDIDAL--NGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEKP-----CAKPRRP 1594

  Fly  2658 KEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQ 2722
            ::|..                              .:|:||||:|||.||.:|||||:::|..|:
Human  1595 QDKSQ------------------------------GYARSECFRVEKNLLVYGWGRWTDILSHGR 1629

  Fly  2723 FKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGR 2787
            :||...:.|||...|.||:|||..|||||.||:|||||||||.||:.:.:. :||||...|||||
Human  1630 YKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV-NHSGLSAPVPRGR 1693

  Fly  2788 NGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHW 2852
            .|.|...:||                       ...:..:|                       |
Human  1694 KGKKVKAQST-----------------------QPVVQDAD-----------------------W 1712

  Fly  2853 SKKEKYDADAYLEGAYKKHLGRHANK------------------------------VLLRVRMLY 2887
            ......|| .:.|.:|||||..|.|.                              |||||||||
Human  1713 LASCNPDA-LFQEDSYKKHLKHHCNNSGNNATDQLYVLASCDLEQVIQPLEDSLSWVLLRVRMLY 1776

  Fly  2888 YIQHEVIGDFVQQIKDNTPISELPI-RPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMR 2951
            |::.|||||...:|.:....||..: .|.|...:||:.||:.. .|||||:|.:|||.|.|..||
Human  1777 YLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKE-ADKSLLIGVFKHGYEKYNSMR 1840

  Fly  2952 ADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKD 3016
            |||.|||:..||   ..|..|:.:                  :..||....|       |||
Human  1841 ADPALCFLERVG---MPDAKAIAA------------------EQRGTDMLAD-------GGD--- 1874

  Fly  3017 SLLDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDALSAT 3081
                                ||....|.|:.....:.:.:|.|:
Human  1875 --------------------GGEFDREDEDPEYKPTRTPFKDEI--------------------- 1898

  Fly  3082 PELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNEKETK 3146
            .|.||:                   |::
Human  1899 DEFANS-------------------PSE------------------------------------- 1907

  Fly  3147 ESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNISTTTTTTTITNTTTTTNNPSSKAANSNN 3211
                                   ||.||...:||..
Human  1908 -----------------------DKEESMEIHATGK----------------------------- 1920

  Fly  3212 TTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKEELKL 3276
               |:.||:.||                     ...||:...|.|||||:||||||:||:::::
Human  1921 ---HSESNAELG---------------------QLYWPNTSTLTTRLRRLITAYQRSYKRQQMR- 1960

  Fly  3277 QQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDASGRSLQALMQSQGAS 3341
                                                                  .:|||::
Human  1961 ------------------------------------------------------QEALMKT---- 1967

  Fly  3342 TSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADISLMLSILNTTDVNQLANLDINKLAMY 3406

Human  1968 ----------------------------------------------------------------- 1967

  Fly  3407 LVSMNNKMERQGKMELAAKERE-----SQRLQLIPKKWNRREEYEFLRVLTGYGVDLHVSTPMAS 3466
                 ::..|:.:.|:.|.|.|     |::.|    ||.||||.:|.||::.:||   :..|:..
Human  1968 -----DRRRRRPREEVRALEAEREAIISEKRQ----KWTRREEADFYRVVSTFGV---IFDPVKQ 2020

  Fly  3467 SNGSSLSPDWTKFKQMAHLERKSDETLTDYYKVFVAMCKR--QAGLKLSESERGLEGIIEEIEKE 3529
            ..      ||.:|:..|.|::||||:|..|:..|||||:|  :..:|..:....|..|||.|.:|
Human  2021 QF------DWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEE 2079

  Fly  3530 HAKLILDRLEVLAKLRE-VARNPMLEERLKLCTKNADTPDWWEPGRHDKELITAVLKHGLYRSET 3593
            .|...|.|:|:|.|:|| |..:|.|.||||||..:.|.|:|||.||||::|:....|||:.|::.
Human  2080 RASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDY 2144

  Fly  3594 FIFNDPNFSFGESEKRFIRELEAQIQRTIKLEAFNAEKAEKLAAAEKDAATEKAAATEKAAAEKA 3658
            .|.|||..||.::.|.|.:...|.          |......||..
Human  2145 HILNDPELSFLDAHKNFAQNRGAG----------NTSSLNPLAVG-------------------- 2179

  Fly  3659 ASVKNEVIDLDDELMTNESVIKKESPVTPIKEEIKSEESPEKHDTADNLEDKNSDAEESTKIKGK 3723
                                ..:..||.                ::.:::|
Human  2180 --------------------FVQTPPVI----------------SSAHIQD-------------- 2194

  Fly  3724 EDFNPETTEKEALDESTNLNKDKSSTETLVPEIEDSKPSEDKMEVEELPVAENGEKEGSPEKCSD 3788
                     :..|::                       :|.|:|..|.|.|:        |||
Human  2195 ---------ERVLEQ-----------------------AEGKVEEPENPAAK--------EKC-- 2217

  Fly  3789 AEDKKFSEEKPSSPAVPDGKVSEMEADEAAPNTEENCSGDSESPEKECEDKVVEKVEEEKGENSY 3853
                             :||..|.|.|.:...:::.|..::.|.:.|.  |.|| |..:.|..|.
Human  2218 -----------------EGKEEEEETDGSGKESKQECEAEASSVKNEL--KGVE-VGADTGSKSI 2262

  Fly  3854 EKAEEQKEETEKLEKSSIESEPSEKSETVLEPEV-AVPK-KSTGDQDILDLVAGPSDPDDDEVMK 3916
            .:...:::|.|||       |..:|||...:||. ||.: |:..::....:.....:..|...|:
Human  2263 SEKGSEEDEEEKL-------EDDDKSEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYME 2320

  Fly  3917 EKEKAVEEECKKQAAELKARFPDLEVIQPATVKQQKLEKPKLEMCMIRWFKDFALERRIAHIVAC 3981
            :.:.:|.:...::.                             .....|.||..:..|:.:|...
Human  2321 DGDPSVAQLLHERT-----------------------------FAFSFWPKDRVMINRLDNICEA 2356

  Fly  3982 VESGNWPVDSK--YSAFATCKGATDLSIALHESIPHLSSLERRSTTPDVITITTDQGVTKHLQTS 4044
            |..|.|||:.:  :.......|.|..::.        |.|::||                ..:.|
Human  2357 VLKGKWPVNRRQMFDFQGLIPGYTPTTVD--------SPLQKRS----------------FAELS 2397

  Fly  4045 HMQQVASSASAASTSSGVPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLP 4109
            .:.|.:.|.|...|:|  ||:  ||..:.|
Human  2398 MVGQASISGSEDITTS--PQL--SKEDALN----------------------------------- 2423

  Fly  4110 GMSLSAATGSSAGGVSGLSVPSAGSGVGKKRKRHIAIDVETERA-------KLHALLNSSTMAPK 4167
                             ||||.      ::|:|...|::|.|||       ::.|.|..|.:..:
Human  2424 -----------------LSVPR------QRRRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSE 2465

  Fly  4168 DWESEIANMEALSGSSGRGRGGNSSASSGMQPPPAHQHASLSRQSSGQFSKPAVPAMKTPPPSMG 4232
            :.:.::.::...|      |...||.|:         .:|||       ||..:|.:.||
Human  2466 NGQEKVVDLSKAS------REATSSTSN---------FSSLS-------SKFILPNVSTP----- 2503

  Fly  4233 APMDLSSSLPKMNMTEMLKSASSSGAIDLSEVQDFSMPSKKSSVHAALSSAFPSM----GNKSKL 4293
                 .|...|..| |:|::.             .|....:..::.:|....|.|    |.:..:
Human  2504 -----VSDAFKTQM-ELLQAG-------------LSRTPTRHLLNGSLVDGEPPMKRRRGRRKNV 2549

  Fly  4294 D--DTLNKLMKKNNCTIEEPVIGKEKKRKKLDEIVLGLSAAKEQKTFPDPSLPSSKKPQIPPSVS 4356
            :  |.|....|:.:.:.|:..:.|              :..::.:|.|..::||  ..|:.|...
Human  2550 EGLDLLFMSHKRTSLSAEDAEVTK--------------AFEEDIETPPTRNIPS--PGQLDPDTR 2598

  Fly  4357 VTPANLQSSSNQQSNQKPFTITVTTVPGKSKSGSSNSGSGTGGSSSASGGGAGGSGLSALQNMAM 4421
            :...||:..:.......|          |:|
Human  2599 IPVINLEDGTRLVGEDAP----------KNK---------------------------------- 2619

  Fly  4422 GGLSSKDSLNALLAQTMATDPQTFLKQQQKMMQFLPPAQRKAYENMLAEMEQAMKISSKFSTNSP 4486
                                                            ::.:.:|:...::.:.|
Human  2620 ------------------------------------------------DLVEWLKLHPTYTVDMP 2636

  Fly  4487 HDVKVNKWLSDMTSPLGDQLSIDYVGGGGASGSGSGNSRRSNRQQGNSQQSSSAAQLQKQQQQQQ 4551
            ..|..|          .|.|...:
Human  2637 SYVPKN----------ADVLFSSF----------------------------------------- 2650

  Fly  4552 QQQQQQQQHSMPGP-----QNLTGEEPVPVINKQTGKRLGGNKAPQLKRLMQWLTENPNYEVDPK 4611
             |:.:|::|....|     ..|||||.|||:||:.||::||..||.:|.|.:||.|||.:.|.|.
Human  2651 -QKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPD 2714

  Fly  4612 WLEQMQNPMSTPSPR-----PASMESGYGSSAVKSHGGRPLSNLSSTSSSSHTQQQSSAAQSQAG 4671
            |.:.::.....|...     ...:..|.|:|   ..|.||.|.::          :::||.:...
Human  2715 WTDIVKQSGFVPESMFDRLLTGPVVRGEGAS---RRGRRPKSEIA----------RAAAAAAAVA 2766

  Fly  4672 GNSGSSKKNSRQQTAASAALDQAALQFGSLAGLNPSLLANL----PGLGAF-----DPKNPLAAF 4727
            ..||.   |.....:..|.:|..:||  :|..|....||.|    |||...     |.|||.|..
Human  2767 STSGI---NPLLVNSLFAGMDLTSLQ--NLQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVL 2826

  Fly  4728 DPKNPLLSMSFGGMPGMGNIPGLGNLNNMNLFASLAGMGGLGNLAGMDTQSLAALMAAAGPTLGG 4792
                ||:      :|||..:|        |:|    |:|||.|         ..|.||.|.|
Human  2827 ----PLM------LPGMAGLP--------NVF----GLGGLLN---------NPLSAATGNT--- 2857

  Fly  4793 LTGASGGAGSGKSQAQSQSSATSSSSSASKKKQQQQQQQAQNEAAQLAAAISASTGGSGASGGKN 4857
                        :.|.||.....|:|...:|..:.:.:...:|.:  ..|:||:...:|:.|...
Human  2858 ------------TTASSQGEPEDSTSKGEEKGNENEDENKDSEKS--TDAVSAADSANGSVGAAT 2908

  Fly  4858 AAASASQLAAGF-PFLFPN--PSLLYP----PMGLGGLN----PYSLG-SSGLGSAYDQLAQQYN 4910
            |.|........| |||...  |.|.||    |.|||||.    |...| .:.:||:.::.|.:..
Human  2909 APAGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAADKAE 2973

  Fly  4911 ---LLNGATSSASNTSSTQSKSHQS 4932
               ..:|.|...|:...:..|:.:|
Human  2974 GGPFKDGETLEGSDAEESLDKTAES 2998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	14/231 (6%)
		HepA	1676..2527	CDD:223627	448/852 (53%)
		SDA1	<1693..>1854	CDD:283052	5/160 (3%)
		CHROMO	<1879..1919	CDD:237991	22/39 (56%)
		Chromo	1941..1996	CDD:278797	30/54 (56%)
		DEXDc	2048..2197	CDD:238005	99/148 (67%)
		Helicase_C	2350..2464	CDD:278689	100/113 (88%)
		RR_TM4-6	3728..>3877	CDD:283990	29/148 (20%)
		BRK	4569..4613	CDD:197800	24/43 (56%)
CHD7	XP_011515855.1	Med15	202..>576	CDD:255446	112/509 (22%)
		Forkhead_N	306..423	CDD:254796	39/204 (19%)
		CHROMO	801..862	CDD:237991	32/272 (12%)
		Chromo	883..935	CDD:278797	30/55 (55%)
		SNF2_N	971..1258	CDD:278600	206/286 (72%)
		DEXDc	987..1136	CDD:238005	99/148 (67%)
		Helicase_C	1290..1404	CDD:278689	100/113 (88%)
		BRK	2594..2634	CDD:284864	7/131 (5%)
		BRK	2672..2716	CDD:197800	24/43 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	556	1.000	Domainoid score	I240
eggNOG	1	0.900	-	-		E2759_KOG0384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1539	1.000	Inparanoid score	I94
Isobase	1	0.950	-	0	Normalized mean entropy	S1758
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001075
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100621
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3575
SonicParanoid	1	1.000	-	-		X648
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.800