Protein Alignment kis and ttf2

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_005168676.1
• Gene: ttf2 / 555382
• ZFINID: ZDB-GENE-110411-73
• Length: 1145
• Species: Danio rerio
• Alignment Length: 1208
• Identity: 258/1208 - (21%)
• Similarity: 435/1208 - (36%)
• Gaps: 365/1208 - (30%)

  Fly  1511 PDSEMD--SNKRRSS----RNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASNSNAGS 1569
            ||.:.|  .|.:.||    ||..:.|...|..|:...|.::       :||:   ...::.|..:
Zfish   102 PDRQTDLLENLQSSSLTLVRNPFKVKIKQDKALKLRSDPDA-------EKDR---GEVNDENKHA 156

  Fly  1570 DVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNY 1634
            :|:..:.:........:..|..|              ...:..::.||:.|.|:.:....:.|
Zfish   157 NVQDNDKKRDERTGTTEREGNNK--------------KGPAVHSDTERRDSADSESWRNKTLP-- 205

  Fly  1635 VYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEG 1699
                ||            |::.||....:|||..|       |.....|::....|.|   |.:.
Zfish   206 ----TG------------MKIKKRVSDDEKPKSAA-------EDETCPESSNPVKEND---KGQT 244

  Fly  1700 ESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSE 1764
            ||:.:|.|.:|.....:.....|..:|.|...||:                  |:|:|....:|.
Zfish   245 ESENNLKDQQEQSPRKTGGSAQSPSKSSPGLDKKT------------------SNKQSTSNSKSG 291

  Fly  1765 TVKTEENSKAIEEDKSSTVLTADHAKEPETV-LEKMEVDEKANDDQSAV---------------- 1812
            :.||:..|.:....::.||     :::|..: ::|:|.::..|.|||.:
Zfish   292 SDKTQSQSPSCSTSQNGTV-----SEKPTALDVQKIEPNQSKNKDQSGIACFGEWSDEDDDVLVI 351

  Fly  1813 ------------------------------SKAEGSDEK--------STDDSNPEEATTEKNKES 1839
                                          ||.:|..|.        .|.....:...:..|..:
Zfish   352 SVQPPSQQSAPTPAVPVQKTITSYPGFQIASKVQGQSEDPRALHSQLKTQLKQKKATLSVVNVSA 416

  Fly  1840 LEIEGE--KERVKEGEESVK-------KENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCE 1895
            |..:||  |.:||:.||:::       .|:.:|..|:.|:|....|.:         .||   |.
Zfish   417 LPDKGERLKRQVKDLEEALESLSLTAVSESQDKDRAEAEHKTAHSFSN---------PFS---CP 469

  Fly  1896 WRT------EEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDE 1954
            ..|      ...:||.....:..: ...|..||...:      .|.:|.|
Zfish   470 GGTILLPTAPAAMLKESSSASLGL-NLSQGYSQMFGV------NPQSQAF--------------- 512

  Fly  1955 TSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEK 2019
            ..|..|::.|     |...:.|.|..:.: :|.:|.....|           ...|.....|:|
Zfish   513 YGGRMTENRL-----LAVRNATTEAIDHL-HDSLESCPTEN-----------TEAHDPKGLKVE- 559

  Fly  2020 TPVYKGGNSLRPYQLEGLNWLKFSWYNTHN-C--ILADEMGLGKTIQSLTFVHS----------- 2070
                     |.|:|...|.||  .|..|.. |  ||||:||||||:..:..:.|
Zfish   560 ---------LLPHQKRALTWL--LWRETQKPCGGILADDMGLGKTLTMIALILSQKKKDEKLEEW 613

  Fly  2071 VYEYG-----IRGPFLVIAPLSTIPNWQREFE---GWTDMNVVVYHGSVTSKQMIQDYEYYYKTE 2127
            :.::|     .:|. |:|.|.|.:.:|::|.:   ..:.:.|.:|||.             .:..
Zfish   614 ISKHGSSIVASQGT-LIICPASLVHHWKKEIDKRVKSSRLTVYLYHGP-------------NRQR 664

  Fly  2128 SGKVLKEPIKFNVLITTFEM---------------------IVTDYMDLKAFNWRLCVIDEAHRL 2171
            |..||.|   .:|:|||:.:                     :.:|...|....|...::||||.:
Zfish   665 SASVLAE---HDVVITTYSLVSKEIPVQKEDAEKPSKDSDHVASDLPPLLRVAWARVILDEAHSI 726

  Fly  2172 KNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF--GSLRTEE 2234
            ||...:....:.:|....|..::|||:|||:.:::|||.||..|.|...:.:.::.  ||.|..|
Zfish   727 KNPKVQTSMAVCKLRARSRWAVTGTPIQNNLLDMYSLLKFLRCSPFDEYKLWKAQVDNGSKRGGE 791

  Fly  2235 EVNKLQALLKPMMLRRLKDDVEK------SLAPKEETIIEVELTNIQKKYYRGILEQNFSFL--- 2290
            .:|   .|.:.::|||.||.::.      ||..:...|..::|:..::..|..:..|:.|.|
Zfish   792 RLN---ILTRALLLRRTKDQLDATGKPLVSLPDRTCEIHRLKLSEDEQAVYDVVFAQSRSTLQNY 853

  Fly  2291 ---------KKGTTS--------------------------ANIPNLMNTMMELRKCCIHPYLLN 2320
                     |||.||                          ::..::::.::.||:||.|..||.
Zfish   854 LKRHEDGNTKKGDTSNPFEKVAREFGMSQQDSQSSSQQPQASSTIHILSLLLRLRQCCCHLSLLK 918

  Fly  2321 ---------------GAEEQI------------QYDFKSQHGEDPESYYKNLILSAGKMVLIDKL 2358
                           ..|||:            ..|..|.:|   ..:...|.....:...|..:
Zfish   919 KTLDQSELQGDGVALSLEEQLCALSLSEPSDSENKDTVSLNG---SHFSSELFQDTRESTKISSI 980

  Fly  2359 LPKLK---ANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRF 2420
            |.:||   ....:.:|.||....|.|:..:|......|..|||.:....|.:.::.::.......
Zfish   981 LTELKEIRKKDQKSVIVSQWTSMLKIVAVHLEKMGLKFAVIDGTVNPKRRMDLVEEFNTNPKGPQ 1045

  Fly  2421 VFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMF 2485
            |.|:...|||:||||...:.:.:.|..|||..:.||..|.:|:||.|.|.|:|.:|..|.|.::.
Zfish  1046 VMLVSLCAGGVGINLIGGNHLFLIDMHWNPALEDQACDRIYRVGQSKDVTIHRFVCDGTVEDKIS 1110

  Fly  2486 DKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDL 2523
            .....|..|.:.||         .|.....:|..:.||
Zfish  1111 SLQEKKKELAQKVL---------SGTGSSFTKLSLADL 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	91/487 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	14/79 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	10/57 (18%)
		PLN03142	2029..>2606	CDD:215601	151/614 (25%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
ttf2	XP_005168676.1	zf-GRF	4..42	CDD:480736
		PRK08581	138..>318	CDD:236304	46/254 (18%)
		DUF612	<206..457	CDD:282585	58/295 (20%)
		HepA	<550..1125	CDD:440319	150/618 (24%)
		DEXHc_TTF2	560..804	CDD:350830	71/265 (27%)