DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kis and hells

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_001032178.1 Gene:hells / 553328 ZFINID:ZDB-GENE-030131-9923 Length:853 Species:Danio rerio


Alignment Length:993 Identity:298/993 - (30%)
Similarity:458/993 - (46%) Gaps:265/993 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1670 PEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAME--VDSKEESEPDDSK 1732
            |:|.:.||           |||              |..|||.:|.|..|  |.:||..|.:.:.
Zfish    17 PKPNESEE-----------PEG--------------TTIEETTMEKSKHEEMVITKEMEEEEKNL 56

  Fly  1733 KSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDK--SSTVLTADHAKEPETV 1795
            :.:.:.|:::.||       ..::|:..: |:.::.:.....:|:..  |..:||....::.|..
Zfish    57 EEEGEKKEREMME-------EARQSRGND-SQEMRFKRLQHLLEKSNIYSKFLLTKMEQQQQEEK 113

  Fly  1796 LEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKEN 1860
            |:|..:::||     ||.|.:|||:|:.                     :.||.|.|.|..|   
Zfish   114 LKKERLEKKA-----AVLKQKGSDKKTV---------------------KVERKKRGREDYK--- 149

  Fly  1861 DEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLN 1925
                           ..||                 .|:||::       :|.::.:.::..|.:
Zfish   150 ---------------IADV-----------------MTKEEIM-------SKAKKPKMEEEAQAS 175

  Fly  1926 IFENIED-EPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIE 1989
            :....|| |..:      |...|:.....||..|.:|..|             :.|..|:.    
Zfish   176 VKLEAEDIEKLS------DTNSDIKGRLSETLRENSKQML-------------DPERTVNG---- 217

  Fly  1990 QYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILAD 2054
                 ..:|.:         .|:|:.          |..:|.||:||:.||:..|.|..|.||||
Zfish   218 -----QPVPAQ---------QPQLFT----------GGVMRWYQVEGIEWLRMLWENGINGILAD 258

  Fly  2055 EMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQ 2118
            |||||||||.:..:..:.|..:.|||||:|||||:|||..||:.:| :::|::|||  ..|:.: 
Zfish   259 EMGLGKTIQCIAHIAMMVEKKVLGPFLVVAPLSTLPNWISEFKRFTPEVSVLLYHG--PQKERL- 320

  Fly  2119 DYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLR 2183
            |.....:...|.:...|    |::|:||:.:.|...|:.|:|...::||.||:||.||:|::.|:
Zfish   321 DLVKKIRQHQGSLRMCP----VVVTSFEIAMRDRKFLQRFHWNYLIVDEGHRIKNLNCRLVQELK 381

  Fly  2184 QLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEF-------------GSLRTEEE 2235
            .|..::::||:|||||||:|||:||||||.|..|...:.|.|.|             .:.|.:..
Zfish   382 MLPTDNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDISTITSDAENIVANEREQNI 446

  Fly  2236 VNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFS------------ 2288
            ::.|..:|.|.:|||||.||...:.||:|.::...|||.|:.:|..|:.:..:            
Zfish   447 LHMLHLILTPFLLRRLKSDVTLEVPPKKEIVVYAPLTNKQEAFYMAIVNKTIAKLLGQEKDESAP 511

  Fly  2289 --------------------------------FLKK----------GTTSANI--P-------NL 2302
                                            :|:|          .|...|:  |       .|
Zfish   512 APLTPSGRPKRRSRKVVNYTEPNTDSMKDLEKYLEKVQQELDSQASSTPVVNVFMPVDAQVNLKL 576

  Fly  2303 MNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGH 2367
            .|.:|.|::||.|.||:....:....|||..         :.|:.::||.:::|::||:||..||
Zfish   577 QNILMLLKRCCNHAYLIEYPLDPTTGDFKID---------EQLVEASGKFLILDRMLPELKKRGH 632

  Fly  2368 RVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLG 2432
            :|||||||...||||.||...|.|.:.|:||.:....|.|.:.::|. ..:.|:|||.|:|||||
Zfish   633 KVLIFSQMTSILDILMDYCYLRGYEYSRLDGSMSYADRDENMKKFSS-DPEVFLFLLSTRAGGLG 696

  Fly  2433 INLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKA 2497
            ||||:||||||:|||||||.|||||.|||||||.|.|.::||:..||.:.::.::||.|..|:|.
Zfish   697 INLTSADTVIIFDSDWNPQADLQAQDRCHRIGQTKPVVVHRLITANTIDEKILERASAKRKLEKM 761

  Fly  2498 VLQSMNTQGSKDGNNKQ----LSKKEIEDLLK--------KGAYGAVMDDDNAGDKFCEEDIDSI 2550
            |:.....:||| ...||    |...|:.:|||        ||..|.|:.|.:........|:...
Zfish   762 VIHKNKFKGSK-AELKQSKSCLDVDELVELLKSRDYDGAVKGTKGKVISDKDLQILLDRSDLMDQ 825

  Fly  2551 LKRRTQVITMESEKGSTF 2568
            .|:|     ::.||...|
Zfish   826 AKKR-----VKQEKDGVF 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171
PTZ00121 <1419..1923 CDD:173412 51/256 (20%)
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315 9/66 (14%)
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 9/57 (16%)
PLN03142 2029..>2606 CDD:215601 230/629 (37%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
hellsNP_001032178.1 nuclear localization signal 140..145 2/4 (50%)
PLN03142 224..>813 CDD:215601 227/616 (37%)
DEXHc_HELLS_SMARCA6 230..463 CDD:350767 98/239 (41%)
conserved domain I 241..265 14/23 (61%)
conserved domain Ia 285..294 7/8 (88%)
conserved domain II 353..371 7/17 (41%)
leucine zipper motif 389..410 16/20 (80%)
conserved domain III 390..397 5/6 (83%)
conserved domain IV 456..466 6/9 (67%)
Shugoshin_C 518..>534 CDD:462207 0/15 (0%)
conserved domain IVa 580..592 5/11 (45%)
conserved domain IVb 631..642 9/10 (90%)
conserved domain V 688..701 10/12 (83%)
conserved domain VI 719..729 8/9 (89%)
Blue background indicates that the domain is not in the aligned region.

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