DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and ERCC6L

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_060139.2 Gene:ERCC6L / 54821 HGNCID:20794 Length:1250 Species:Homo sapiens


Alignment Length:1369 Identity:312/1369 - (22%)
Similarity:521/1369 - (38%) Gaps:386/1369 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1956 SGETTKHYLVKWKSLPYEDCTWELEE---------DV-DNDKIEQYLRFNKIPQRSEWKSKKRPH 2010
            |.|...|||...|.........:|||         |: .|:|:  ..|..||.:..|..:::...
Human    14 SPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKV--LSRIQKIQEALEELAEQGDD 76

  Fly  2011 PELWKKLEKTPVYKGG--------NSLRPYQLEGLNWLKFSWY--NTHNCILADEMGLGKTIQSL 2065
                   |.|.|...|        |.|..:|.||:.:| :|.|  .....||||:||||||:|.:
Human    77 -------EFTDVCNSGLLLYRELHNQLFEHQKEGIAFL-YSLYRDGRKGGILADDMGLGKTVQII 133

  Fly  2066 TFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESG 2129
            .|:..:::..:....|:|.|.:.|..|.:||..|| .|.|..:||.             .|.|..
Human   134 AFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGP-------------SKDERT 185

  Fly  2130 KVLKEPIKFN-VLITTFEMIVTDYMDLKAFN-----WRLCVIDEAHRLKNRNCKLLEGLRQLNLE 2188
            :.|....:.| |:|||::|::.::..|.:|.     |...::||||::|..:.|.....|.:...
Human   186 RNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAICARAIPAS 250

  Fly  2189 HRVLLSGTPLQNNISELFSLLNF-LEPSQFSSQEEFMSEFGS--LRTEEE-------------VN 2237
            :|:||:|||:|||:.||:||.:| .:.|...:.:.|..|:.:  .|..|:             ..
Human   251 NRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPGEKALGFKISE 315

  Fly  2238 KLQALLKPMMLRRLKDDVEK------------------------SLAPKEETIIEVELTNIQKKY 2278
            .|.|::||..|||.|:||:|                        ||:.|.:.||.:.|..:|::.
Human   316 NLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEI 380

  Fly  2279 YRGILEQNFSFLKKGTTSANIPNLMNTMME----------LRKCCIHPYLL-------------- 2319
            ||..:              ::.::...:||          |:|.|.||.||              
Human   381 YRKFV--------------SLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFS 431

  Fly  2320 ----NGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLD 2380
                |..|:....|...|..:|      .|:..:|||:.:..||.:|:..||:.|:|||..:.|:
Human   432 AQDGNEGEDSPDVDHIDQVTDD------TLMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILN 490

  Fly  2381 ILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYD 2445
            |:|..|..|.:...||||.:...|.:|......:...|..||||.|:.||:|:.||||..|:|:|
Human   491 IIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFD 555

  Fly  2446 SDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDG 2510
            ..|||..|.||..|.:||||::.|.:|||:...|.|.:::.:...|   |..:.|   |.|.|..
Human   556 PSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFK---DSLIRQ---TTGEKKN 614

  Fly  2511 NNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDI-DSILKRRTQVITMESEKGSTFSKASFA 2574
            ..:..||:|:.:|                  |..||: :|:.:.:.|               |..
Human   615 PFRYFSKQELREL------------------FTIEDLQNSVTQLQLQ---------------SLH 646

  Fly  2575 ASGNRSDITIDDPDFWTKWAKKVDI----DPD---ACERDETEDLVLSEP----RRRTQIKRY-- 2626
            |:..:|||.:|:   ...:.:.:.|    |.|   .|:....|:|.:.|.    ::|.|..::  
Human   647 AAQRKSDIKLDE---HIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLV 708

  Fly  2627 -----GHEDVME--------------------------LNSEE-------SSNENSDEEGGIGLR 2653
                 ..|.:||                          ||..:       |::...:|:....:.
Human   709 EFESQNKEFLMEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMA 773

  Fly  2654 S------RRRKEKRDRA---------REKKGNDEYIPRERDALAAL-----GLEEIQYGNWAKSE 2698
            |      .:..||:|.:         ::.||..     ..|::|.|     .:||:     ..:.
Human   774 SVVIDDLPKEGEKQDLSSIKVNVTTLQDGKGTG-----SADSIATLPKGFGSVEEL-----CTNS 828

  Fly  2699 CFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYC-------LQVYKGDEKIK-T 2755
            ...:||...:.......|.|:.|..:...::..:|....::....       |...|.||.:: .
Human   829 SLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHC 893

  Fly  2756 FIWDLITPTEDGE-------VQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPG-------S 2806
            ..|.:|:.|.:.:       :.:|:.|.|..|:.:...:......:|....|:|...       .
Human   894 NPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLE 958

  Fly  2807 ASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPN--HWSKKEKYDADAYLEGAYK 2869
            .|..|..|    ..|.:|:..:|:: .:..||..:....:|...  .|...||.|...  |...|
Human   959 DSADNRQN----FSSQSLEHVEKEN-SLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPE--EVVVK 1016

  Fly  2870 KHLGRHANKVL------------------LRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPP 2916
            ..:...|.:::                  ....:..:       ..|:|...:||.::  |.||.
Human  1017 AKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQF-------SSVKQFDASTPKND--ISPPG 1072

  Fly  2917 T--PDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNL--CFVTHVGAGAAGDDLAVTSLP 2977
            .  ..|:|||      .:||:         ...|.:.:..:|  ..:.||               
Human  1073 RFFSSQIPSS------VNKSM---------NSRRSLASRRSLINMVLDHV--------------- 1107

  Fly  2978 INEDDANSKHDDG--------------DEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPERPSSSG 3028
               :|...:.||.              :|...:.:..|::..|.:....:||.|.|...:||:..
Human  1108 ---EDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALA 1169

  Fly  3029 KSSSENAS---GGNDKTESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDAL----------SA 3080
            :.:|..|.   .|.....|..|....:.:.|  |.|..:|.:|......|:||          ||
Human  1170 QETSLGAPEPLSGEQLVGSPQDKAAEATNDY--ETLVKRGKELKECGKIQEALNCLVKALDIKSA 1232

  Fly  3081 TPEL 3084
            .||:
Human  1233 DPEV 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171
PTZ00121 <1419..1923 CDD:173412
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 13/48 (27%)
PLN03142 2029..>2606 CDD:215601 186/661 (28%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
ERCC6LNP_060139.2 TPR 1 21..54 7/32 (22%)
HepA <90..610 CDD:440319 166/559 (30%)
DEXHc_ERCC6L 96..328 CDD:350759 75/245 (31%)
DEAH box 228..231 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..768 4/32 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..946 1/19 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1061..1092 11/47 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1110..1199 16/88 (18%)
TPR 2 1200..1233 9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

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