DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and ATRX

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_000480.3 Gene:ATRX / 546 HGNCID:886 Length:2492 Species:Homo sapiens


Alignment Length:2403 Identity:471/2403 - (19%)
Similarity:837/2403 - (34%) Gaps:820/2403 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   624 VAASQQQQQQQHQQQSLNDQLQHSINDIVGGGNSSGATGGAQNQHQQQPQLAAMSSPLHQQNLPN 688
            :|..:....:.....::|.:.....:.::.....:.|..|.:....::..::...:.|.::.:.:
Human   407 LALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDS 471

  Fly   689 MH-HLIQPTME--TTQPTQQQQQTSQQQQQPQQPQATLTS-------------PH------HQQM 731
            .| |...||.|  |.:.|..:.:.|.::::||...|..:.             |.      ...|
Human   472 EHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAM 536

  Fly   732 QHQSPI-HQQQQSPHHQQHLPSYNQSQQQFDPFANILG-DNQPAASQQT-----------MSPAH 783
            :.||.: ||...|...:|.:.|.:..       .||.. ||:.....:|           ::|..
Human   537 EVQSSVDHQGDGSSGTEQEVESSSVK-------LNISSKDNRGGIKSKTTAKVTKELYVKLTPVS 594

  Fly   784 VS-SPVP-AQMQQ----------------------------QQHQTQQQPSQQVPQSQQQQVSQP 818
            :| ||:. |..|:                            .:|..:.:.|..:.:|..::  .|
Human   595 LSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRR--SP 657

  Fly   819 QQQTQQQQPSTPSHHLSS----ILNETANSNDSSTLAVAANDSNNSSSNSSTNSIVNNQPTSVHD 879
            :.:|...:..|.::.::|    ..|||.......::.|...|..|||.    ::|.|.:|..:..
Human   658 RVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD----SAIDNPKPNKLPK 718

  Fly   880 SNSQSSINSSSNNQQQLLMDNTNSHGGNSESAQNAGVDVGLFDNNSMSSNSAAVAAVASNAASAA 944
            |....:::.:|::.:.|.:....|...:|.|:..        |.|.:.:|...:..:.:.|....
Human   719 SKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDT--------DINEIHTNHKTLYDLKTQAGKDD 775

  Fly   945 AALLDSNSQSSNAEFEKNQSEGEGLGVVEGVIANETDLPQDENSVSKTQDITLSTELPTIQDDLQ 1009
            .......|.:|.::|:..    :|......:|:.:....|.|:|   ..|..|..|:.::     
Human   776 KGKRKRKSSTSGSDFDTK----KGKSAKSSIISKKKRQTQSESS---NYDSELEKEIKSM----- 828

  Fly  1010 EKPTAEMEQTQLGQSLGDLSKSLLEEPKTVE-ESGEDKSQSAPGVAPPADPIIPVTQPPQQQMPP 1073
                         ..:|....:....|.|.: :|.||:..|..|:                    
Human   829 -------------SKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM-------------------- 860

  Fly  1074 IGMPMHPIAPGYEAQAQGQGHMPPMMPPYGGAPGMYPPYPMLHQQEIAALQQQIQELYCMPPGHE 1138
                            ..|||........|.:..              |.::|.:|.:....| .
Human   861 ----------------DNQGHKNLKTSQEGSSDD--------------AERKQERETFSSAEG-T 894

  Fly  1139 LQHQDKLMRMQERLNLLTQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPLLNQQMVESPQVSSTTG 1203
            :.....:|.:::||                                 |...|....:..|...:|
Human   895 VDKDTTIMELRDRL---------------------------------PKKQQASASTDGVDKLSG 926

  Fly  1204 RGRGKSANKPRKPRAKKGEKAQVGQQQDLMDISGNVAMGAANAVSSIPTTQLPVSEDCVTQGAGD 1268
            :....::.:.||. |:..||::                       .:.|......:|        
Human   927 KEESFTSLEVRKV-AETKEKSK-----------------------HLKTKTCKKVQD-------- 959

  Fly  1269 TSVVGMLEYSEGMGDLSQDVHSANELDTSTDGSGKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDP 1333
                       |:.|:::..               .||.:...|.:|..|..:..|.:.|||.| 
Human   960 -----------GLSDIAEKF---------------LKKDQSDETSEDDKKQSKKGTEEKKKPSD- 997

  Fly  1334 NDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEV----EDNKPLVPKAGSADGEAETTSG 1394
                       .||:....:::.:...||.|:..|..|:    :..|.:  |.|:.|||.::...
Human   998 -----------FKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQI--KNGTTDGEKKSKKI 1049

  Fly  1395 GTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSR--RDRKR----- 1452
            .   |..|...|::        |:..||....||..     ||:.|..|....  |::||     
Human  1050 R---DKTSKKKDEL--------SDYAEKSTGKGDSC-----DSSEDKKSKNGAYGREKKRCKLLG 1098

  Fly  1453 STARSRRNANSE--EGGSARKNRGSLSAKALKK-----------RRNRGRIVPESDGEDDTLDRT 1504
            .::|.|::.:|.  |..|.:::..:.|.|.||:           :||...|...|...|      
Human  1099 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSD------ 1157

  Fly  1505 PPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANAS------ 1563
                  .:...:.||::..|.:.:||                  |..||:.|:.|...|      
Human  1158 ------AEESSEDNKKKKQRTSSKKK------------------AVIVKEKKRNSLRTSTKRKQA 1198

  Fly  1564 --NSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANA 1626
              .|::.||:|..:..|..||.:     :|:...|:.|:  |..||.|...     |.|.|.|  
Human  1199 DITSSSSSDIEDDDQNSIGEGSS-----DEQKIKPVTEN--LVLSSHTGFC-----QSSGDEA-- 1249

  Fly  1627 AMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELI------LDKPKEKAPEPKQDEEKSELDEAT 1685
              .||...|.::..|:|:....     |:.|:.|:      |...::.:.:.:.:|.|....:..
Human  1250 --LSKSVPVTVDDDDDDNDPEN-----RIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQN 1307

  Fly  1686 TDKPEGDEKFKTEGESKKDLTDSEET------------KLESSAMEVDSKEESEPDDSKK----- 1733
            .:.| |||:.|.:..|:.| :||||:            ||..|..|...:::::|.:.|:     
Human  1308 EENP-GDEEAKNQVNSESD-SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN 1370

  Fly  1734 ----SDEDNKDKDKME--VDDEVGKSDKESKPEEQS-ETVKTEENSKAIEEDKSSTVLTADHAKE 1791
                |.||::|.|..|  |.:||.:|:.|.:|..:| :..:.|||.::.::.|..          
Human  1371 RRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR---------- 1425

  Fly  1792 PETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESV 1856
                 .:::|.|               |..|.:.||.||...||.:|      |:|..:|.||..
Human  1426 -----RRIKVQE---------------DSSSENKSNSEEEEEEKEEE------EEEEEEEEEEEE 1464

  Fly  1857 KKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQS 1921
            .:.:|.|:......|...:..| ::...:.:|      ..:.|||..|   |:|.:     :::.
Human  1465 DENDDSKSPGKGRKKIRKILKD-DKLRTETQN------ALKEEEERRK---RIAER-----ERER 1514

  Fly  1922 QQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYE--------DCTWE 1978
            ::|.....|||....:.......|||....|.|...:..::.::|.|  |::        ||..|
Human  1515 EKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLK--PHQVDGVQFMWDCCCE 1577

  Fly  1979 LEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFS 2043
                                  |..|:||.|                |:                
Human  1578 ----------------------SVKKTKKSP----------------GS---------------- 1588

  Fly  2044 WYNTHNCILADEMGLGKTIQSLTFVHSV-----YEYGIRGPFLVIAPLSTIPNWQREFEGW---- 2099
                 .||||..||||||:|.::|:|:|     .::...   ||:.||:|..||..|||.|    
Human  1589 -----GCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTA---LVVCPLNTALNWMNEFEKWQEGL 1645

  Fly  2100 -TDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDL-------- 2155
             .|..:.|...:...:...:.|......|.|         .|:|..:||    |.:|        
Human  1646 KDDEKLEVSELATVKRPQERSYMLQRWQEDG---------GVMIIGYEM----YRNLAQGRNVKS 1697

  Fly  2156 ----KAFNWRL-------CVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLL 2209
                :.||..|       .|.||.|.|||....:.:.:..:....|::|:|||||||:.|...::
Human  1698 RKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMV 1762

  Fly  2210 NFLEPSQFSSQEEFMSEF----------GSLRTEEEVNKLQA-----LLKPMMLRRLKDDVEKSL 2259
            ||::.:...|.:||.:.|          .|...:..|.|.:|     :|...:.|:....:.|.|
Human  1763 NFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFL 1827

  Fly  2260 APKEETIIEVELTNIQKKYYRGILEQ-----NFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLL 2319
            .||.|.::.|.:|:||.|.|:..|:.     |.|...:|...|   .|......|.:...||:.|
Human  1828 PPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGA---KLFQDFQMLSRIWTHPWCL 1889

  Fly  2320 --------------------------------------------------------NGAEEQIQY 2328
                                                                    :|::..::.
Human  1890 QLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEV 1954

  Fly  2329 ------------------------------DFKSQHGEDPES----YYKNLILSA--------GK 2351
                                          :.|:....:|.|    :||:.:..|        ||
Human  1955 IKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGK 2019

  Fly  2352 MVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDY---------------LVY-------RKYPFE 2394
            |||:.::|...:..|.:||:|||.:..||::||:               |:|       |...:.
Human  2020 MVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYY 2084

  Fly  2395 RIDGRIRGNLRQEAIDRYSKPGSDR-FVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQA 2458
            |:||......|::..:.::...:.| .:|::.||||.|||||.||:.|||:|:.|||..|:|:..
Human  2085 RLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIF 2149

  Fly  2459 RCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDL 2523
            |.:|.||.|.|.:||.|.:.|.|.:::|:...|        ||::.:                  
Human  2150 RVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTK--------QSLSFR------------------ 2188

  Fly  2524 LKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGNRSDITIDDPD 2588
                    |:|.......|...::       |::.|.|.:                   .:|||:
Human  2189 --------VVDQQQVERHFTMNEL-------TELYTFEPD-------------------LLDDPN 2219

  Fly  2589 FWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKR------YGHEDVMELNSEESSNENSDEE 2647
            ...|..:...:.|        :|.:|:|   ..||.:      :.|:.:::...||   |.::||
Human  2220 SEKKKKRDTPMLP--------KDTILAE---LLQIHKEHIVGYHEHDSLLDHKEEE---ELTEEE 2270

  Fly  2648 GGIGLRSRRRKEKRDRAREKKG------------------NDE--YIPRERDALAALGLEEIQ 2690
                    |:....:...||||                  |.:  |||....||:|:..::::
Human  2271 --------RKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLE 2325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941 22/208 (11%)
PRK12678 1319..>1500 CDD:237171 47/204 (23%)
PTZ00121 <1419..1923 CDD:173412 126/561 (22%)
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315 14/66 (21%)
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 11/65 (17%)
PLN03142 2029..>2606 CDD:215601 167/746 (22%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
ATRXNP_000480.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..147
ADDz_ATRX 167..270 CDD:277252
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..516 13/70 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..576 12/47 (26%)
PxVxL motif 581..594 1/12 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..616 5/22 (23%)
PTZ00108 <642..857 CDD:240271 44/253 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..956 66/453 (15%)
PTZ00121 <791..1438 CDD:173412 170/926 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1479 144/644 (22%)
Interaction with DAXX 1189..1326 37/159 (23%)
HepA <1543..2191 CDD:440319 171/761 (22%)
DEXHc_ATRX 1560..1803 CDD:350826 76/319 (24%)
DEGH box 1719..1722 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1913..2000 4/86 (5%)
Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936 2010..2280 83/351 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2462..2492
Blue background indicates that the domain is not in the aligned region.

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