DRSC/TRiP Functional Genomics Resources

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Protein Alignment kis and SMARCAL1

DIOPT Version :10

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens


Alignment Length:1027 Identity:221/1027 - (21%)
Similarity:352/1027 - (34%) Gaps:307/1027 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1667 EKAPE-PKQDEEKSELDEA---------------TTDKPEGDEKFKTEGESKKDLTDSEETKLES 1715
            :..|| |||.....||.:.               .|.||....|            .|:||...|
Human   128 QSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPK------------SSQETPAHS 180

  Fly  1716 SAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENS--KAIEED 1778
            |.        ..|.|:|...:..|.....:....:..|.:...|..:....:...:|  |.:...
Human   181 SG--------QPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQ 237

  Fly  1779 KSSTVLTADHAK---------------------EPETVLEKMEVDEKANDDQSAVSKAEGSDEKS 1822
            |...|...|..:                     :|:|......:     :|.||:.||  :....
Human   238 KGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSM-----NDYSALMKA--AQSLP 295

  Fly  1823 TDDSNP-EEATTEKNKESLEIEGEKERVKEGEESVKKENDEK----------TEADMENKPEPVF 1876
            |.:..| |.|.......|...||:     .|..|....:..|          .|||:....:.:.
Human   296 TVNLQPLEWAYGSSESPSTSSEGQ-----AGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIA 355

  Fly  1877 I----DVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQ 1937
            :    |...|.||.|.:|:          ||:...::.||:|...|           ::.:|...
Human   356 LFKQMDSRRYDVKTRKWSF----------LLEEHSKLIAKVRCLPQ-----------VQLDPLPT 399

  Fly  1938 DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSE 2002
            ..|     |..:....:||...|       ..:|..|.:     :||                  
Human   400 TLT-----LAFASQLKKTSLSLT-------PDVPEADLS-----EVD------------------ 429

  Fly  2003 WKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTF 2067
                    |:|            .::|.|:|..|:|   |:.......:|||:||||||||::..
Human   430 --------PKL------------VSNLMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICI 471

  Fly  2068 VHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTD------MNVVVYHGSVTSKQM-------IQD 2119
            ...   |....|.||:.|.|....|::.|..|..      :|||     ||.|..       |..
Human   472 AAF---YRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVV-----VTGKDRLTAGLINIVS 528

  Fly  2120 YEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKN-RNCKLLEGLR 2183
            ::...|.|  |.||.|.|                        :.:|||:|.||| |..:....:.
Human   529 FDLLSKLE--KQLKTPFK------------------------VVIIDESHFLKNSRTARCRAAMP 567

  Fly  2184 QLNLEHRV-LLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRT---------EEEVNK 2238
            .|.:..|| ||||||..:..:||::.:..::|:.|.....|...:...:.         ...:.:
Human   568 VLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGE 632

  Fly  2239 LQALL-KPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNL 2302
            |:.|| :.:||||||.||...|..|:..|:.:....|..:                |.:|     
Human   633 LKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRINAR----------------TRAA----- 676

  Fly  2303 MNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGH 2367
                           |...|:|....|...|..:|....:.|....|....:|:.:|..|::...
Human   677 ---------------LDAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGRE 726

  Fly  2368 RVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRF-VFLLCTKAGGL 2431
            :.|:|:.....||.:...|..:.....||||......|::...::..  |:|. |.:|...|..:
Human   727 KFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHAVAVLSITAANM 789

  Fly  2432 GINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFD------KASM 2490
            |:..::||.|:..:..|||...:||:.|.|||||...|.|:.|:.:.|.:..::.      |...
Human   790 GLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLA 854

  Fly  2491 KLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKG--AYGAVMDDDNAGDKFCEEDIDSILKR 2553
            :.||.:.....|..  |.|...|...:::|.||.:|.  ..|:.|:...|.:.|           
Human   855 EAGLSETNFSEMTE--STDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAESF----------- 906

  Fly  2554 RTQVITMESEKGSTFSKASFAASGNRSDITIDDP------------DFWTKW 2593
                     :.||. |..|.::|.|..| |:|:.            :|:..|
Human   907 ---------DPGSA-SGTSGSSSQNMGD-TLDESSLTASPQKKRRFEFFDNW 947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171
PTZ00121 <1419..1923 CDD:173412 59/309 (19%)
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315 17/80 (21%)
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 9/57 (16%)
PLN03142 2029..>2606 CDD:215601 150/611 (25%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238 24/129 (19%)
HARP 248..302 CDD:462166 8/60 (13%)
HARP 343..397 CDD:462166 15/74 (20%)
HepA <423..856 CDD:440319 130/550 (24%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 67/245 (27%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 8/16 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934 10/51 (20%)
Blue background indicates that the domain is not in the aligned region.

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