Protein Alignment kis and smarca4

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001362194.1
• Gene: smarca4 / 496545
• XenbaseID: XB-GENE-483983
• Length: 1599
• Species: Xenopus tropicalis
• Alignment Length: 1939
• Identity: 459/1939 - (23%)
• Similarity: 718/1939 - (37%)
• Gaps: 599/1939 - (30%)

  Fly  1072 PPIGMPMHPI-------------------APGYEAQAQGQGHMPPMMPPYGGAPGMYPPYPMLHQ 1117
            ||:|....|:                   :||......|....|| :||.|  |..|||..| ||
 Frog     6 PPMGGTPRPVPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPP-IPPQG--PAGYPPENM-HQ 66

  Fly  1118 QEIAALQQQIQELYCMPPGHELQHQDKLMRMQERLNLLTQHEVNDQCAGGPQCLLFQNVPPMYGP 1182
                 :.:.:..::           ||.:....|.|.:....:......|            .||
 Frog    67 -----MHKPMDSIH-----------DKAIPEDPRYNQMKGMSMRPAAHSG------------MGP 103

  Fly  1183 P-----------GNPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVGQQQDLMDIS 1236
            |           .:||.|.:.|.||..|:    |.......|..|.|...|.:...||
 Frog   104 PPSPMDQHSQGYPSPLGNSEHVPSPVPSN----GPPSGPPMPSGPSAVNMENSDPQQQ------- 157

  Fly  1237 GNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTSTDGS 1301
                      .|..||   |.:::.:.|.........||...:.:.|         .|..:..|
 Frog   158 ----------TSRSPT---PFNQNQLHQLRAQIMAYKMLARGQALPD---------HLQMAVQG- 199

  Fly  1302 GKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQT 1366
               |:|......:.|..||                     |||....||.:.
 Frog   200 ---KRPMPGMQQQMPTLPP---------------------PAASGTGAGPAP------------- 227

  Fly  1367 GEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETV 1431
                     .|:.|......|.|..|....|..|..|.....|....|:...|....
 Frog   228 ---------GPVPPNYNRPHGMAGPTMPPPGPSGAPPGMPGHPAGAPPKPWPEGPMA-------- 275

  Fly  1432 DSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVP---E 1493
                 :|..||:.|.:....:.|.|.                 |.:..|:....:  .::|   :
 Frog   276 -----NAAAPATAPQKLIPPQPTGRP-----------------SPAPPAVPPAAS--PVMPPQTQ 316

  Fly  1494 SDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKP 1558
            |.|:        |..|||                        :::|....|.:   :|::|.:
 Frog   317 SPGQ--------PAQPPP------------------------IVQFHPKPNRI---TPIQKPR-- 344

  Fly  1559 SANASNSNAGSDVEKT--EPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQIST 1621
                     |.|..:.  |.:...:...|..: :|..|||    ..|.....|.|..|.:
 Frog   345 ---------GLDPVEVLQEREYRLQARIAHRI-QELENLP----GSLPGDLRTKATIELK----- 390

  Fly  1622 DAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEP-------KQDEEKS 1679
                                    .::|:...|..::|:::...::.|.|.       |:.:.:|
 Frog   391 ------------------------ALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQS 431

  Fly  1680 ELDEATTDKPEGDEKFKTEGESK--------------KDLTDSEET------KLESSAMEVDSKE 1724
            ..:...|:|.|..:|.:.|.:.:              ||..:...:      ||..:.....:..
 Frog   432 LREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEFHRSVTGKIQKLTKAVATYHANT 496

  Fly  1725 ESEPDDSKKSDEDNKDKDKME---VDDEVG-------KSDKE-----SKPEEQ----SETVKTEE 1770
            |.|    :|.:.:..:|::|.   .:||.|       |.||.     .:.:|.    :|.|:..:
 Frog   497 ERE----QKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHK 557

  Fly  1771 NSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEK 1835
            ..:|::|.|..               :|.:|.|.....|||:.          .|..|.:.|::.
 Frog   558 AVQALKEKKRR---------------KKKKVQEITEGQQSALG----------PDGEPLDETSQM 597

  Fly  1836 NKESLE-IEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTE 1899
            :...:: |..|..::..|.::.|.   .:.||.:|..|        .|.|..|:.:. ..|...|
 Frog   598 SDLPIKVIHVESGKILTGADAPKA---GQLEAWLEMNP--------GYEVAPRSDTE-ESESEDE 650

  Fly  1900 EELLKGDRRVAAKIRRFQQKQSQQLNI--------FENIEDEPFNQDFTEVD--RVLD------- 1947
            ||               ::.:.||.::        .:.|.| |.:.|.:||.  .::|
 Frog   651 EE---------------EEDEQQQPSVTSLLAVDETKKIAD-PDSDDVSEVHAREIIDNARQDVD 699

  Fly  1948 --MSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPH 2010
              ..:...|||| ...:|.|          ...:.|.||.   :..|..|.|
 Frog   700 DEYGISHAETSG-LQSYYAV----------AHAVSEKVDK---QSTLLVNGI------------- 737

  Fly  2011 PELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEY- 2074
                              |:.||::||.||...:.|..|.|||||||||||||::..:..:.|:
 Frog   738 ------------------LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHK 784

  Fly  2075 GIRGPFLVIAPLSTIPNWQREFEGWTDMNV-VVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKF 2138
            .|.||||:|.||||:.||..||:.|....| |.|.||..:::     .:.....||       ||
 Frog   785 RINGPFLIIVPLSTLSNWVYEFDKWGPSVVKVSYKGSPAARR-----AFVPMLRSG-------KF 837

  Fly  2139 NVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEH----RVLLSGTPLQ 2199
            |||:||:|.|:.|...|....|:..::||.||:||.:|||.:   .||..:    ||||:|||||
 Frog   838 NVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQ---VLNTHYVAPRRVLLTGTPLQ 899

  Fly  2200 NNISELFSLLNFLEPSQFSSQEEFMSEFGS----------LRTEEE---VNKLQALLKPMMLRRL 2251
            |.:.||::|||||.|:.|.|...|...|.:          |..||.   :.:|..:|:|.:||||
 Frog   900 NKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRL 964

  Fly  2252 KDDVEKSLAPKEETIIEVELTNIQKKYYR-----GIL-----EQNFSFLKKGTTSANIPNLMNTM 2306
            |.:||..|..|.|.:|:.:::::|:..||     |:|     |::    |||  ......||||:
 Frog   965 KKEVEAQLPEKVEYVIKCDMSSLQRVLYRHMQAKGVLLTDGSEKD----KKG--KGGTKTLMNTI 1023

  Fly  2307 MELRKCCIHPYLLNGAEEQIQYDFKSQH---------GEDPESYYKNLILSAGKMVLIDKLLPKL 2362
            |:|||.|.|||:....||..     |:|         |.|       |..::||..|:|::||||
 Frog  1024 MQLRKICNHPYMFQHIEESF-----SEHLGFSGGIVQGAD-------LYRASGKFELLDRILPKL 1076

  Fly  2363 KANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTK 2427
            :|..|:||:|.||...:.|:|||..||.:.:.|:||..:...|...:..:::..|:.|:|||.|:
 Frog  1077 RATQHKVLLFCQMTTLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNESSSEYFIFLLSTR 1141

  Fly  2428 AGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKL 2492
            |||||:||.:||||||:||||||..|||||.|.|||||:..|::.||...|:.|.::...|..||
 Frog  1142 AGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKL 1206

  Fly  2493 GLDKAVLQS-MNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAG----------DKFCEED 2546
            .:|:.|:|: |..|.|.....|...:..:|...:......|.||:...          |.|...|
 Frog  1207 NVDQKVIQAGMFDQKSSSHERKVFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMD 1271

  Fly  2547 IDS-----------------------ILKRRTQV--ITMESEKGSTFSKASFAASGNRSDITIDD 2586
            :|.                       |:|...:|  :|.|.|:...|.:    .|.||.::...|
 Frog  1272 LDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGR----GSRNRKEVDYSD 1332

  Fly  2587 PDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHED---VMELNSEESSNENSDEEG 2648
            .....:|.|       |.|....|::.....:::|..||....|   ||...|  :.....|:||
 Frog  1333 SLTEKQWLK-------AIEEGTLEEIEEEVRQKKTTRKRKRDIDPCIVMPTTS--TRGRERDDEG 1388

  Fly  2649 GIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAK-SECF---KVEKGLLSF 2709
                 .:::|..|..|.:...|...:.::...:....::....||..: ||.|   ...|.|
 Frog  1389 -----KKQKKRGRPPAEKLSPNPPKLTKKMKKIVDAVIKYKDSGNGRQLSEVFIQLPSRKEL--- 1445

  Fly  2710 GWGRWSELL-------ELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDG 2767
              ..:.||:       ::.:..|..:...:.|..:.::|.|       :..:||..:.....||.
 Frog  1446 --PEYYELIRKPVDFRKIKERIRNHKYRSLNDLEKDVMLLC-------QNAQTFNLEGSLIYEDS 1501

  Fly  2768 EV---------QKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNS 2812
            .|         |||.::.          .:.|:.::|...|.  ..||.|.|.|
 Frog  1502 IVLQSVFTSVRQKIEKEE----------ESEGEESEEEEDVE--EEGSESESRS 1543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941	45/222 (20%)
		PRK12678	1319..>1500	CDD:237171	29/183 (16%)
		PTZ00121	<1419..1923	CDD:173412	89/555 (16%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	13/66 (20%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	14/68 (21%)
		PLN03142	2029..>2606	CDD:215601	233/650 (36%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
smarca4	NP_001362194.1	Atrophin-1	<60..>459	CDD:460830	101/619 (16%)
		QLQ	164..198	CDD:462622	6/42 (14%)
		Smc	<349..>591	CDD:440809	50/304 (16%)
		HSA	445..517	CDD:214727	11/75 (15%)
		BRK	596..639	CDD:462196	10/53 (19%)
		DEXHc_SMARCA4	715..965	CDD:350820	107/308 (35%)
		PLN03142	734..>1216	CDD:215601	209/545 (38%)
		SnAC	1273..1340	CDD:464219	12/70 (17%)
		Bromo_SNF2L2	1408..1515	CDD:99947	19/118 (16%)