DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kis and dom

DIOPT Version :9

Sequence 1:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster
Sequence 2:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster


Alignment Length:3314 Identity:654/3314 - (19%)
Similarity:1032/3314 - (31%) Gaps:1276/3314 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   898 MDNTNSHGGNSESAQNAGVDVGLFDNNSMSSNSAAVAAVASNAASAAAALLDSNSQSSNAEFEKN 962
            |:..||.||..|....|...|.  |..:..|...:||...|.:.:..||      .|..|.....
  Fly     1 MNEGNSAGGGHEGLSPAPPAVP--DRVTPHSTEISVAPANSTSTTVRAA------GSVGAALPAT 57

  Fly   963 QSEGEGLGVVEGVIANETDLPQDENSVSKTQDITLSTELPTIQDDL--QEKPTAEMEQTQLGQSL 1025
            :........|:|:          .:|.||.|....|.:||.....|  |::.|||........:.
  Fly    58 RHHQHIATQVKGI----------ASSSSKQQKQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAH 112

  Fly  1026 GDLSKSLLEEPKTVEES-------------GEDKSQSAPGVAPPADPIIPVTQPPQQQMPPIGMP 1077
            .::|.|    ..|:|.|             .||::.:|..|.|.....|                
  Fly   113 SNVSVS----SSTIEASVLPPQAKRQRLDDNEDRTSAASIVGPAESSNI---------------- 157

  Fly  1078 MHPIAPGYEAQAQGQGHMPPMMPPYGGAPGMYPPYPMLHQQEIAALQQQIQELYCMPPGHELQHQ 1142
            :..:.|...|.:...|.:....                 .|::.||:::|           ||.:
  Fly   158 VSSLLPASVASSSEVGGLSSTA-----------------LQDLNALKKRI-----------LQQK 194

  Fly  1143 DKLMRMQERLNLLTQHEVND------QCAGG-------------PQCLLFQNV----------PP 1178
            .:::|     ||..:|..|.      |..|.             ||.:.:.|.          .|
  Fly   195 LQILR-----NLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYSNANRIDQLIHEDKP 254

  Fly  1179 MYGPPGNPLLNQ----QMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVGQQQDLMDISGNV 1239
            ..........||    |..:|.:.|..:|.|.|.:...|                     :.||:
  Fly   255 STSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAP---------------------LDGNI 298

  Fly  1240 AMGA--ANAVSSIPTT--QLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLSQDVHSANELDTSTDG 1300
            :...  .|..|.:|:.  ....|....|:....|:|.|.               :.:...|||..
  Fly   299 SNSTVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGT---------------ATSGAATSTSA 348

  Fly  1301 SGKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDPNSTETPAAVKK---------RAGASKRRK 1356
            :..:..........:...|....||.|         .||:.||||.:         |....:...
  Fly   349 TSAEASGNVLAVEAEIKIPAVGATPVA---------ISTKLPAAVVQLTQQGHIPGRPLGGRHGM 404

  Fly  1357 QYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIPRGSNEDE 1421
            .:|:..|.....|:   .:.|||| .|:......|::|.|.:             :.|:|.|   
  Fly   405 VFGQIPAPPAAVGN---PSVPLVP-GGTPLLPCNTSAGSTAL-------------RRPQGQN--- 449

  Fly  1422 KEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAKALKKRRN 1486
             .|.:|     |...|.|..:.||        |.....|..:..|||.....|:.::.:|     
  Fly   450 -NASSG-----SAAASGGGGSLTP--------TPLYTGNGPAALGGSGGLTPGTPTSGSL----- 495

  Fly  1487 RGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSD-DENSLLVAS 1550
               :.|...|...|          |:|.    .:..|...:::.|   ||.|.|: ....|....
  Fly   496 ---LSPALGGGSGT----------PNSA----AQEFSFKAKQEVY---VMQRISELQREGLWTER 540

  Fly  1551 PVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEK 1615
            .:.|.::||...::.:     ...|.......|.|||...:|:           |:...:.:.:|
  Fly   541 RLPKLQEPSRPKAHWD-----YLLEEMVWLAADFAQERKWKKN-----------AAKKCAKMVQK 589

  Fly  1616 ERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKREL-----ILDKPKEKAPEPK-Q 1674
            ..|   |.|.||..:           |.:..:||........||:     .::|..|...:.| :
  Fly   590 YFQ---DKATAAQRA-----------EKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIE 640

  Fly  1675 DEEKSELDEATTDKPEGDEKFK---TEGESKK--DLTDSEETKLESSAMEVDSKEESEPDDSKKS 1734
            ::.|..||:..:...:..|||.   .||.:|.  |......::|.|...|.|  ::..|:...:.
  Fly   641 EKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESD--DDFRPESGSED 703

  Fly  1735 DED---NKDKDKMEVDDEVGKSDKESKPE-------------EQSETVKTEENSKAIEEDKSSTV 1783
            ||:   ..::|..:|.:||....|||:.:             |..:.:..||.|.||:.:     
  Fly   704 DEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTE----- 763

  Fly  1784 LTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKER 1848
             |.|.:.:.|     .|..|.::||::.:||.|                                
  Fly   764 -TPDDSDDSE-----FEAKEASDDDENTISKQE-------------------------------- 790

  Fly  1849 VKEGEESV--KKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAA 1911
              |.|:.:  |||.|| .|||.:       :.||:...||          ::|:......|::|.
  Fly   791 --EAEQEIDHKKEIDE-LEADND-------LSVEQLLAKY----------KSEQPPSPKRRKLAP 835

  Fly  1912 KIRRF-QQKQSQQLNIFENIEDEPF--NQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYE 1973
            :.... ....|..::..|..||...  .:|.:.|....||....::..|         .|||..:
  Fly   836 RDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDG---------LKSLMAD 891

  Fly  1974 -DCTWEL------------EEDVDND--KIEQYLRFNKIPQRSEWKSKK--RPHPELWKKLEKTP 2021
             |.|...            ::|:.||  .:.:.|:    |:.:...|..  .|.|.|.|      
  Fly   892 ADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQ----PKGNTLSSTNVVTPVPFLLK------ 946

  Fly  2022 VYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFV-HSVYEYGIRGPFLVIAP 2085
                 :|||.||..||:||........|.|||||||||||||::..: |.....|..||.|::.|
  Fly   947 -----HSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVP 1006

  Fly  2086 LSTIPNWQREFEGW-TDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLK-----EPIKFNVLITT 2144
            .|.:.||:.||:.| ....::.|:||                :..:.||     :|..|:|.||:
  Fly  1007 SSVMLNWEMEFKKWCPGFKILTYYGS----------------QKERKLKRVGWTKPNAFHVCITS 1055

  Fly  2145 FEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLL 2209
            ::::|.|....:...|:..::|||..:||...:..:.|...:.|.|:||:||||||::.||:||:
  Fly  1056 YKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLM 1120

  Fly  2210 NFLEPSQFSSQEEFMSEFGSLRT----------EEEVNKLQALLKPMMLRRLKDDVEKSLAPKEE 2264
            :||.|..|||..||...|.:..|          |..:.:|..:::|.:|||||.:|||.:..|.|
  Fly  1121 HFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYE 1185

  Fly  2265 TIIEVELTNIQKKYYRGILEQNFSFLKKGTT-----SANIPNLMNTMMELRKCCIHPYL------ 2318
            .:|...|:|.|:..|.       .|:.:..|     :.|:.:::|.:|:|||.|.||.:      
  Fly  1186 HVITCRLSNRQRYLYE-------DFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPT 1243

  Fly  2319 ----------------------------------------------------------------- 2318
                                                                             
  Fly  1244 ISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIED 1308

  Fly  2319 ----------------------------------------------------------------- 2318
                                                                             
  Fly  1309 IDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLK 1373

  Fly  2319 ---------------------------------------------LNGAEEQI------------ 2326
                                                         |.||..||            
  Fly  1374 RVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTM 1438

  Fly  2327 ----------------------------------------------------------------- 2326
                                                                             
  Fly  1439 QDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVK 1503

  Fly  2327 ---------------------QYDFKSQ------------------------------HGEDPES 2340
                                 :..:|.|                              :|||...
  Fly  1504 STVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCRE 1568

  Fly  2341 ----------------------------------------------------------------- 2340
                                                                             
  Fly  1569 AIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSV 1633

  Fly  2341 -------YYKNL----------------------------ILS---------------AGKMVLI 2355
                   |.:||                            |:|               .||:..:
  Fly  1634 CAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTM 1698

  Fly  2356 DKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDR- 2419
            |:||.:||.||||||||:||.:.||:||.:|.|..:.:.|:||..|...||..::|::  |..| 
  Fly  1699 DRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFN--GDKRI 1761

  Fly  2420 FVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREM 2484
            |.|:|.|::||:|||||.|||||.|||||||..|.|||.|||||||.:.|.||||:...|.|..:
  Fly  1762 FCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNI 1826

  Fly  2485 FDKASMKLGLDKAVLQSMN--TQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDI 2547
            ..||:.|..|....::..|  |...|....|.|...|..:           .|:::.:|  .|:.
  Fly  1827 LKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSE-----------QDESSQEK--SENK 1878

  Fly  2548 DSILKRRTQVIT----MESEKGS--TFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACER 2606
            |.|:...|...|    :|:||.|  .|..|..||.        |:.|.......|.::..|..|.
  Fly  1879 DRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAE--------DEQDVQATKTAKAEVAADLAEF 1935

  Fly  2607 DETEDLVLSEP---------------------RRRTQIKRYGHEDVMELNSEESSNENSDEEGGI 2650
            ||...:...:|                     ::.:.|:||....|             :|.|..
  Fly  1936 DENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFV-------------EETGAA 1987

  Fly  2651 GLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWS 2715
            ....:.|..:.:...:|:   |:   |.:.|||:..||         |..|.|           :
  Fly  1988 WTAEQLRAAEAELEAQKR---EW---EANRLAAMHKEE---------ELLKQE-----------T 2026

  Fly  2716 ELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTF-IWDLITPTEDGEVQKISRDH--S 2777
            |..|:..:.|       :|.:.       ||:.....::.. :|...||.:|.: ..|..|:  |
  Fly  2027 EAEEMLTYSR-------KDSSN-------QVWISRNTMEQMPMWCPPTPPQDND-NDIYIDYSLS 2076

  Fly  2778 GLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPA-----HKSSALDGSDKDSGGINAS 2837
            .::.|.|.             ..|..|            |.     ||.|..|      .|.:.|
  Fly  2077 FMYELEPI-------------AETDLP------------PVYVRKEHKRSRTD------AGYDGS 2110

  Fly  2838 AVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIK 2902
                     ..||...:::.|        ...:.|.......|.|:|.....|.     |....|
  Fly  2111 ---------RRPNKMRREDNY--------VPPRSLFDRPTPQLARLRRELKSQR-----FRGSFK 2153

  Fly  2903 DNTPI----SELPIRPPPTPDQVPSSWWNPIC------------------CDKSL---------- 2935
            .|.||    .:||.:|...|:.: :.|    |                  |...|          
  Fly  2154 PNMPIPGLKPQLPTKPLTEPEAM-AEW----CVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWD 2213

  Fly  2936 LVGTYKHGC-EMYRQMRADPNLC---FVTHVGAGAAGD-------------------------DL 2971
            ||....:.| :.||..|.    |   :.||:.....|.                         .|
  Fly  2214 LVSEMVNFCSKTYRSARQ----CRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYL 2274

  Fly  2972 AVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLT------------------GGDNKDSL 3018
            ..|.|.:::::|:.........|...|...|.:...|..                  |..|.|..
  Fly  2275 RTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILNYDQP 2339

  Fly  3019 LDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSE--------VLPGKGSDLDV----- 3070
            :.|:..::...:.......|...::.......|.:...:|:        .||.:.....|     
  Fly  2340 VSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQVVQQVQ 2404

  Fly  3071 -----SVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSS---PEAAGKAQGTGVQTG 3127
                 ...||.......:|...|:.:......|....|...|..:::   |.|.|:.|       
  Fly  2405 QQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQ------- 2462

  Fly  3128 DAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNISTTTTTTT- 3191
               :|.|:.....|     .|.|...|:...:....:....|...:|.|......|..|:::.| 
  Fly  2463 ---QLQIQHLTSSN-----VSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTA 2519

  Fly  3192 ---------------------ITNTTTTTNNPS---------SKAANSNNTTDHANSNSHLG-LD 3225
                                 :..||.....||         ::..:.::.|...||:..|| :.
  Fly  2520 GQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQIGSGAQIVSISSQTLPVNSSPQLGSIV 2584

  Fly  3226 EEES----VAGSYPPTVAAVEDATTMWPSMQ-------DLNT---RLRRVITAYQRNYKKEELKL 3276
            :.:|    |:.|..|||..|...|...|..|       .|||   |.:|:::....|      .|
  Fly  2585 QTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTAAGN------TL 2643

  Fly  3277 QQK--AKLQALVS-------STPP--------LSVPTTPTLQSMQM---------QLQSG----- 3310
            ||:  |..|::||       ::|.        .:|||:|..|:.|:         .||.|     
  Fly  2644 QQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSALQQGGKTTV 2708

  Fly  3311 ----SGSGGSGIGSSAQHDASGRSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQVGMGG---- 3367
                ..|||:.|....|     |||:.|..:..|..|.:|.|..::|       ..|..||    
  Fly  2709 IPVTQQSGGAHIQLYRQ-----RSLKVLQTTTQAVPSGSAGATGATA-------NLVQAGGTIIQ 2761

  Fly  3368 AGVMPAMPTAADISLMLSILNTTDVNQLANLDINKLAMYLVSMNNKMERQGKMELAAKERESQR 3431
            |..|....|:..:::. .:..|:...|..|:      :..|.|:.:...|...::||.:::.||
  Fly  2762 ASNMATHVTSQKVAVS-GMPGTSTTVQAGNV------VSSVQMHGQARTQFIKQMAAGKQQLQR 2818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kisNP_001137761.1 BASP1 1554..1786 CDD:283191 54/258 (21%)
HepA 1676..2527 CDD:223627 286/1342 (21%)
SDA1 <1693..>1854 CDD:283052 38/181 (21%)
CHROMO <1879..1919 CDD:237991 7/40 (18%)
Chromo 1941..1996 CDD:278797 13/69 (19%)
DEXDc 2048..2197 CDD:238005 50/155 (32%)
Helicase_C 2350..2464 CDD:278689 63/114 (55%)
RR_TM4-6 3728..>3877 CDD:283990
BRK 4569..4613 CDD:197800
domNP_001286676.1 HSA 543..614 CDD:214727 19/100 (19%)
ASF1_hist_chap <674..831 CDD:304562 46/221 (21%)
FAM176 <824..>868 CDD:291517 7/43 (16%)
SNF2_N 952..1238 CDD:278600 104/308 (34%)
DEXDc 969..1108 CDD:238005 50/154 (32%)
Helicase_C 1692..1806 CDD:278689 63/115 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467113
Domainoid 1 1.000 47 1.000 Domainoid score I705
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.930

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